Feeding Produced in the Satiated Rat by Elevating the Concentration of Calcium in the Brain

Myers, R.D.; Bender, S.; Krstić, M.K.; Brophy, P. D.

doi:10.1126/science.176.4039.1124

Cited by 42 publications

(4 citation statements)

References 26 publications

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“…The effect of Ca + + on food intake in broilers was consistent with previous reports in cats, rats, and sheep (Myers and Veale, 1971a;Myers et al, 1972;Myers and Bender, 1973;Seoane and Baile, 1973). Furthermore, the effect seemed to be a specific Ca + + effect and not a Cl~ or osmotic effect, as an equivalent amount of Cl~ injected as the salt of NaCl or an isosmotic solution of NaCl in Experiment 2 had no effect on food or water intake (Table 1).…”

Section: Resultssupporting

confidence: 90%

“…First, as stated previously, ICV or intrahypothalamic injections of Ca + + stimulated food intake in the rat (Myers and Veale, 1971a;Myers et al, 1972;Myers and Bender, 1973), sheep (Seoane and Baile, 1973), and pig (Baldwin etal., 1970). Second, calcitonin, which is involved in regulating Ca + + metabolism and is found both peripherally (Munson, 1976) and centrally (Flynn etal., 1981), has been shown to decrease food intake when injected ICV in the rat (Freed et al, 1979;Twery et al, 1982).…”

Section: Discussionmentioning

confidence: 96%

“…The ionostatic theory proposes that calcium, act-ing at the level of the hypothalamus, controls the set-point for weight or hunger (Myers et al, 1972). Myers and Veale (1971a) reported that hypothalamic infusions of excess calcium or sodium caused a dose-dependent increase in food intake in cats.…”

Section: Introductionmentioning

confidence: 99%

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Ionostatic Control of Food Intake in the Domestic Fowl

Denbow

Krey

1987

Poultry Science

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It has been suggested that there is ionostatic control of food intake in which calcium, acting in the hypothalamus, alters food intake. This study was conducted to determine the effects of intracerebroventricular (ICV) injections of calcium on food and water intake in both broiler and Leghorn cockerels. The ICV injection of 50, 100, or 150 mM CaCl2 had no significant affect on food or water intake in Leghorn cockerels. In broilers, the ICV injection of 50 mM CaCl2 significantly increased food intake. This effect appeared to be due to Ca++ as equivalent amounts of Cl- given as NaCl had no effect on food intake nor did isosmotic solutions of NaCl. The effect of Ca++ on water intake in broilers is equivocal as it increased water intake in one experiment while decreasing it in another. Whereas these results support the hypothesis of a role for calcium in food intake regulation in broilers, they do not support the existence of a specific ionostatic control mechanism.

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Section: Resultssupporting

confidence: 90%

Section: Discussionmentioning

confidence: 96%

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Ionostatic Control of Food Intake in the Domestic Fowl

Denbow

Krey

1987

Poultry Science

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“…Elevation of ICV calcium stimulates feeding in rats [26], and, conversely, the uptake of 45Ca is inhib ited by sCT in hypothalamic expiants in vitro [18,19]. The detailed mechanism of the inhi bition of gastric secretion by CT in the brain remains to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Intraventricular Salmon Calcitonin and Suppression of Gastric Secretion

et al. 1985

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Intracerebroventricularly (ICV) administered [¹²⁵I] salmon calcitonin (sCT) was rapidly transported to the blood, but the permeability of the blood-brain barrier to sCT was low. ICV injected intact [¹²⁵I]sCT was predominantly deposited in the periventricular mesencephalon and in the kidneys, and intravenously (IV) injected [¹²⁵I]sCT in the kidneys, respectively. After both ICV and IV administration [¹²⁵I]sCT was not retained by the stomach in large amounts. ICV and subcutaneously (SC) injected sCT caused suppression of gastric secretion volume, and of acid and pepsin outputs; the potency ratios between half maximal inhibitory amounts of sCT administered SC and ICV were 161, 252 and 13, respectively. On the other hand, perfusion of isolated whole mouse stomachs with sCT did not affect basal or stimulated acid and pepsin secretion. These findings indicate that sCT inhibits gastric acid secretion via receptors localized in the hypothalamus and in adjacent areas of the brain.

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The Psychopharmacology of Feeding

Hoebel

1977

Drugs, Neurotransmitters, and Behavior

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Feeding Produced in the Satiated Rat by Elevating the Concentration of Calcium in the Brain

Cited by 42 publications

References 26 publications

Ionostatic Control of Food Intake in the Domestic Fowl

Ionostatic Control of Food Intake in the Domestic Fowl

Distribution of Intraventricular Salmon Calcitonin and Suppression of Gastric Secretion

The Psychopharmacology of Feeding

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