Female obesity impairs in vitro fertilization outcome without affecting embryo quality

Bellver, José; Ayllón, Yanira; Ferrando, Marcos; Melo, Marco; Goyri, Eduardo; Pellicer, António; Remohı́, José; Meseguer, Marcos

doi:10.1016/j.fertnstert.2008.12.032

Cited by 323 publications

(249 citation statements)

References 47 publications

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“…The quality of embryos is frequently utilized to predict implantation rates and subsequent clinical pregnancy rates. Similar to prior studies [15,16,20, 21], we did not observe a significant difference in embryo morphology at the cleavage stage. However, we did observe a statistically significant decline in blastocyst formation rate in patients who were overweight/obese versus normal-weight controls (43.6 versus 57.2 %, respectively).…”

Section: Discussionsupporting

confidence: 91%

“…This trend is consistent with other studies examining the effect of BMI on pregnancy, live birth, and miscarriage rates which have found similar associations [9,11,20,29,30]. Rittenberg et al [30] reported a significantly lower live birth rate in patients with a BMI ≥25 kg/m 2 when compared to patients with a normal BMI (64 versus 81 %, p=0.005).…”

Section: Discussionsupporting

confidence: 87%

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Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock

Kim

Behr

et al. 2015

J Assist Reprod Genet

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Purpose The aim of this study is to investigate the effect of female BMI and metabolic dysfunction on blastocyst formation rate. Methods This was a retrospective cohort study that was performed in an academic center for reproductive medicine. Patients who were normal weight, overweight with metabolic dysfunction, or obese who had ≥6 oocytes retrieved in a fresh IVF cycle were included in the study. The blastocyst formation rate was calculated from the number of ≥5 cell embryos on day 3 observed in culture until day 5 or day 6. Only good quality blastocysts were included in the calculation as defined by a morphologic grade of 3BB or better. Results The blastocyst formation rate was significantly better in the normal-weight controls versus overweight/obese patients (57.2 versus 43.6 %, p<0.007). There was no difference in blastocyst formation between the patients with a BMI 25-29.9 kg/m 2 with metabolic dysfunction and those with a BMI ≥30 kg/m 2 . Conclusion The maternal metabolic environment has a significant impact on embryo quality as measured by blastocyst formation. A decreased blastocyst formation rate is likely a significant contributor to poorer reproductive outcomes in overweight and obese women with infertility.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Comstock

Kim

Behr

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Zhang et al, 2010, showed that the dose in patients with BMI in the normal range was 2587 ± 933 and 3272 ± 1798 in obese (p < 0.05). In Bellver et al, 2010, this result was also found with p value of 0.001. In Erel et al, 2009 review, several articles were evaluated.…”

Section: Dose Of Gonadotropinssupporting

confidence: 61%

Obese women and in vitro fertilization: results

Koatz¹,

Souza²

2013

JBRA Assisted Reproduction

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Objective: To evaluate the effect of female obesity on the results of In Vitro Fertilization (IVF) in six parameters: dose of gonadotropins required, number of oocytes retrieved and fertilization, pregnancy, miscarriage and live births rates. method: Literature search in PUBMED articles in English between 2008 and 2013 using the following keywords: female, obesity and In Vitro Fertilization. 15 articles were selected for this work. Results: From the total only two articles showed that female obesity does not alter the results of IVF. The remaining 13 came to the conclusion that obesity has a negative effect on some of the parameters evaluated. However, there was no consensus about its effect. Conclusion: Further studies are needed to clarify the real role of obesity in female patients undergoing IVF, but the weight loss prior to treatment should always be encouraged. keywords: Female, Obesity and In Vitro Fertilization. RESUmOObjetivo: Avaliar o efeito da obesidade feminina nos resultados da fertilização in vitro (FIV) em seis parâmetros: recuperados e fertilização, gravidez, aborto e taxas de nascidos vivos. método: Inglês, entre 2008 e 2013, utilizando as seguintes palavraschave: mulher, obesidade e fertilização in vitro. 15 artigos foram selecionados para este trabalho. Resultados: Do total apenas dois artigos mostraram que a obesidade feminina não altera os resultados de fertilização in vitro. Os restantes 13 chegaram à conclusão de que a obesidade tem um efeito negativo sobre alguns dos parâmetros avaliados. no entanto, não houve consenso sobre o seu efeito. Conclusão: Mais estudos são necessários para esclarecer o real papel da obesidade em pacientes do sexo feminino submetidas a fertilização in vitro, mas a perda de peso antes do tratamento deve ser sempre incentivada. Palavras-chave: feminino, obesidade e fertilização in vitro.

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“…Thus, our findings that obesity was associated with lower implantation rates and higher spontaneous abortion rates are similar to those described in the literature [17][18][19][20][21]. It has been suggested that the adverse effects of obesity on IVF outcomes may be attributed to the alteration in the uterine environment [22,23]. Furthermore, increased levels of inflammatory markers such as interleukin-6 and tumor necrosis factor-α found in obese women may negatively impact implantation and early embryonic development [24][25][26].…”

Section: Discussionsupporting

confidence: 89%

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

Irani

Robles

Gunnala

et al. 2016

Fertility and Sterility

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Background: There is no consensus on the exact parameters that define the LH surge for natural cycle frozenthawed embryo transfers (NC-FET). Accurately determining the LH surge would affect the timing, and subsequently the success rates, of embryo transfer. Therefore, the aim of this study was to delineate the optimal levels and relationship for luteinizing hormone (LH) and estradiol in an effort to optimally identify the LH surge in NC-FET.

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Female obesity impairs in vitro fertilization outcome without affecting embryo quality

Cited by 323 publications

References 47 publications

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Increased body mass index negatively impacts blastocyst formation rate in normal responders undergoing in vitro fertilization

Obese women and in vitro fertilization: results

Optimal parameters for determining the LH surge in natural cyclefrozen-thawed embryo transfers

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