Felinine excretion in domestic cat breeds: a preliminary investigation

Hagen-Plantinga, E.A.; Bosch, G.; Hendriks, W.H.

doi:10.1111/jpn.12097

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is likely that a strong selection pressure exists to retain such an important class of compounds, so to secrete them as an honest signal [64] may require a compensation in metabolism (alterations in anti-oxidants derived from tryptophan, histidine and tocopherol metabolism) to secure sufficient functionality to maintain cat health status. The physiological compromises to maintain S-amino acid balance is supported by preliminary findings indicating that entire males of long-haired cat breeds may have reduced urinary felinine due to the increased requirement for cysteine in hair growth [65]. …”

Section: Discussionmentioning

confidence: 99%

Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats

Allaway¹,

Gilham²,

Colyer³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

Neutering is a significant risk factor for obesity in cats. The mechanisms that promote neuter-associated weight gain are not well understood but following neutering, acute changes in energy expenditure and energy consumption have been observed. Metabolic profiling (GC-MS and UHPLC-MS-MS) was used in a longitudinal study to identify changes associated with age, sexual development and neutering in male cats fed a nutritionally-complete dry diet to maintain an ideal body condition score. At eight time points, between 19 and 52 weeks of age, fasted blood samples were taken from kittens neutered at either 19 weeks of age (Early Neuter (EN), n = 8) or at 31 weeks of age (Conventional Neuter (CN), n = 7). Univariate and multivariate analyses were used to compare plasma metabolites (n = 370) from EN and CN cats. Age was the primary driver of variance in the plasma metabolome, including a developmental change independent of neuter group between 19 and 21 weeks in lysolipids and fatty acid amides. Changes associated with sexual development and its subsequent loss were also observed, with differences at some time points observed between EN and CN cats for 45 metabolites (FDR p<0.05). Pathway Enrichment Analysis also identified significant effects in 20 pathways, dominated by amino acid, sterol and fatty acid metabolism. Most changes were interpretable within the context of male sexual development, and changed following neutering in the CN group. Felinine metabolism in CN cats was the most significantly altered pathway, increasing during sexual development and decreasing acutely following neutering. Felinine is a testosterone-regulated, felid-specific glutathione derivative secreted in urine. Alterations in tryptophan, histidine and tocopherol metabolism observed in peripubertal cats may be to support physiological functions of glutathione following diversion of S-amino acids for urinary felinine secretion.

show abstract

Section: Discussionmentioning

confidence: 99%

Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats

Allaway¹,

Gilham²,

Colyer³

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…However, there are recognized issues with this chemical for health (Peddie et al, 1982;Sales and Janssens, 2003) and consistency in results (Moore, 1957;Jagger et al, 1992). Titanium dioxide (TiO 2 ) has been evaluated in a number of studies with pets (Lôbo-Junior et al, 2001;Childs-Sanford et al, 2006;Hagen-Plantinga et al, 2014) and other animal species (Peddie et al, 1982;Jagger et al, 1992;Titgemeyer et al, 2001;Smeets et al, 2015) with good results. It also has the advantage over Cr 2 O 3 of being a food color additive incorporated in food up to 1% (Code of Federal Regulations, 2015), so there are fewer concerns regarding animal and worker safety.…”

Section: Introductionmentioning

confidence: 99%

223 Comparison of four digestibility markers to estimate fecal output of dogs

Alvarenga

Aldrich

2017

Journal of Animal Science

View full text Add to dashboard Cite

Twelve adult beagle dogs (10.6 ± 1.4 kg) were fed extruded dog diets in which the starch sources were whole sorghum, sorghum flour, sorghum mill-feed, or an equal combination of rice, corn, and wheat. The experiment was conducted as a replicated Latin square design digestibility study. Estimates of fecal organic matter (OM), crude protein (CP), crude fat (CF), and gross energy (GE) outputs were determined by four methods: total fecal collection (TFC), chromic oxide (Cr 2 O 3 ), titanium dioxide (TiO 2 ), and acid insoluble ash (AIA). The correlation among the fecal output estimates by the four methods by partial correlation coefficients from the Error SSCP Matrix (Pearson) were considered significant at P < 0.05. The external markers, Cr 2 O 3 and TiO 2 , had a higher (P < 0.05) OM fecal output Pearson correlation to TFC than the intrinsic marker AIA (R = 0.931 for Cr 2 O 3 vs. TiO 2 ; R = 0.559 for TFC vs. Cr 2 O 3 ; R = 0.592 for TFC vs. TiO 2 ; R = 0.291 for AIA vs. TFC). Interestingly, TiO 2 highly correlated (P < 0.05) to Cr 2 O 3 (R = 0.93 for OM), and was also correlated highly to TFC and AIA. The study suggests that TiO 2 may be a preferred marker to estimate fecal output in dogs vs. Cr 2 O 3 . The use of AIA represents a potential option for determining digestibility for diets in which external markers are impractical.

show abstract

Comparison of four digestibility markers to estimate fecal output of dogs

Alvarenga

Aldrich

2019

Journal of Animal Science

View full text Add to dashboard Cite

Twelve adult beagle dogs (10.6 ± 1.4 kg) were fed extruded dog diets in which the starch sources were whole sorghum, sorghum flour, sorghum mill-feed, or an equal combination of rice, corn, and wheat. The experiment was conducted as a replicated Latin square design digestibility study. Estimates of fecal organic matter (OM), crude protein (CP), crude fat (CF), and gross energy (GE) outputs were determined by four methods: total fecal collection (TFC), chromic oxide (Cr 2 O 3 ), titanium dioxide (TiO 2 ), and acid insoluble ash (AIA). The correlation among the fecal output estimates by the four methods by partial correlation coefficients from the Error SSCP Matrix (Pearson) were considered significant at P < 0.05. The external markers, Cr 2 O 3 and TiO 2 , had a higher ( P < 0.05) OM fecal output Pearson correlation to TFC than the intrinsic marker AIA ( R = 0.931 for Cr 2 O 3 vs. TiO 2 ; R = 0.559 for TFC vs. Cr 2 O 3 ; R = 0.592 for TFC vs. TiO 2 ; R = 0.291 for AIA vs. TFC). Interestingly, TiO 2 highly correlated ( P < 0.05) to Cr 2 O 3 ( R = 0.93 for OM), and was also correlated highly to TFC and AIA. The study suggests that TiO 2 may be a preferred marker to estimate fecal output in dogs vs. Cr 2 O 3 . The use of AIA represents a potential option for determining digestibility for diets in which external markers are impractical.

show abstract

Felinine excretion in domestic cat breeds: a preliminary investigation

Cited by 3 publications

References 16 publications

Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats

Metabolic Profiling Reveals Effects of Age, Sexual Development and Neutering in Plasma of Young Male Cats

223 Comparison of four digestibility markers to estimate fecal output of dogs

Comparison of four digestibility markers to estimate fecal output of dogs

Contact Info

Product

Resources

About