Feeling smart: Effects of caffeine and glucose on cognition, mood and self-judgment

Ullrich, Susann; Vries, Y.C. de; Kühn, Simone; Repantis, Dimitris; Dresler, Martin; Ohla, Kathrin

doi:10.1016/j.physbeh.2015.08.028

Cited by 49 publications

(35 citation statements)

References 64 publications

(74 reference statements)

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“…According to the Centre for Addiction and Mental Health, the average Canadian consumes 210‐238 mg/d of caffeine . After consumption, caffeine is quickly absorbed through the gastrointestinal tract and the highest blood caffeine concentration is reached 30‐60 minutes after intake . Similar caffeine concentrations are found in the brain, suggesting that caffeine can readily cross the blood‐brain barrier, due to its hydrophobic nature.…”

Section: Caffeinementioning

confidence: 85%

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The neuroprotective effects of caffeine in neurodegenerative diseases

2017

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Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men with Parkinson's disease (PD); however, the effect of caffeine in female PD patients is controversial due to caffeine's competition with estrogen for the estrogen-metabolizing enzyme, CYP1A2. Studies conducted in animal models of amyotrophic lateral sclerosis (ALS) showed protective effects of A R antagonism. A study found caffeine to be associated with earlier age of onset of Huntington's disease (HD) at intakes >190 mg/d, but studies in animal models have found equivocal results. Caffeine is protective in AD and PD at dosages equivalent to 3-5 mg/kg. However, further research is needed to investigate the effects of caffeine on PD in women. As well, the effects of caffeine in ALS, HD and Machado-Joseph disease need to be further investigated. Caffeine's most salient mechanisms of action relevant to neurodegenerative diseases need to be further explored.

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Section: Caffeinementioning

confidence: 85%

“…Caffeine (1,3,7‐trimethylxanthine) is the most widely used psychostimulant in Western countries . It is contained in coffee, tea, energy drinks, several soft drinks and cocoa . In a cup containing 437 mL of brewed coffee, there is on average 188 mg of caffeine (range 147‐259 mg) .…”

Section: Caffeinementioning

confidence: 99%

The neuroprotective effects of caffeine in neurodegenerative diseases

2017

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“…Caffeine is a plant alkaloid that is quickly absorbed and found in food and drinks such as coffee, tea, energy drinks, soft drinks, and chocolate [93]; peak caffeine concentrations are reached between 15 and 120 min after ingestion [94,95]. The energising and concentration boosting qualities of caffeine are well-known and are the reason caffeine is the most commonly used psychostimulant [41,96]. A growing body of literature has investigated the effects of caffeine on cognitive performance, particularly during/after sleep deprivation.…”

Section: Caffeinementioning

confidence: 99%

A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel

Pomeroy¹,

Tooley²,

Probert³

et al. 2020

Nutrients

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Intake of dietary supplements has increased, despite evidence that some of these have adverse side effects and uncertainty about their effectiveness. This systematic review examined the evidence for the cognitive benefits of a wide range of dietary supplements in healthy young adult samples; the aim was to identify if any might be useful for optimising cognitive performance during deployment in military personnel. Searches were conducted in 9 databases and 13 grey literature repositories for relevant studies published between January 2000 and June 2017. Eligible studies recruited healthy young adults (18–35 years), administered a legal dietary supplement, included a comparison control group, and assessed cognitive outcome(s). Thirty-seven of 394 identified studies met inclusion criteria and were included for synthesis. Most research was deemed of low quality (72.97%; SIGN50 guidelines), highlighting the need for sound empirical research in this area. Nonetheless, we suggest that tyrosine or caffeine could be used in healthy young adults in a military context to enhance cognitive performance when personnel are sleep-deprived. Caffeine also has the potential benefit of improving vigilance and attention during sustained operations offering little opportunity for sleep. Inconsistent findings and methodological limitations preclude firm recommendations about the use of other specific dietary supplements.

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“…beschrieben [33,35]. Auf subjektiver Ebene führt Koffeingebrauch bei den Nutzern zu einer verbesserten Einschätzung der kognitiven Leistungsfähigkeit, auch bei Fehlen entsprechender objektiver Verbesserungen [35,154]. Ebenfalls wurde eine Verbesserung der Stimmung von einigen Nutzern nach akuter Anwendung von Koffein berichtet [137,[155][156][157].…”

Section: Objektive Und Subjektive Effekte Von Koffeinunclassified

Koffein, das am häufigsten konsumierte Psychostimulans: eine narrative Übersichtsarbeit

Gahr

2019

Fortschr Neurol Psychiatr

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ZusammenfassungKoffein ist das weltweit am häufigsten konsumierte Psychostimulans. Es ist nahezu unbeschränkt verfügbar und unterliegt in Europa keiner staatlichen Regulation. Neben seiner primären Rolle als Inhalts- oder Zusatzstoff in zahlreichen Getränken findet es auch medizinische Verwendung in der adjuvanten Schmerztherapie, bei primärem Atemstillstand bei Neugeborenen und es ist zugelassen für die kurzfristige Beseitigung von Ermüdungserscheinungen. Der Wirkmechanismus von Koffein als Psychostimulans in typischerweise aufgenommen Dosierungen basiert vermutlich in erster Linie auf einem zentralen Antagonismus von Adenosinrezeptoren (A1- und A2A-Rezeptoren), was zu einer zentralen Hemmung der Adenosin-vermittelten Reduktion der Aktivität des dopaminergen und aufsteigenden Aktivierungssystems führt. Die Metabolisierung von Koffein ist hautsächlich abhängig von Cytochrom P450 1A2, sodass Faktoren, die die Aktivität von CYP 1A2 beeinflussen (z. B. Medikamente, Schwangerschaft), erhebliche Veränderungen der pharmakokinetischen Parameter induzieren können. Koffein führt insbesondere bei Individuen mit Schlafentzug zu einer Verbesserung der Vigilanz, Aufmerksamkeit und Reaktionszeit. Zudem kann es sportliche Ausdauerleistungen und muskuläre Kraft verbessern. Intoxikationen mit Koffein sind selten, können jedoch letal verlaufen. In üblicherweise aufgenommenen Mengen gilt Koffeingebrauch als nicht gesundheitsschädlich. Koffein weist zahlreiche, jedoch nicht alle Merkmale einer Substanz mit „Abhängigkeitspotential“ auf; Entzugssyndrome nach Beendigung einer längeren Anwendung und Toleranz sind bekannt. Im DSM-5 wird die „Koffeingebrauchsstörung“ als mögliche künftige Störung, die gegenwärtig weiterer Forschung bedarf, rubriziert. Das Koffeingebrauchsmuster von Patienten sollte im Rahmen der ärztlichen Tätigkeit berücksichtigt werden.

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Feeling smart: Effects of caffeine and glucose on cognition, mood and self-judgment

Cited by 49 publications

References 64 publications

The neuroprotective effects of caffeine in neurodegenerative diseases

The neuroprotective effects of caffeine in neurodegenerative diseases

A Systematic Review of the Effect of Dietary Supplements on Cognitive Performance in Healthy Young Adults and Military Personnel

Koffein, das am häufigsten konsumierte Psychostimulans: eine narrative Übersichtsarbeit

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