Feeding DigestaWell Buffer to Horses Alters the Effects of Starch Intake on Blood pH, Lipopolysaccharide, and Interleukin-1β

Suagee-Bedore, J.K.; Wagner, Anne; Girard, I.D.

doi:10.1016/j.jevs.2017.11.006

Cited by 4 publications

(3 citation statements)

References 63 publications

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“…Regarding our first finding, we observed that overweight horses responded to the barley consumption differently from lean horses. We have previously reported an effect of NSC consumption to induce an immediate post-prandial elevation in IL-1β concentrations within 1 h of feeding on the first day of feeding [ 7 , 9 ]. In the current study’s first trial, which used horses of middle age, lean horses did not have an IL-1β response on day 1.…”

Section: Discussionmentioning

confidence: 99%

“…Our previous work has demonstrated this finding in Thoroughbred mares consuming 1.14 g NSC/kg bodyweight and in mixed breed geldings consuming 1.2 g NSC/kg bodyweight [ 7 , 8 ]. Furthermore, we have also previously shown that blood concentrations of LPS are increased at 2 h post meal consumption in horses [ 9 ], suggesting inflammasome priming could be occurring in the post-prandial state.…”

Section: Introductionmentioning

confidence: 99%

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Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses

Suagee-Bedore

Shost

Miller

et al. 2021

Animals

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Older horses and those prone to obesity may be at a higher risk for inflammation than younger and leaner counterparts. Previous research indicated a postprandial elevation in plasma concentrations of interleukin-1β (IL-1β), a pro-inflammatory cytokine, after consuming 1.2 g of non-structural carbohydrates/kilogram of body weight. However, these studies utilized horses of mixed age and body condition. The current study evaluated post-prandial IL-1β concentrations in horses specifically comparing lean to over-conditioned and middle aged to older. Our results suggest that at least two weeks of daily consumption of a high non-structural carbohydrate diet is required to induce a post-prandial increase in IL-1β concentrations in younger and leaner horses. In opposition to this, older and over-conditioned horses experience plasma increased on the first day of feeding and thereafter. Feeding management practices of older and over-conditioned individuals should emphasize lower non-structural carbohydrate intakes and further research should elucidate mechanisms of IL-1β activation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses

Suagee-Bedore

Shost

Miller

et al. 2021

Animals

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“…Because the drop of pH is the direct consequence of Dlactate poisoning, application of sodium bicarbonate or any other drug for acidosis-resolving purposes is recommended as first-choice therapy [103][104][105][106]. Alteration of microbiota composition like suppression of D-lactic acid-producing Lactobacillus strains by competitive probiotics is a prophylactic way leading to prevention of D-lactate exposition [50].…”

Section: Diagnosis and Therapymentioning

confidence: 99%

D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

Pohanka

2020

BioMed Research International

123

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Two enantiomers of lactic acid exist. While L-lactic acid is a common compound of human metabolism, D-lactic acid is produced by some strains of microorganism or by some less relevant metabolic pathways. While L-lactic acid is an endogenous compound, D-lactic acid is a harmful enantiomer. Exposure to D-lactic acid can happen by various ways including contaminated food and beverages and by microbiota during some pathological states like short bowel syndrome. The exposure to D-lactic acid cannot be diagnosed because the common analytical methods are not suitable for distinguishing between the two enantiomers. In this review, pathways for D-lactic acid, pathological processes, and diagnostical and analytical methods are introduced followed by figures and tables. The current literature is summarized and discussed.

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Feeding Grass Hay Before Concentrate Mitigates the Effect of Grain-Based Concentrates on Postprandial Plasma Interleukin-1β

Suagee-Bedore

Linden

Bennett-Wimbush

et al. 2020

Journal of Equine Veterinary Science

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Feeding DigestaWell Buffer to Horses Alters the Effects of Starch Intake on Blood pH, Lipopolysaccharide, and Interleukin-1β

Cited by 4 publications

References 63 publications

Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses

Age and Body Condition Influence the Post-Prandial Interleukin-1β Response to a High-Starch Meal in Horses

D-Lactic Acid as a Metabolite: Toxicology, Diagnosis, and Detection

Feeding Grass Hay Before Concentrate Mitigates the Effect of Grain-Based Concentrates on Postprandial Plasma Interleukin-1β

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