Background-The impact of vascular closure devices (VCDs) via the femoral arterial access site on short-term mortality in patients undergoing percutaneous coronary intervention is currently unknown.
001).A more pronounced association of VCD with a reduction in 30-day mortality was evident in females (HR, 0.85; 95% CI, 0.77-0.94; P interaction =0.037), presentation with acute coronary syndrome (HR, 0.88; 95% CI, 0.83-0.94; P interaction =0.0027), or recent lysis (HR, 0.63; 95% CI, 0.40-1.01; P interaction =0.0001). Conclusions-When compared with manual pressure, VCD was associated with a minor short-term (30-day) prognostic benefit after propensity score correction in the global population and clinically relevant subgroups. The potential for residual confounding factors impacting on short-term mortality cannot be excluded, despite the study having measured and balanced all recorded confounder factors. (Circ Cardiovasc Interv. 2016;9:e003560.