Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases

Black, Vicki; Adamantos, Sophie; Barfield, Dominic; Tasker, Séverine

doi:10.1177/1098612x15588800

Cited by 25 publications

(45 citation statements)

References 12 publications

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“…A significant proportion of cases of PRCA and NRIMHA respond to glucocorticoid monotherapy. 5,44,81 In other bone marrow disorders, response is more variable.…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…Ciclosporin The most well studied and widely used adjuvant to or substitute for glucocorticoids is ciclosporin, and this drug has been used in cats with NRIMHA, PRCA and MDS. 5,80,81,84…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…A significant proportion of cases of PRCA and NRIMHA respond to glucocorticoid monotherapy. 5,44,81 In other bone marrow disorders, response is more variable. ✜ Ciclosporin The most well studied and widely used adjuvant to or substitute for glucocorticoids is ciclosporin, and this drug has been used in cats with NRIMHA, PRCA and MDS.…”

Section: Immunosuppressive Treatment Of Primary Medullary Causes Of Nmentioning

confidence: 99%

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Feline non-regenerative anemia: Diagnostic and treatment recommendations

Olson

Hohenhaus

2019

Journal of Feline Medicine and Surgery

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Practical relevance:Non-regenerative anemia, or anemia with reticulocytopenia, is a daily diagnosis in feline practice.Clinical challenges:The disease processes underlying non-regenerative anemia are many and diverse. A major diagnostic evaluation may be required to correctly diagnose and treat the underlying cause.Audience:All veterinarians caring for cats will face the diagnostic and therapeutic challenge of non-regenerative anemia. Readers will benefit from the review of diagnostic testing and therapeutic options for non-regenerative anemia.Evidence base:This review summarizes the currently available literature informing diagnostic and treatment recommendations related to non-regenerative anemia. The evidence available to support the recommendations in this review is graded as low and includes predominantly expert opinion, case reports and cases series, on which the authors’ interpretation/consensus is based.

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“…A significant proportion of cases of PRCA and NRIMHA respond to glucocorticoid monotherapy. 5,44,81 In other bone marrow disorders, response is more variable.…”

Section: Therapeutic Optionsmentioning

confidence: 99%

“…Ciclosporin The most well studied and widely used adjuvant to or substitute for glucocorticoids is ciclosporin, and this drug has been used in cats with NRIMHA, PRCA and MDS. 5,80,81,84…”

Section: Therapeutic Optionsmentioning

confidence: 99%

Section: Immunosuppressive Treatment Of Primary Medullary Causes Of Nmentioning

confidence: 99%

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Feline non-regenerative anemia: Diagnostic and treatment recommendations

Olson

Hohenhaus

2019

Journal of Feline Medicine and Surgery

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“…Most cats required long-term immunosuppressive treatment to maintain the disease in remission. [84][85][86] Two single case reports described the use of CsA in combination with immunosuppressive drugs at similar dosages to treat idiopathic, possibly immune-mediated, thrombocytopenia and immune-mediated granulocytopenia associated with thymoma. 87,88 Feline stomatitis CsA has been reported to be effective in feline gingivostomatitis.…”

Section: Haematological Diseasesmentioning

confidence: 99%

Ciclosporin and the cat: Current understanding and review of clinical use

Colombo¹,

Sartori²

2018

Journal of Feline Medicine and Surgery

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This review will be of interest to all veterinarians working with cats, given the wide range of potential applications of CsA and its safety profile. Although the drug is currently only licensed to treat chronic allergic dermatitis in cats, a small number of reports describe its use in non-dermatological conditions. Evidence base: This article reviews the mechanism of action, pharmacokinetics, drug interactions, adverse effects and clinical use of CsA, both for the licensed indication and for off-label use in the feline patient. Information presented has been summarised from the existing literature on CsA, with specific interest in studies carried out in cats. For its licensed indication, chronic allergic dermatitis, evidence provided includes randomised, placebo or prednisolone-controlled studies (EBM grade I) and prospective or retrospective open trials.

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“…Chlorambucil wird häufig bei der Katze z. B. zur Therapie des niedrigmalignen Lymphoms, aber auch bei chronisch entzündlichen Darmerkrankungen, IMTP und nichtregenerativen Anämien eingesetzt (18,97,108). Zu den Nebenwirkungen gehören in erster Linie Myelosuppression und Magen-Darm-Probleme (108).…”

Section: Alkylanzienunclassified

Immunsuppressive Therapie bei Hunden und Katzen. Eigenschaften von Wirkstoffen und ihre Anwendung bei verschiedenen immunvermittelten Erkrankungen

Rieder¹,

Mischke²

2018

Tierarztl Prax Ausg K

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ZusammenfassungTierärzte werden regelmäßig mit der Diagnose und Therapie immunvermittelter Erkrankungen konfrontiert. Zu den häufigeren Erkrankungen gehören die immunvermittelte hämolytische Anämie, die immunvermittelte Thrombozytopenie und Polyarthritis. Aufgrund ihrer Verfügbarkeit, Effizienz und schnellen Wirkung sind Glukokortikoide Mittel der ersten Wahl. Einige Patienten mit immunvermittelten Erkrankungen sprechen jedoch nicht auf eine alleinige Therapie mit Glukokortikoiden an. Bei anderen Patienten muss infolge schwerwiegender Nebenwirkungen zeitnah eine Dosisreduktion der Glukokortikoide erfolgen. In solchen Fällen ist die Anwendung ergänzender Medikamente indiziert. Für Ciclosporin gibt es zugelassene Präparate in der Veterinärmedizin. In der Literatur ist auch der Einsatz von Azathioprin, Mycophenolat-Mofetil und humanen Immunglobulinen beschrieben. Der Artikel gibt einen Überblick über die Wirkmechanismen einzelner immunmodulierender Substanzen sowie deren in der aktuellen Literatur beschriebenen Einsatz bei ausgewählten Erkrankungen.

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Feline non-regenerative immune-mediated anaemia: features and outcome in 15 cases

Cited by 25 publications

References 12 publications

Feline non-regenerative anemia: Diagnostic and treatment recommendations

Feline non-regenerative anemia: Diagnostic and treatment recommendations

Ciclosporin and the cat: Current understanding and review of clinical use

Immunsuppressive Therapie bei Hunden und Katzen. Eigenschaften von Wirkstoffen und ihre Anwendung bei verschiedenen immunvermittelten Erkrankungen

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