Fenugreek Seed Powder Nullified Aluminium Chloride Induced Memory Loss, Biochemical Changes, Aβ Burden and Apoptosis via Regulating Akt/GSK3β Signaling Pathway

Abstract

Alzheimer's disease (AD) is the most common form of dementia that mainly affects the cognitive functions of the aged populations. Trigonella foenum-graecum (L.) (fenugreek), a traditionally well utilized medicinal plant ubiquitously used as one of the main food additive worldwide, is known to have numerous beneficial health effects. Fenugreek seed extract could be able to inhibit the activity of acetylcholinesterase (AChE), a key enzyme involved in the pathogenesis of AD, and further shown to have anti-parkinsonic effect. The present study was aimed to explore the neuroprotective effect of fenugreek seed powder (FSP) against aluminium chloride (AlCl3) induced experimental AD model. Administration of germinated FSP (2.5, 5 and 10% mixed with ground standard rat feed) protected AlCl3 induced memory and learning impairments, Al overload, AChE hyperactivity, amyloid β (Aβ) burden and apoptosis via activating Akt/GSK3β pathway. Our present data could confirm the neuroprotective effect of fenugreek seeds. Further these results could lead a possible therapeutics for the management of neurodegenerative diseases including AD in future.

HPLC-PDA-MS/MS profiling of secondary metabolites from Opuntia ficus-indica cladode, peel and fruit pulp extracts and their antioxidant, neuroprotective effect in rats with aluminum chloride induced neurotoxicity

“…After 24 h the rat was placed in the light chamber again and the time taken to enter the dark chamber was recorded as step-through latency. If the animal did not enter the dark chamber within a 3-min test period, the test was terminated and the step-through latency was noted as 180 sec ( Prema et al, 2016 ).…”

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer rsquo s disease

“…After 24 h, each and every rat was placed individually again in the light chamber and the time taken by them to enter into the dark chamber was considered as step-through latency. If the rat did not enter the dark chamber within a 5-minute test period, the test was ceased and the step-through latency was noted as 300 seconds (23).…”

Histomorphological evaluations on the frontal cortex extrapyramidal cell layer following administration of N-Acetyl cysteine in aluminum induced neurodegeneration rat model

“…Alzheimer's disease [AD]) are associated with chronic inflammation, oxidative stress (Mayeux 2010;Ahmad et al 2018), progressive cognitive deficits and changes in neuro-behavioural pattern (Jellinger 2013). AD is linked with memory deficit and tau protein (Prema et al 2017). There is need for new drug discovery to combat this menace as it is reported that 75% of the thirty-six million people worldwide affected with dementia are estimated to be AD patient, and it is predicated that 1 in 85 people will be affected by 2050 (Bhattacharya et al 2014).…”