?Feet of Clay?: Organisational Culture and Localism

Ludwig, Gregory; Ludwig, Carol

doi:10.4172/2151-6219.1000123

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Anchoring on the clock to schedule activities still feels unnatural for much of the world today (Levine, 1997). For example, in the Arab world, it is common to arrive at a meeting whenever one is ready to attend it, rather than at a specific time; it is also considered rude to look at one’s watch during a meeting (Ludwig, 2010).…”

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confidence: 99%

So what if the clock strikes? Scheduling style, control, and well-being.

Sellier¹,

Avnet²

2014

Journal of Personality and Social Psychology

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Individuals vary in the way they schedule their daily tasks and activities. In particular, 2 scheduling styles are commonly followed: clock-time (where tasks are organized based on a clock) and event-time (where tasks are organized based on their order of completion). This research shows that adopting a clock-time or an event-time scheduling style has consequences that go beyond the direct effect on task organization. In particular, adopting 1 scheduling style versus the other is shown to potentially influence personal control and well-being. We demonstrate that the reliance on clock- versus event-time affects individuals' perception of the causal relationship between events in the social world (Experiments 1 and 2). Specifically, we show that individuals following clock-time rather than event-time discriminate less between causally related and causally unrelated events, which in turn increases their belief that the world is controlled by chance or fate. In contrast, individuals following event-time (vs. clock-time) appear to believe that things happen more as a result of their own actions. We further show that this difference in internal locus of control compromises the ability of individuals following clock-time to savor positive emotions (Experiments 3a-5). We discuss the implications of these findings for future research in social and cognitive psychology.

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confidence: 99%

So what if the clock strikes? Scheduling style, control, and well-being.

Sellier¹,

Avnet²

2014

Journal of Personality and Social Psychology

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“…Following deprotection, the resulting X nucleoside analogs were converted to triphosphates using standard Ludwig phosphorylation conditions (see Supporting Information). 28 NaMTP and MMO2TP were synthesized as reported previously. 29 The synthesis of the YTP analogs generally proceeded via intramolecular Curtius rearrangement of the corresponding acyl azide, followed by Lewis-acid mediated coupling to 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose, resulting in pure β-anomer of the desired protected nucleoside.…”

Section: Synthesis and First Sar Analysis Of Ribonucleotide Candidatesmentioning

confidence: 99%

Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism

et al. 2019

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Previously, we reported the creation of a semi-synthetic organism (SSO) that stores and retrieves increased information by virtue of stably maintaining an unnatural base pair (UBP) in its DNA, transcribing the corresponding unnatural nucleotides into the codons and anticodons of mRNAs and tRNAs, and then using them to produce proteins containing non-canonical amino acids (ncAAs). Here we report a systematic extension of the effort to optimize the SSO by exploring a variety of deoxy-and ribonucleotide analogs. Importantly, this includes the first in vivo structureactivity relationship (SAR) analysis of unnatural ribonucleoside triphosphates. Similarities and differences between how DNA and RNA polymerases recognize the unnatural nucleotides were observed, and remarkably, we found that a wide variety of unnatural ribonucleotides can be efficiently transcribed into RNA and then productively and selectively paired at the ribosome to mediate the synthesis of proteins with ncAAs. The results extend previous studies, demonstrating that nucleotides bearing no significant structural or functional homology to the natural nucleotides can be efficiently and selectively paired during replication, to include each step of the entire process of information storage and retrieval. From a practical perspective, the results identify the most optimal UBP for information storage, as well as the most optimal unnatural ribonucleoside triphosphates for its retrieval. The optimized SSO is now, for the first time, able to efficiently produce proteins containing multiple, proximal ncAAs.

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“…Graph-based representations have been successfully applied to predict molecular properties. 31,32 Meanwhile, many symmetric functions based on interatomic distances have been developed, [33][34][35][36][37] which are equally applicable to very different systems such as bulk metals, clusters or molecules. However, graph-based representations may neglect some geometric details, such as distortion, whereas symmetric function models often contain too complex structural detail and are frequently computationally intractable, due to its rather complicated conversion formula.…”

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confidence: 99%