Femoral bone defect healing using two novel biocompatible degradable materials

Abstract

<jats:p>This study was conducted as an <jats:italic>in vivo</jats:italic> experiment in adult miniature pigs with the aim to test two new biomaterials. An iatrogenic defect was made into the central femoral diaphysis in the experimental animals and subsequently fixated by bridging plate osteosynthesis. Into the defect we implanted a cancellous autograft (control group), a pasty injectable scaffold (EXP A), and a porous 3D cylinder (EXP B). Radiological examination was performed in all animals at 0, 10, 20, 30 weeks after surgical procedure and histological assessment was performed. In the newly formed bone the osteoblastic activity was monitored. In terms of radiology, the most effective method was observed in the control group (completely healed 100%) compared to experimental groups EXP A (70.0%) and EXP B (62.5%). Histological assessment showed a higher cell count in the place of bone defect in the control group compared to experimental groups. Between the experimental groups, a higher count of bone marrow cells was found in group EXP B. Both newly developed biomaterials seem to be suitable as replacements for large bone defects, having good workability and applicability. However, compared to the control group treated with a cancellous autograft, the newly formed bone did not reach the same number of cells settling in and in some cases, full radiological healing was not reached. Nevertheless, the material was found to be grown into the original bone in all cases within the experimental groups. The new biomaterials have a great potential as a substitute in the treatment of large bone defects.</jats:p>

Microcomputed tomographic, biomechanical and histological analyses of lumbar interbody fusion with iliac crest bone graft in a pig model

“…al. 2008;Planka et al 2012;Atesok et al 2017) is still ongoing but the focus if now on non-cellular materials (Srnec et al 2020). Such materials are less complicated to handle and safe to implant.…”

Mechanical Testing of Tendons Sutured with Newly Developed Biomaterial

“…Mezi mechanickou pevností sutury a mírou poškození šlachy suturou jsou velmi pevné vztahy (13). Na pracovišti autorů článku se kolektiv výzkumných pracovníků již několik let věnuje výzkumu v oblasti nových materiálů a taktéž mechanickým testováním náhrad vazů a šlach (5,6,7,15). Získané poznatky z těchto studií byly v této práci obohaceny a rozšířeny, zejména se zaměřením na vývoj nového vlákna vhodného pro sutury šlach.…”