Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat

Takashima, Tadayoshi; Sakata, Yasuhisa; Iwakiri, Ryuichi; Shiraishi, Ryosuke; Oda, Yoshimasa; Inoue, Norie; Nakayama, Atsushi; Toda, Shuji; Fujimoto, Kazuma

doi:10.1016/j.jnutbio.2013.10.005

Cited by 48 publications

(56 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These observations indicate that olive oil may have some anti-inflammatory effects alone. In agreement with our finding, anti-inflammatory effects of olive oil have been demonstrated in other studies (44,45). Olive oil has been used as a vitamin D vehicle in our study.…”

Section: Discussionsupporting

confidence: 94%

The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis

et al. 2018

View full text Add to dashboard Cite

KEYWORDS ABSTRACTExperimental Autoimmune Encephalomyelitis Vitamin D IL-12 TGF-β Background & objective:The immunoregulatory effects of transforming growth factor (TGF)-βand interleukin-12 (IL-12) and immunomodulatory actions of vitamin D (VD) were reported in several studies. This study aims to evaluate VD effects on IL-12 and TGF-β expression in experimental autoimmune encephalomyelitis (EAE).Methods: EAE was induced in three groups of C57BL/6 mice by immunization with MOG and administered intra-peritoneally 200 ngVD, PBS or olive oil (OO) from day +3 to +30. One group was also considered as healthy control group. At day 31, cytokines expression in the spinal cord and their serum levels were determined using real time-PCR and ELISA, respectively.Results: IL-12 gene expression and its serum levels in PBS-injected-or OOadministrated EAE groups were significantly higher than healthy group. IL-12 gene expression in EAE group treated with VD was significantly decreased compared to PBS-injected-or OO-administrated EAE groups (P<0.001 and P<0.02, respectively). Serum IL-12 levels were significantly reduced in VD-treated EAE mice compared to PBS-injected-or OO-administrated EAE groups (P<0.004 and P<0.05, respectively). No significant difference was observed between PBS-injected-EAE, OOadministrated EAE and healthy groups regarding the expression of TGF-β. In EAE mice treated with VD, TGF-β expression was significantly higher than healthy group and PBS-injected EAE mice (P<0.01 and P<0.04, respectively). VD-treated EAE group had also higher serum TGF-β levels than PBS-injected-, OO-administrated and healthy groups (P<0.05).Conclusion: VD modulates the expression of IL-12 and TGF-β in spinal cord and serum of EAE mice. Article Info

show abstract

Section: Discussionsupporting

confidence: 94%

The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis

et al. 2018

View full text Add to dashboard Cite

show abstract

“…They also demonstrated that dietary EVOO and EVOO enriched with hydroxytyrosol reduced the severity of chronic colonic damage induced by an acute exposure to DSS [12]. Similarly, Takashima et al[30] reported that a 5% olive oil-rich diet attenuated inflammation in DSS-induced colitis in rats. In our study, EVOO contained 718 mg/kg of oil of total phenols, resulting in a daily dose of 4.3 mg/kg/bw.…”

Section: Discussionmentioning

confidence: 99%

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

Bigagli¹,

Toti²,

Lodovici³

et al. 2018

Lifestyle Genomics

View full text Add to dashboard Cite

Background: Human studies have demonstrated that olive oil phenolic compounds reduce inflammatory markers associated with chronic diseases. Objectives: To explore the anti-inflammatory effects of extra-virgin olive oil polyphenols in an experimental model of inflammatory bowel disease (IBD). Methods: HLA-B27 transgenic rats were fed an AIN-76 diet containing 10% corn oil (CO) or extra-virgin olive oil with high (EVOO) or low phenolic content (ROO) for 3 months. Wild-type rats (WT) were fed the CO diet. Results: CO-fed HLA-B27 animals developed intestinal inflammation characterized by diarrhea, increased myeloperoxidase activity, and mucosal injury. None of these parameters were influenced by EVOO. Gene expression profiling indicated that proinflammatory pathways were upregulated in the colon mucosa of CO-fed HLA-B27 rats compared to WT, and this was further confirmed by RT-PCR for the iNOS, TNFα, and IL1β genes. EVOO significantly reduced TNFα gene expression in the colon mucosa and decreased total cholesterol blood levels compared to CO HLA-B27 rats (89.43 ± 3.66 vs. 111.5 ± 8.10 mg/dL, p < 0.05). This latter effect with EVOO was associated with reduced HMGCR and increased PPAR-α hepatic gene expression, compared to ROO. Conclusion: These data indicate that olive oil polyphenols do not control colon inflammation in HLA-B27 transgenic rats but exert a positive effect on blood lipids by reducing total cholesterol levels. This preliminary result suggests the need to explore the efficacy of EVOO rich in polyphenols as a complementary strategy for managing hypercholesterolemia and to potentially limit statin-associated myotoxicity.

show abstract

“…A number of other polyphenols have been solely administered in rodent models of colitis. These include apocynin (acetovanillone), 58 canolol (4-vinyl-2,6-dimethoxyphenol), 103 oleuropein, a phenolic secoiridoid from olive, 60,104 chrysin, a flavone, 105,106 silymarin, 107 icariin ( prenylated kaempferol diglucoside), 108 esculetin and 4-methylesculetin (coumarin derivatives), 109 hydroxytyrosol and tyrosol, 110,111 and α-man-gostin (xanthone). 112 Notably, C57BL/6 mice consuming 112 mg α-mangostin per kg bw with DSS-induced colitis had worsened symptoms and greater colonic injury.…”

Section: Other Purified Phenolicsmentioning

confidence: 99%

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

2015

View full text Add to dashboard Cite

Crohn's disease and ulcerative colitis presently have no cure and are treated with anti-inflammatory drugs or monoclonal antibodies targeting pro-inflammatory cytokines. A variety of rodent models have been used to model chronic and acute colitis. Dietary polyphenols in foods and botanicals are of considerable interest for prevention and treatment of colitis. Many dietary polyphenols have been utilized for prevention of colitis in rodent models. Berries, green tea polyphenols, curcumin, and stilbenes have been the most extensively tested polyphenols in rodent models of colitis. The majority of polyphenols tested have inhibited colitis in rodents, but increasing doses of EGCG and green tea, isoflavones, flaxseed, and α-mangostin have exacerbated colitis. Few studies have examined combination of polyphenols or other bioactives for inhibition of colitis. Translating polyphenol doses used in rodent models of colitis to human equivalent doses reveals that supplemental doses are most likely required to inhibit colitis from a single polyphenol treatment. The ability to translate polyphenol treatments in rodent models is likely to be limited by species differences in xenobiotic metabolism and microbiota. Given these limitations, data from polyphenols in rodent models suggests merit for pursuing additional clinical studies for prevention of colitis.

show abstract

Feeding with olive oil attenuates inflammation in dextran sulfate sodium-induced colitis in rat

Cited by 48 publications

References 45 publications

The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis

The Modulatory Effects of Vitamin D on the Expression of IL-12 and TGF-β in the Spinal Cord and Serum of Mice with Experimental Autoimmune Encephalomyelitis

Dietary Extra-Virgin Olive Oil Polyphenols Do Not Attenuate Colon Inflammation in Transgenic HLAB-27 Rats but Exert Hypocholesterolemic Effects through the Modulation of HMGCR and PPAR-α Gene Expression in the Liver

A review of the efficacy of dietary polyphenols in experimental models of inflammatory bowel diseases

Contact Info

Product

Resources

About