Fenugreek (Trigonella foenum-graecum): Nutraceutical values, phytochemical, ethnomedicinal and pharmacological overview

Ruwali, Pushpa; Pandey, Niharika; Jindal, Khusboo; Singh, Rahul Vikram

doi:10.1016/j.sajb.2022.04.014

Cited by 24 publications

(11 citation statements)

References 63 publications

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“…The emerging source of diosgenin in fenugreek ( Trigonella foenum graecum L.) which belongs to Leguminosae and serve as an annual medicinal plant for ages (Irankhah et al, 2021). Fenugreek seeds are enriched with alkaloids, proteins, mucilage (Wani & Kumar, 2016), oil (Munshi et al, 2020), and control hyperglycemia in diabetic patients (Ruwali et al, 2022). The medicinal properties of fenugreek are majorly linked to its various bioactive compounds such as diosgenin, yamogenin, apigenin (Arya & Kumar, 2022), and 4‐hydroxyleucine (Kiss et al, 2019).…”

Section: Diosgeninmentioning

confidence: 99%

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Arya

Kumar

2022

Journal of Food Biochemistry

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The consumption and composition of food in daily life predict our health in long run. The relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin regulation in the human body by damaging pancreatic β cells. Diabetes has a strong potential towards altering cellular mechanisms of organs causing unlawful performance. Diabetes alters pathways like TLR4, AChE, NF‐ĸB, LPL, and PPAR at different sites that affect the normal cellular machinery and cause damage to the local tissue and organ. The long‐lasting effect of diabetes was observed in vascular, cardia, nervous, skeletal, reproductive, hepatic, ocular, and renal systems. The increasing awareness of diabetes and its concern has awakened the common people more enthusiastically. Due to rising harm from diabetes, scientific researchers tend to have more eyes toward it. While searching for diabetes solutions, fenugreek diosgenin could pop up with some positive effects in curing the same. Diosgenin helps to lower the scathe of diabetes by modifying cellular pathways in favor of healthy bodily functions. Diosgenin altered the pathways for renewal of pancreatic β cells for better insulin secretion, initiate GLUT4, enhanced DHEA, modify ER‐α‐mediated PI3K/Akt pathways. Diosgenin can be an appropriate insult for diabetes in a much evolving way for a healthy lifestyle. Practical applications Diabetes is one of the most death causing diseases in the medical world. Regrettably the cure of diabetes is yet to be found. Various scientific team working on the same to look after the most appropriate way for diabetes treatment. There is enormous growth of nutraceutical in the market claiming for cure of different metabolic disorders. Among various bioactive compound fenugreek's diosgenin could took a leap over other in curing and preventing the damage caused by diabetes to different organs. The role of diosgenin in curing various metabolic disorders is quite popular from some time. This article also emphasizes over beneficiary effect of diosgenin in curing the damages caused by diabetes by altering cellular metabolism processes. Hence diosgenin could be a better way for researchers to develop a method for diabetes treatment.

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Section: Diosgeninmentioning

confidence: 99%

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Arya

Kumar

2022

Journal of Food Biochemistry

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“…Being an easily available herbal agent and due to its promising benefits in treating diabetes and obesity, fenugreek is used by a great number of people across the globe 41 , 42 . Therefore, it is suggested that fenugreek should be evaluated for its adverse effect profile and drug–drug and drug–food interactions so that people may get more benefits from these traditional plants.…”

Section: Discussionmentioning

confidence: 99%

Enhancing glycaemic control and promoting cardiovascular health: the therapeutic potential of Trigonella foenumgraecum in diabetic patients – a systematic review and meta-analysis

Shakil,

Akhtar,

Ali

et al. 2024

Annals of Medicine &Amp; Surgery

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Background: The antidiabetic potential of fenugreek has been highlighted in past literature, and various in vitro and in vivo studies have validated its glucose-lowering effects; however, very limited data is available on its effects on diabetic patients. Objective: An updated systematic review and meta-analysis of randomised control trials, that assessed patients who were administered Fenugreek. Methods: The PRISMA guidelines, Supplemental Digital Content 1, http://links.lww.com/MS9/A361 were followed when conducting this meta-analysis. PubMed, Scopus, Google Scholar, and MEDLINE were searched from inception until June 2023, for randomised control trials that compared Fenugreek with control in patients with type 2 diabetes mellites and reported the following outcomes of interest; Fasting Blood Glucose, HbA1c and post-prandial glucose levels. The findings were presented as mean difference (MD) with 95% confidence intervals (CIs) and were pooled using a random effects model. Results: Fenugreek significantly (P<0.001) reduced the Fasting Blood Sugar (FBS), HbA1c levels and post-prandial glucose levels in diabetic patients when compared to the control. Conclusion: Among patients with Type 2 DM, our comparisons demonstrated a reduction of Fasting Blood Sugar (FBS), HbA1c levels and post-prandial glucose levels with the administration of Fenugreek seed at 2-5mg dose in powder form.

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“…The name of this plant comes from the Greek word trigonou meaning triangle, because of the triangular shape of its leaflets. therapeutic competency, and it also lowers hyperglycemia in diabetic patients [10].…”

Section: Morphologymentioning

confidence: 98%

A therapeutic approach of trigonella foenum graceum – a brief overview

M¹,

Meera²,

Nikitha³

et al. 2022

J Integral Sci

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Trigonella foenum graceum has a place in the fabaceae family fenugreek. It is composed of a variety of alkaloids, saponins, flavonoids, free fatty acids and lipids, vitamins, minerals mucilage and fibres. Trigonella foenum graceum have hepatoprotective activity, antioxidant activity, mast cell stabilizing activity, anticancer activity, antibacterial activity, cardioprotective effect and antigenotoxic activity. Traditional medicine in India and other parts of the globe has used Trigonella foenum graceum as carminative, lactation stimulant, laxative, antidiabetic effect, hypocholesterolemic influence, antioxidant potency, digestive stimulant action and hepatoprotective effect.

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Fenugreek (Trigonella foenum-graecum): Nutraceutical values, phytochemical, ethnomedicinal and pharmacological overview

Cited by 24 publications

References 63 publications

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Diosgenin: An ingress towards solving puzzle for diabetes treatment

Enhancing glycaemic control and promoting cardiovascular health: the therapeutic potential of Trigonella foenumgraecum in diabetic patients – a systematic review and meta-analysis

A therapeutic approach of trigonella foenum graceum – a brief overview

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