Female Pattern Hair Loss: An Overview with Focus on the Genetics

Ho, Chung Liang; Chen, Jeff Yi‐Fu; Hsu, Wen-Li; Yu, Sebastian; Chen, Wei-Chiao; Chiu, Szu-Hao; Yang, Huiru; Lin, Sheng-Yao; Wu, Chieh‐Shan

doi:10.3390/genes14071326

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…Among all types of non-cicatricial alopecia, AGA is the most common worldwide, affecting at least 50% of both males and females by the age of 60. 13,14 It manifests differently in male and female patients. In males, the shedding area is mostly in the frontal and vertex parts, whereas in females, the hair is thin in the diffusing pattern at the central scalp and the frontal hairline remains.…”

Section: Discussionmentioning

confidence: 99%

Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study

Bi,

Wang,

et al. 2024

CCID

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To investigate whether increased levels of lipids-related metabolites (LRMs) result in androgenic alopecia (AGA). Patients and Methods: A two-sample Mendelian randomization (MR) study was designed, and single nucleotide polymorphisms (SNPs) respectively related to nine LRMs were selected from the genome-wide association study (GWAS) dataset. An MR analysis was performed to assess the causal association between LRMs and AGA. Results: Through the fixed-effect inverse variance weighting (IVW) method, MR analysis indicated that Apolipoprotein B (ApoB), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) had a causal relationship with AGA. No obvious heterogeneity or pleiotropy was observed. Conclusion:The risk of AGA increases significantly when the serum levels of ApoB, LDL, and VLDL increase. This causal relationship is solid and free of interference from confounding factors.

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Section: Discussionmentioning

confidence: 99%

Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study

Bi,

Wang,

et al. 2024

CCID

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“…This disorder is inherited from both parents and is polygenic, meaning that the degree to which it manifests in an individual might vary. Androgenetic alopecia runs in families; if a father has baldness, his sons are five to six times more likely to do so as well [3] .…”

Section: Introductionmentioning

confidence: 99%

Relation between Androgenic Alopecia with Metabolic Syndrome: Review Article

2024

The Egyptian Journal of Hospital Medicine

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Background: Androgenetic alopecia (AGA) is the most prevalent form of hair loss in men and women, characterized by a progressive thinning of hair influenced by androgens and genetic predisposition. Recent studies suggest a potential link between AGA and metabolic syndrome (MetS), a cluster of conditions that increase the risk for heart disease and other health problems. Understanding the association between AGA and MetS could lead to improved screening and management strategies, potentially mitigating cardiovascular risk in affected individuals. Objective: This review aimed to synthesize current knowledge on the pathophysiology, genetic basis, and treatment options for AGA, with a focus on the relationship between AGA and MetS. The objective was to highlight the importance of early detection and comprehensive management of AGA, considering its association with systemic health issues. Methods: A thorough literature review was conducted, analyzing studies from PubMed, Cochrane Library, and Google Scholar databases. Articles published up to April 2023 were included, with a focus on those providing insights into the pathophysiology of AGA, its treatment, and its association with MetS. Cross-sectional, cohort, and case-control studies were reviewed to assess the strength of the relationship between AGA and MetS. Conclusions: AGA is not only a cosmetic concern but also a potential marker for underlying metabolic dysregulation. The evidence suggested a strong association between AGA and MetS, emphasizing the role of androgens and genetic predisposition in both conditions. Early intervention in patients with AGA could serve as a preventive strategy for MetS and related cardiovascular diseases. Healthcare providers should consider screening for MetS components in patients presenting with AGA, particularly in those with a family history of metabolic or cardiovascular disorders.

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