Fendiline, an anti-anginal drug, increases intracellular Ca 2+ in PC3 human prostate cancer cells

Cr, Jan; Kc, Lee; Kj, Chou; Js, Cheng; Jl, Wang; Yk, Lo; Ht, Chang; Ky, Tang; Chao, Yu–Faye; Jk, Huang

doi:10.1007/s002800000262

Cited by 20 publications

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“…Studies on the association between antihypertensive drug usage and prostate cancer risk remain controversial. In vitro studies, CCB enhanced apoptosis of prostate cancer cells and might have a protective effect on prostate cancer [ 13 ]. Debes et al found that CCB significantly decreased the risk of prostate cancer, and their results varied by family history of prostate cancer [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies

et al. 2018

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BackgroundDue to the lack of strong evidence to identify the relationship between antihypertensive drugs use and the risk of prostate cancer, it was needed to do a systematic review to go into the subject.MethodsWe systematically searched PubMed, Web of Science and Embase to identify studies published, through May 2015. Two evaluators independently reviewed and selected articles involving the subject. We used the Newcastle-Ottawa Scale (NOS) to assess the quality of the studies. All extracted results to evaluate the relationship between antihypertensive drugs usage and prostate cancer risk were pool-analysed using Stata 12.0 software.ResultsA total of 12 cohort and 9 case-control studies were ultimately included in our review. Most of the studies were evaluated to be of high quality. There was no significant relationship between angiotensin converting enzyme inhibitors (ACEI) usage and the risk of prostate cancer (RR 1.07, 95% CI 0.96–1.20), according to the total pool-analysed. Use of angiotensin receptor blocker (ARB) was not associated with the risk of prostate cancer (RR 1.09, 95% CI 0.97–1.21), while use of CCB may well increase prostate cancer risk based on the total pool-analysed (RR 1.08, 95% CI 1–1.16). Moreover, subgroup analysis suggested that use of CCB clearly increased prostate cancer risk (RR 1.10, 95% CI 1.04–1.16) in terms of case-control studies. There was also no significant relationship between use of diuretic (RR 1.09, 95% CI 0.95–1.25) or antiadrenergic agents (RR 1.22, 95% CI 0.76–1.96) and prostate cancer risk.ConclusionsThere is no significant relationship between the use of antihypertensive drugs (ACEI, ARB, beta-blockers and diuretics) and prostate cancer risk, but CCB may well increase prostate cancer risk, according to existing observational studies.Electronic supplementary materialThe online version of this article (10.1186/s12894-018-0318-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies

et al. 2018

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α‐Aziridinyl Carbenium Ion Intermediate and Stereoselective Dehydroxylative Diarylation of Aziridin‐2‐yl Carboxaldehyde

et al. 2022

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α-Aziridinyl carbenium ion as an intermediate was observed for the first time from the reaction of aziridin-2-yl arylmethanol with Lewis acid BF 3 • OEt 2 . This intermediate was further reacted with various nucleophiles including electronrich arenes to afford the adducts in highly stereoselective manner as singly isomers. α-Aziridinyl carbenium ion intermediate was observed spectroscopically as a crucial intermediate, and density functional theory (DFT) calculations show the origin of stereoselectivity based on thermodynamic preference for the reaction.

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Imidazole-induced elevations of intracellular calcium in HL-60 cells: effect of inhibition of phospholipase C by the steroidal maleimide U73122

Daly¹,

Camerini-Otero²

2006

Drug Dev. Res.

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A variety of agents, including imidazoles, such as miconazole, elicit elevations of calcium in human leukemic HL-60 cells through a stimulation of influx of calcium and/or a release of intracellular calcium. Release of intracellular calcium by such agents may involve stimulation of IP 3 formation. The steroidal maleimide U73122, a potent phospholipase C (PLC) inhibitor, at 3-10 mM blocked elevations of calcium elicited in HL-60 cells by ATP. At a 10 mM concentration, U73122 either blocked or altered elevations of calcium elicited by imidazoles, such as miconazole, SKF 96365, and clotrimazole that are often used to block capacitative calcium entry, and by calmidazolium, a quaternary imidazole that can trigger massive influx of calcium in HL-60 cells. Elevations of calcium elicited by thapsigargin were not affected by 3 mM U73122, but were reduced by higher concentrations. Remarkably, U73122 at 10 mM did not block, but instead slowed and potentiated the elevation of calcium elicited by higher concentrations of imidazoles, an effect that may involve inhibition of Ca 21 -ATPases of the endoplasmic reticulum. The steroidal succinimide U73343 had minimal effects on calcium elevations in HL-60 cells. The results indicate that U73122 requires cautious use in assessing the role of PLC in controlling calcium levels in HL-60 cells, in particular when used with imidazoles, such as SKF 96365, which are used to block capacitative calcium entry. The effects of U73122 on cell calcium are reviewed. In toto, the results suggest that many lipophilic agents may affect intracellular calcium by activating PLC through unknown mechanisms. Drug Dev. Res.

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Fendiline, an anti-anginal drug, increases intracellular Ca 2+ in PC3 human prostate cancer cells

Abstract: The anti-anginal drug fendiline induced internal Ca2+ release and external Ca2+ entry. Because prolonged increases in [Ca2+]i may lead to cell injury and death, the long-term effect of fendiline on the function of prostate cancer cells should be investigated.

Cited by 20 publications

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Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies

Antihypertensive drugs use and the risk of prostate cancer: a meta-analysis of 21 observational studies

α‐Aziridinyl Carbenium Ion Intermediate and Stereoselective Dehydroxylative Diarylation of Aziridin‐2‐yl Carboxaldehyde

Imidazole-induced elevations of intracellular calcium in HL-60 cells: effect of inhibition of phospholipase C by the steroidal maleimide U73122

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