Feline glaucoma—a comprehensive review

McLellan, Gillian J.; Miller, Paul E.

doi:10.1111/j.1463-5224.2011.00912.x

Cited by 74 publications

(82 citation statements)

References 65 publications

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“…IOP values above the normal range are indicative of glaucoma, and values below the normal range are indicative of uveitis (COLITZ, 2005;MILLER, 2011;SHUKLA;PINARD, 2012;STILES, 2013), which agrees with the observations of this study. In the ambulatory study, the mean IOP value measured with the Kowa HA-2 tonometer for the eyes with clinical signs of glaucoma was 38.4 ± 8.1 mmHg (29.6 -53.7), which was above the measured value in the healthy eyes (15.0 ± 1.5 mmHg).…”

Section: Discussionsupporting

confidence: 82%

“…The pathophysiological process of glaucomatous optic neuropathy is likely to be a multifactorial event. An increase in IOP is the principal risk factor for glaucoma, and the primary goal of treatment is to reduce IOP to a value that prevents the death of retinal ganglion cells (XU et al, 2014;STRUEBING;GEISERT, 2015;TEIXEIRA et al, 2014;MILLER, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Ex vivo and in vivo study of Kowa HA-2 applanation tonometer in the measurement of intraocular pressure in cats

Ricci

Giuffrida

Kanashiro

et al. 2017

SCA

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The objective of this study was to evaluate the use of the Kowa HA-2 applanation tonometer in measuring intraocular pressure (IOP) in cats. Ten healthy eyes were used in an ex vivo study in which the calibration curve for manometry vs. tonometry was determined by artificially raising the IOP in 5 mmHg increments up to 60 mmHg (10-60 mmHg). Both eyes of 10 anesthetized cats were studiedin vivo to compare manometry vs. tonometry. In the ambulatory study, 78 healthy eyes, 7 eyes with glaucoma and 20 eyes with uveitis were evaluated by tonometry, which was performed with topical anesthesia and 1% fluorescein eye drops for the formation of fluorescein semicircles. The correlation coefficient (r²) between the manometer and the Kowa HA-2 tonometer was 0.993 and the linear regression equation was y = 0.0915x + 0.0878 in the ex-vivo study. In the in vivo study, the IOP values (mean±SD, in mmHg) in manometry were 15.6 ± 1.1(14.0 -17.5) and in tonometry were 15.5 ± 1.2(13.5 -17.2), with no significant difference (P > 0.05) between manometry and tonometry. In ambulatory study, using the Kowa HA-2 tonometer, the IOP values (mean±SD, in mmHg) were 15.0 ± 1.5 (11.8 -18.3) for the healthy eyes, 38.4 ± 8.1(29.6 -53.7) for glaucomatous eyes and 10.4 ± 2.0(5.3 -12.2) for eyes with uveitis. There was a strong correlation and accuracy between the IOP values with the manometry and the Kowa HA-2 tonometer. In the ambulatorystudy the IOP values obtained with the tonometer were compatible for animals with healthy eyes and with clinical signs of glaucoma and uveitis. We conclude that the Kowa HA-2 tonometer can be used in the measurement of IOP in cats, since it is a practical and accurate method in this species. Key words: Applanation tonometer. Ocular manometry. Intraocular pressure. Cats. ResumoO objetivo deste estudo foi avaliar o uso do tonômetro de aplanação Kowa HA-2 na aferição da pressão intraocular (PIO) em gatos. Dez olhos saudáveis foram utilizados em um estudo ex vivo no qual a curva de calibração para manometria versus tonometria foi determinada por elevação artificial da PIO em incrementos de 5 mmHg até 60 mmHg (10-60 mmHg). Ambos os olhos de 10 gatos anestesiados foram utilizados no estudo in vivo para comparar a manometria versus a tonometria. No estudo ambulatorial, 78 olhos saudáveis, 7 olhos com glaucoma e 20 olhos com uveíte foram avaliados pela tonometria, que foi realizada com anestesia tópica e colírio de fluoresceína a 1% para a formação de semicírculos de fluoresceína. O coeficiente de correlação (r²) entre o manômetro e o tonômetro Kowa HA-2 foi de 0,993 e a equação de regressão linear foi y = 0,0915x + 0,0878 no estudo ex-vivo. No estudo in vivo, os valores de PIO (média ± DP, em mmHg) na manometria foram de 15,6 ± 1,1(14.0 -17.5) e na tonometria foi de 15,5 ± 1,2(13.5 -17.2), sem diferença significativa (P > 0,05) entre manometria e tonometria. No estudo ambulatorial, com o tonômetro Kowa HA-2, os valores de PIO (média ± DP, em mmHg) foram 15,0 ± 1,5(11.8-18.3) para os olhos saudáveis, 38,4 ± 8,1(29.6...

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Ex vivo and in vivo study of Kowa HA-2 applanation tonometer in the measurement of intraocular pressure in cats

Ricci

Giuffrida

Kanashiro

et al. 2017

SCA

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“…However, this should not be translated to medical treatment of glaucoma in small animals. In view of the previously cited results of , the side effects in general preclude the use of apraclonidine in cats (McLellan and Miller 2011). Considering the results of a retrospective study reported by the ASPCA Animal Poison Control Center (Welch and Richardson 2002), the administration safety of 0.2% brimonidine in dogs also raises doubts.…”

Section: Clinical Usementioning

confidence: 92%

“…No significant additive ocular effect was detected in normotensive cats treated with a combination of dorzolamide (2%) and timolol (0.5%) relative to the IOP-lowering effect of treatment with dorzolamide alone (Dietrich et al 2007). These data indicate that a CAI alone can maximally suppress AH formation in cats (McLellan and Miller 2011). As β 2 -adrenergic receptors predominate in the feline anterior segment (Colasanti and Trotter 1981), β 1 -selective blockers, i.e.…”

Section: Effect On Iopmentioning

confidence: 98%

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Autonomic drugs in the treatment of canine and feline glaucoma – Part II: Medications that lower intraocular pressure by reducing aqueous humour production

Maślanka

2014

Polish Journal of Veterinary Sciences

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One characteristic of the most common types of glaucoma is increased intraocular pressure (IOP), which has a damaging effect on optic nerve axons, leading to progressive loss of retinal ganglion cells. Therefore, ocular hypotensive drugs are the mainstay of pharmacological therapy for glaucoma. This review article, which is the second part of a two-part series, is dedicated to autonomic drugs which lower IOP by decreasing the aqueous humour production. These agents are subdivided into two groups: β-adrenergic antagonists and selective α 2 -adrenergic agonists. This paper summarizes the current state of knowledge on the mechanism of action of these drugs and their effect on IOP in dogs and cats. Moreover, it discusses their possible undesirable side effects of these medications and presents the current ideas about their role and position in the medical management of glaucoma in small animals.

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Glaucoma

2015

Small Animal Ophthalmic Atlas and Guide

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Feline glaucoma—a comprehensive review

Cited by 74 publications

References 65 publications

Ex vivo and in vivo study of Kowa HA-2 applanation tonometer in the measurement of intraocular pressure in cats

Ex vivo and in vivo study of Kowa HA-2 applanation tonometer in the measurement of intraocular pressure in cats

Autonomic drugs in the treatment of canine and feline glaucoma – Part II: Medications that lower intraocular pressure by reducing aqueous humour production

Glaucoma

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