Feline Peripheral Nerve Sheath Tumors

Abstract

Abstract. Feline peripheral nerve sheath tumors are uncommonly reported, and their clinical behavior has not been well documented. Fifty-nine peripheral nerve sheath tumors were collected from 53 cats. All of the tumors involved skin, subcutis, skeletal muscle, and/or mucous membranes. Histologically, the tumors were composed of compact to loosely arranged streams and fascicles of spindled cells with eosinophilic, often wavy cytoplasmic processes; small to occasionally moderate amounts of collagenous to myxoid matrix; and nuclear palisading. Immunohistochemically, all tumors were positive for vimentin and S-100 protein, 44 of 59 were positive for glial fibrillary acidic protein (GFAP), and all were negative for muscle specific actin. The tumors fell into 3 histologic categories: 34 benign tumors with Antoni A areas that were S-100 protein and GFAP positive, 9 benign tumors that lacked Antoni A areas and were S-100 protein positive and GFAP negative, and 16 tumors with features of malignancy. Seventy-five percent of these cases involved the head, neck, or limbs. Recurrent tumors were submitted or tumors were reported to have recurred in 9 cases. Tumor recurrence was reported for all 3 of the histologic subtypes. None was documented as having metastasized.

Retraction Note: Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

“…An investigation by the Publisher found it to be one of a group of articles we have identified as showing evidence suggestive of attempts to subvert the peer review and publication system to inappropriately obtain or allocate authorship. This article showed evidence of plagiarism (most notably from the articles cited [2–6]) and peer review and authorship manipulation.…”

Marginal resection and adjuvant strontium plesiotherapy in the management of feline eyelid malignant peripheral nerve sheath tumours: two cases

“…The most common immunohistochemical marker used to support the morphological diagnosis of PNSTs is S100, which is expressed in up to 100% of cases. 2 …”

“…2 There were 43 benign PNSTs and 16 malignant PNSTs. The overall recurrence rate in the study was 23% (13/57).…”

Malignant Epithelioid Schwannoma of the Oral Cavity in a Cat

“…Verocay bodies are rows of nuclear arrangements that are separated by anuclear zones of eosinophilic fibrillar material and are common in Antoni A areas; these are also seen in feline tumors [14]. Like a conventional schwannoma, epithelioid variants of schwannoma develop as a circumscribed and encapsulated mass, but Antoni A and B patterns are not observed in the epithelioid population as this case.…”

“…Schwannomas (peripheral nerve sheath tumors) are common tumors of the peripheral nervous system of domestic animals and have been reported in dogs [3], cats [14], horses [13] and cows [15]. By contrast, malignant epithelioid schwannoma is an unusual variant of peripheral nerve sheath tumor that closely resembles carcinoma or melanoma because the tumor comprises exclusively Schwann cells with a polygonal epithelioid appearance [1, 8].…”