Feline Infectious Respiratory Disease

Gaskell, Rosalind M.; Radford, Alan; Dawson, Susan

doi:10.1002/9780470690727.ch22

Cited by 48 publications

(100 citation statements)

References 88 publications

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“…However, secondary bacterial infection may enhance the effect of the virus and may lead to bacterial pneumonia, or chronic rhinitis, sinusitis or conjunctivitis [39]. The role of FeHV-1 itself in chronic rhinosinusitis is not clear: a recent study in a small series of cats found no difference in the proportion of cases and controls in which FeHV-1 DNA was detected using PCR [61].…”

Section: Pathogenesismentioning

confidence: 98%

“…Most produce a relatively uniform disease although some show reduced or increased virulence [39,42]. Antigenically all isolates belong to one serotype, and they are relatively homogeneous on restriction enzyme analysis of their DNA [41,52].…”

Section: Aetiologymentioning

confidence: 99%

“…Infection of the respiratory epithelium leads to areas of multifocal epithelial necrosis with neutrophilic infiltration and fibrin exudation [14,15,39,56,108]; intranuclear inclusion bodies may be seen. Viral damage can also lead to osteolytic changes in the turbinate bones.…”

Section: Pathogenesismentioning

confidence: 99%

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Feline herpesvirus

et al. 2007

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Section: Pathogenesismentioning

confidence: 98%

Section: Aetiologymentioning

confidence: 99%

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Feline herpesvirus

et al. 2007

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“…Ulcers begin as vesicles, typically on the margin of the tongue but also in other locations. These subsequently rupture, with necrosis of the overlying epithelium and infiltration of neutrophils at the periphery and base [30]. Healing generally takes place over a period of two to three weeks.…”

Section: Fcv-associated Oral and Upper Respiratory Tract Diseasementioning

confidence: 99%

“…A more detailed description of the control measures for these two pathogens is given elsewhere [30]. Briefly, the control measures for FCVassociated respiratory disease depend entirely on the population of cats.…”

Section: Management Of Fcv-associated Respiratory Diseasementioning

confidence: 99%

Feline calicivirus

et al. 2007

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-Feline calicivirus (FCV) is an important and highly prevalent pathogen of cats. It belongs to the family Caliciviridae which includes other significant pathogens of man and animals. As an RNA virus, high polymerase error rates convey upon FCV a high genome plasticity, and allow the virus to respond rapidly to environmental selection pressures. This makes the virus very adaptable and has important implications for clinical disease and its control. Being genetically diverse, FCV is associated with a range of clinical syndromes from inapparent infections to relatively mild oral and upper respiratory tract disease with or without acute lameness. More recently, highly virulent forms of the virus have emerged associated with a systemic infection that is frequently fatal. A proportion of FCV infected cats that recover from acute disease, remain persistently infected. In such cats, virus evolution is believed to help the virus to evade the host immune response. Such longterm carriers may only represent a minority of the feline population but are likely to be crucial to the epidemiology of the virus. Vaccination against FCV has been available for many years and has effectively reduced the incidence of clinical disease. However, the vaccines do not prevent infection and vaccinated cats can still become persistently infected. In addition, FCV strain variability means that not all strains are protected against equally. Much progress has been made in understanding the biology and pathogenesis of this important feline virus. Challenges for the future will necessarily focus on how to control the variability of this virus particularly in relation to emerging virulent strains and vaccination.

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