Fermentation, a feasible strategy for enhancing bioactivity of herbal medicines

Hussain, Ahtesham; Bose, Shambhunath; Wang, Jing-Hua; Yadav, Mukesh; Mahajan, Girish; Kim, Hojun

doi:10.1016/j.foodres.2015.12.026

Cited by 156 publications

(110 citation statements)

References 145 publications

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“…As discussed above, this observation may be explained by the increase in the low molecular compounds and by the conversion of existing anthocyanins by fermentation into the aglycone forms (Hussain et al, 2016). Thus demonstrating that higher antioxidant potential can occur even at low temperatures (4ºC) (Otieno et al, 2005, Moraes Filho et al, 2014.…”

Section: Storage Stabilitymentioning

confidence: 91%

Juçara (Euterpe edulis) pulp as a substrate for probiotic bacteria fermentation: Optimisation process and antioxidant activity

Guergoletto

2018

Emir J Food Agric

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Juçara fruit (Euterpe edulis) has received considerable attention because of its high content of phenolic compounds. However, its suitability as a matrix for probiotic bacteria is not known yet. The objective of this study was to evaluate the pH and temperature conditions for the fermentation in juçara pulp by Lactobacillus reuteri and Lactobacillus plantarum. The optimised conditions were determined by central composite rotational design, and used for the analysis of cellular viability, sugar content, pH, lactic acid, total phenolics and antioxidant activity during 80 h of fermentation. The conditions for probiotic growth were 32 °C with a pH of 5.7 for L. reuteri and 25 °C with a pH of 5.0 for L. plantarum, and 30 h of fermentation time for both bacteria. The viabilities remained above 8.6 ± 0.2 log colony forming units (cfu)/mL, and at 536.7 mg gallic acid equivalent (GAE)/100 mL of total phenolic reached. L. reuteri consumed all of the glucose and fructose present in juçara, whereas L. plantarum used only glucose. After 28 days of refrigerated storage, the cell viability of probiotics remained at 8.7 log CFU/mL with an increase in the antioxidant activity. Juçara pulp can be effective for a probiotic growth substrate and the production of new functional beverage.

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Section: Storage Stabilitymentioning

confidence: 91%

Juçara (Euterpe edulis) pulp as a substrate for probiotic bacteria fermentation: Optimisation process and antioxidant activity

Guergoletto

2018

Emir J Food Agric

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“…The reasons may include the nature of the diseases, natural evolution of feedback loops and pathway redundancy. Traditional Chinese herbal medicines are rich in numerous bioactive substances with several biological properties, including anti‐inflammatory, anti‐infection and immunoregulatory properties . Traditional Chinese herbal medicine has been demonstrated to be effective for treating NAFLD .…”

Section: Introductionmentioning

confidence: 99%

“…Traditional Chinese herbal medicines are rich in numerous bioactive substances with several biological properties, including anti-inflammatory, anti-infection and immunoregulatory properties. 6 Traditional…”

Section: Introductionmentioning

confidence: 99%

Effects and therapeutic mechanism of Yinzhihuang on steatohepatitis in rats induced by a high‐fat, high‐cholesterol diet

Zeng

Liu

Xin

et al. 2020

J of Digest Diseases

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Objectives We aimed to investigate the therapeutic mechanism of Yinzhihuang (YZH) liquid, a traditional Chinese medicine mainly composed of extracts of four components, on nonalcoholic steatohepatitis (NASH) induced by a high‐fat, high‐cholesterol diet (HFHCD) in rats. Methods Altogether 30 Sprague‐Dawley rats were randomized into three groups: control, the model group (HFHCD + saline) and the treatment group (HFHCD + YZH). Liver histological features and serum biochemical parameters were assessed by the end of the 16th week. RNA sequencing and protein mass spectrometry detection were performed. The genes and proteins expressed differentially were subjected to KEGG pathway enrichment analysis and included in a network‐based regulatory model. Results The weight, liver and fat indices and serum alanine transaminase, aspartate transaminase and total cholesterol levels of the HFHCD + YZH group were all significantly lower than those of the HFHCD + saline group. Moreover, their hepatic steatosis, ballooning and lobular inflammation were relieved, and 64 hepatic genes and 73 hepatic proteins were found to be reversed in their expression patterns after YZH treatment (P < 0.05). The network‐based regulatory model showed that these deregulated genes and proteins were mainly involved in oxidative phosphorylation, Toll‐like receptor, nucleotide‐binding oligomerization domain‐like receptor, peroxisome proliferator‐activated receptor signaling, nuclear factor‐kappa B tumor necrosis factor signaling pathways and fatty acid metabolism. Conclusion YZH could alleviate NASH in HFHCD‐fed rats by inhibiting lipogenesis, accelerating lipid β‐oxidation, alleviating oxidative stress and relieving necroinflammation in the liver.

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“…In addition, LAB may provide probiotic compounds [4,5]. Consequently, lactofermentation of medicinal plants is a worthwhile process to obtain extracts forgoing the use of organic solvents [6]. In such fermented extracts, genuine plant metabolites are either still intact, or are partially or completely converted into other constituents [7].…”

Section: Introductionmentioning

confidence: 99%

Conversion of Plant Secondary Metabolites upon Fermentation of Mercurialis perennis L. Extracts with two Lactobacteria Strains

et al. 2019

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Microbial fermentation of plant extracts with Lactobacteria is an option to obtain microbiologically stable preparations, which may be applied in complementary medicine. We investigated the metabolic conversion of constituents from Mercurialis perennis L. extracts, which were prepared for such applications. For this purpose, aqueous extracts were inoculated with two Lactobacteria strains, namely Pediococcus sp. (PP1) and Lactobacillus sp. (LP1). Both were isolated from a fermented M. perennis extract and identified by 16S rRNA sequencing. After 1 day of fermentation, an almost complete conversion of the genuine piperidine-2,6-dione alkaloids hermidine quinone (3) and chrysohermidin (4)—both of them being oxidation products of hermidin (1) —was observed by GC-MS analysis, while novel metabolites such as methylhermidin (6) and methylhermidin quinone (7) were formed. Surprisingly, a novel compound plicatanin B (bis-(3-methoxy-1N-methylmaleimide); 8) was detected after 6 days, obviously being formed by ring contraction of 4. An intermediate of a postulated reaction mechanism, isochrysohermidinic acid (14), could be detected by LC-MS. Furthermore, an increase in contents of the metabolite mequinol (4-methoxyphenol; 9) upon fermentation points to a precursor glycoside of 9, which could be subsequently detected by GC-MS after silylation and identified as methylarbutin (15). 15 is described here for M. perennis for the first time.

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Fermentation, a feasible strategy for enhancing bioactivity of herbal medicines

Cited by 156 publications

References 145 publications

Juçara (Euterpe edulis) pulp as a substrate for probiotic bacteria fermentation: Optimisation process and antioxidant activity

Juçara (Euterpe edulis) pulp as a substrate for probiotic bacteria fermentation: Optimisation process and antioxidant activity

Effects and therapeutic mechanism of Yinzhihuang on steatohepatitis in rats induced by a high‐fat, high‐cholesterol diet

Conversion of Plant Secondary Metabolites upon Fermentation of Mercurialis perennis L. Extracts with two Lactobacteria Strains

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