Feeding with Both β-Carotene and Supplemental α-Tocopherol Enhances Type 1 Helper T Cell Activity among Splenocytes Isolated from DO11.10 Mice

Koizumi, Tomoko; Bando, Noriko; Terao, Junji; Yamanishi, Rintaro

doi:10.1271/bbb.60371

Cited by 13 publications

(8 citation statements)

References 16 publications

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“…This finding is consistent with our previous study, according to which -carotene in the up-regulation of IFN-secretion could not be replaced by retinol. 12) The contribution of vitamin A activity derived from -carotene cannot be denied, but the contribution of vitamin A was not sufficient in the present study to produce the effects observed.…”

Section: Discussioncontrasting

confidence: 62%

Ingested β-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes

Takeda¹,

Bando²,

Yamanishi³

2008

Bioscience, Biotechnology, and Biochemistry

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Section: Discussioncontrasting

confidence: 62%

Ingested β-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes

Takeda¹,

Bando²,

Yamanishi³

2008

Bioscience, Biotechnology, and Biochemistry

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“…In studies evaluating β-carotene, mice have been fed <10 mg β-carotene/kg chow (114), up to 12,000 mg β-carotene/kg chow (115), with 500 mg β-carotene/kg chow providing an intermediate supplement level (116, 117). The Diet B formulation used in this study included 224 mg β-carotene/kg chow (see Table 1).…”

Section: Discussionmentioning

confidence: 99%

Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss

Prell

Gagnon

Bennett

et al. 2011

Translational Research

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Oxidative stress has been broadly implicated as a cause of cell death and neural degeneration in multiple disease conditions; however, the evidence for successful intervention with dietary antioxidant manipulations has been mixed. In this study, we investigated the potential for protection of cells in the inner ear using a dietary supplement with multiple antioxidant components, selected for their potential interactive effectiveness. Protection against permanent threshold shift (PTS) was observed in CBA/J mice maintained on a diet supplemented with a combination of β-carotene, vitamins C and E, and magnesium when compared to PTS in control mice maintained on a nutritionally complete control diet. Although hair cell survival was not enhanced, noise-induced loss of Type II fibrocytes in the lateral wall was significantly reduced (p<0.05), and there was a trend towards less noise-induced loss in strial cell density in animals maintained on the supplemented diet. Taken together, our data suggest that pre-noise oral treatment with the high-nutrient diet can protect cells in the inner ear and reduce PTS in mice. Demonstration of functional and morphological preservation of cells in the inner ear with oral administration of this antioxidant supplemented diet supports the possibility of translation to human patients, and suggests an opportunity to evaluate antioxidant protection in mouse models of oxidative stress-related disease and pathology.

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“…Astaxanthine [9 ] and cryptoxanthine [10] have gained special interest. Some papers have reported the synergy resulting from carotene-tocopherol interactions [11] and also that observed for a mixture of various carotenes [12]. Furthermore, the importance of functional lipids such as eicosapentaenoic [13] and docosahexaenoic [14] acids are highlighted.…”

Section: Basic Science On Nonnutritive Functional Food Componentsmentioning

confidence: 98%

“…The projects (1984)(1985)(1986)(1987)(1988)(1989)(1990)(1991) were followed by another MESC project 'Analysis and molecular design of functional foods' (1992)(1993)(1994)(1995), and then by an academia-industry collaborative project 'Analysis and systematization (database construction) of nonnutritive functional components in Table 1 Eleven categories of health claims in food for specified health use products and their approved functional food components a Category 1: Modulation of gastrointestinal conditions 1 Oligosaccharides: lactosucrose (27); galacto-oligosaccharides (11); coffee bean manno-oligosaccharides including mannobiose (11); fructo-oligosaccharides (9); soybean oligosaccharides (6); xylo-oligosaccharides (4); isomalto-oligosaccharides (4); lactulose (1); raffinose (1) 2 Lactic acid bacteria: Lactobacillus casei Shirota (27);…”

Section: Basic Science On Nonnutritive Functional Food Componentsmentioning

confidence: 99%

Functional food science and food for specified health use policy in Japan: state of the art

Arai

Yasuoka²,

Abe³

2008

Current Opinion in Lipidology

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Functional foods, defined as those that have the potential to reduce the risk of lifestyle-related diseases and associated abnormal modalities, have garnered global interest since the 1980s when the systematic research had humble beginnings as a national project in Japan. In 1991, the project led to the launch of the national food for specified health use policy; 703 food for specified health use products with 11 categories of health claims have been approved up to the present (31 August 2007). The development of this policy has been supported basically by nutritional epidemiology, food chemistry and biochemistry, physiology and clinical medicine, and even the genomics on food and nutrition. This review also highlights the current academia-industry collaboration in Japan.

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Feeding with Both β-Carotene and Supplemental α-Tocopherol Enhances Type 1 Helper T Cell Activity among Splenocytes Isolated from DO11.10 Mice

Cited by 13 publications

References 16 publications

Ingested β-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes

Ingested β-Carotene Enhances Glutathione Level and up-Regulates the Activity of Cysteine Cathepsin in Murine Splenocytes

Nutrient-enhanced diet reduces noise-induced damage to the inner ear and hearing loss

Functional food science and food for specified health use policy in Japan: state of the art

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