Feedlot Acute Interstitial Pneumonia

Woolums, Amelia R.

doi:10.1016/j.cvfa.2015.05.010

Cited by 13 publications

(22 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many of these gene products, especially IL5RA, MS4A2, CPB2, and LIF, are reported in association with Th2-type responses to airway disease [89] [98] [99] [100]. This may be related to the fact that clinical BRD can be driven by extracellular bacterial infection, other extracellular particles, such as LPS or viral structural proteins, and dry, dusty conditions [101], all factors which might stimulate Th2-type responses. While enhancement of genes involved in Th2-type responses and leukocytic recruitment may serve as necessary protective factors against BRD, the converse may also be true, in which Th2-type responses actually moderate protective Th1-mediated inflammatory responses in animals that ultimately resist BRD.…”

Section: Linking Angiotensinogen Metabolism Mast Cell Activation and Physiological Signaling Of Inflammation In Cattle That Resist Brdmentioning

confidence: 99%

Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease

et al. 2020

Self Cite

View full text Add to dashboard Cite

Bovine respiratory disease (BRD) is a multifactorial disease complex and the leading infectious disease in post-weaned beef cattle. Clinical manifestations of BRD are recognized in beef calves within a high-risk setting, commonly associated with weaning, shipping, and novel feeding and housing environments. However, the understanding of complex host immune interactions and genomic mechanisms involved in BRD susceptibility remain elusive. Utilizing high-throughput RNA-sequencing, we contrasted the at-arrival blood transcriptomes of 6 beef cattle that ultimately developed BRD against 5 beef cattle that remained healthy within the same herd, differentiating BRD diagnosis from production metadata and treatment records. We identified 135 differentially expressed genes (DEGs) using the differential gene expression tools edgeR and DESeq2. Thirty-six of the DEGs shared between these two analysis platforms were prioritized for investigation of their relevance to infectious disease resistance using WebGestalt, STRING, and Reactome. Biological processes related to inflammatory response, immunological defense, lipoxin metabolism, and macrophage function were identified. Production of specialized pro-resolvin mediators (SPMs) and endogenous metabolism of angiotensinogen were increased in animals that resisted BRD. Protein-protein interaction modeling of gene products with significantly higher expression in cattle that naturally acquire BRD identified molecular processes involving microbial killing. Accordingly, identification of DEGs in whole blood at arrival revealed a clear distinction between calves that went on to develop BRD and those that resisted BRD. These results provide novel insight into host immune factors that are present at the time of arrival that confer protection from BRD.

show abstract

Section: Linking Angiotensinogen Metabolism Mast Cell Activation and Physiological Signaling Of Inflammation In Cattle That Resist Brdmentioning

confidence: 99%

Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is precipitated by the ruminal degradation of l -tryptophan, a common amino acid in lush forages and feed grains, to 3-methyl indole (3-MI). , It is absorbed, and in high enough concentrations, its metabolites cause damage to pulmonary alveolar cells and AIP can develop. In feedlot cattle being fed a high-grain diet, 3-MI has been targeted as the causative agent of feedlot AIP, but past research has demonstrated inconsistent results. , The amount of l -tryptophan in high-grain diets may not be high enough to create enough 3-MI to be toxic, leading the scientists to consider the cause of feedlot AIP to be multifactorial …”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by Gas Chromatography–Mass Spectrometry

Yao

Maloley

Broeckling

et al. 2020

J. Agric. Food Chem.

View full text Add to dashboard Cite

Ethyl carbamate (EC) is a fermentation byproduct in foods and beverages and classified as a Group 2A probable human carcinogen. Each year, greater than 40 million metric tons of fermentation co-products from the U.S. ethanol industry are fed to food animals. A gas chromatography–mass spectrometry assay was developed to quantify EC extracted from various distillers grains co-products with a limit of detection at 0.7 ng/g (on an as-fed basis). EC was detected in all the distillers grains co-products surveyed in this study. Corn condensed distillers solubles contained the highest concentration of EC, ranging from 1618 to 2956 ng/g. Concentrations of EC in other types of distillers grains co-products varied from 17 to 917 ng/g. Cattle fed distillers grains co-products that constituted 19–38% of the total feed (as-fed) were found to contain 2–3 ng/mL of EC in blood plasma. No EC was detected in blood plasma from grass-fed control cattle.

show abstract

“…In feedlot cattle being fed a high grain diet 3-methyl indole has been targeted as the causative agent of feedlot AIP, but past research has demonstrated inconsistent results 5,6 . The amount of ltryptophan in high grain diets may not be high enough to create enough 3-MI to be toxic, leading the field to consider the cause of feedlot AIP to be multifactorial 7 .…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by GC-MS

Yao¹,

Maloley²,

Broeckling³

et al. 2020

Preprint

View full text Add to dashboard Cite

ABSTRACT : Ethyl carbamate (EC) is a fermentation byproduct in foods and beverages and classified as a Group 2A probable human carcinogen. Each year greater than 40 million metric tons of fermentation co-products from the U.S. ethanol industry are fed to food animals. A GC-MS assay was developed to analyze EC extracted from various distillers grains co-products with a limit of detection at 0.7 ng/g. EC was detected in all the distillers grains co-products surveyed in this study. Corn condensed distillers solubles contained the highest level of EC ranging from 1618 to 2956 ng/g. The levels of EC in the semi-solid co-products varied from 17 to 917 ng/g. Cattle fed on these fermentation co-products were found to contain 2-3 ng/mL of EC in blood plasma. No EC was detected in control animal blood plasma. The presence of EC in animal feeds and subsequently in animals may pose an animal health risk.

show abstract

Feedlot Acute Interstitial Pneumonia

Cited by 13 publications

References 22 publications

Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease

Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease

Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by Gas Chromatography–Mass Spectrometry

Quantitative Analysis of Ethyl Carbamate in Distillers Grains Co-products and Bovine Plasma by GC-MS

Contact Info

Product

Resources

About