Fermented<i>Platycodon grandiflorum</i>Extracts Relieve Airway Inflammation and Cough Reflex Sensitivity<i>In Vivo</i>

Lee, So‐Yeon; Han, Eun Hye; Lim, Mi Kyung; Lee, Sang Ho; Yu, Heui Jong; Lim, Young Hee; Kang, Seongman

doi:10.1089/jmf.2019.4595

Cited by 38 publications

(27 citation statements)

References 38 publications

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“…Likewise, Platycodon grandiflorum extracts might not be notable in reducing DPPH and ABTS radicals, but they could lower pro‐inflammatory cytokines in LPS‐induced RAW 264.7 macrophage cells (Kim et al ., 2020). Moreover, P. grandiflorum showed a great alleviation of the citric acid‐stimulated cough reflex in guinea pigs as an effective reliever in airway inflammation (Lee et al ., 2020). It can be seen that this mushroom was used as superfood for the emperor of China for more than 100 years as a longevity food for the anti‐ageing and anti‐inflammatory effects (Dai et al ., 2009).…”

Section: Resultsmentioning

confidence: 99%

Anti‐inflammation of bioactive compounds from ethanolic extracts of edible bamboo mushroom (Dictyophora indusiata) as functional health promoting food ingredients

Ruksiriwanich

Khantham

Linsaenkart

et al. 2021

Int J of Food Sci Tech

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The edible bamboo mushroom Dictyophora indusiata, which is rich in food nutrients and has medicinal values, has been investigated for nutrition compositional analysis. Then, three parts (whole mushroom: WE; peel and green mixture: PGE; and core: CE) were determined for antioxidant, MMP-2 inhibition, and anti-inflammatory properties. WE depicted the highest bioactive contents among others. The CE and WE with non-cytotoxic effect on fibroblasts gave high MMP-2 inhibitory activity (44.93% and 30.32%, respectively), compared with L-ascorbic acid (50.65%). For the anti-inflammatory activity, all D. indusiata extracts significantly inhibited the nitric oxide (NO), interleukin (IL)-1β, IL-6, and tumour necrosis factor (TNF)-α secretion compared with the LPS treatment in all-time intervals (P < 0.05). Moreover, WE extract containing various bioactive compounds (polyphenolic, monosaccharide, mucopolysaccharide, allantoin, and alkaloid contents) showed similar anti-inflammatory activity to the standard diclofenac. It can be concluded that WE could be served as functional food ingredients and potential to be healthpromoting products.

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Section: Resultsmentioning

confidence: 99%

Anti‐inflammation of bioactive compounds from ethanolic extracts of edible bamboo mushroom (Dictyophora indusiata) as functional health promoting food ingredients

Ruksiriwanich

Khantham

Linsaenkart

et al. 2021

Int J of Food Sci Tech

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“…Platycoside E and platycodin D 3 are precursors of platycodin D with the conversion occurring under β-D-glucosidase hydrolysis, and the three components above belong to one synthetic pathway. Studies have recently focused on the genome level [32]; Previously, research on genes involved in platycodin biosynthesis was carried out based on RNA-seq.…”

Section: Discussionmentioning

confidence: 99%

SMRT- and Illumina‑based RNA‑seq Analyses Unveil Triterpenoid Saponin Biosynthesis and Related Key Genes in Platycodon Grandiflorus (Jacq.) A. DC.

Liu

Yin

et al. 2021

Preprint

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Background: Platycodon grandiflorus, a traditional Chinese medicine, contains considerable triterpene saponins with broad pharmacological activities. To date, information on the molecular mechanism of triterpenoid saponin biosynthesis in P. grandiflorus is limited. Here, single-molecule real-time (SMRT) and next-generation sequencing technologies were combined to comprehensively analyse the transcriptome and unveil triterpenoid saponin biosynthesis in P. grandiflorus.Results: We quantified four saponin monomers in P. grandiflorus, and found that the total content of the four saponins was the highest in the roots and the lowest in the stems and leaves. A total of 173,354 non-redundant transcripts generated from the PacBio platform were successfully annotated to seven functional databases, among which 1,765 transcripts were aligned to the "metabolism of terpenoids and polyketides" pathway in the KEGG database. Three full-length transcripts of β-amyrin synthase (β-AS), the key synthase of the β-amyrin, were identified. Furthermore, a total of 132,610 clean reads of BGISEQ sequences were utilised to explore key genes related to the triterpenoid saponin biosynthetic pathway in P. grandiflorus, and 96 differentially expressed genes (DEGs) involved were selected as candidates. Notably, 9 of the 96 DEGs showed the highest expression in the roots, which were considered key genes for synthesising triterpenoid saponins in P. grandiflorus. Furthermore, 3,469 genes encoding transcription factors (TFs) were identified and classified into 57 TF families, including MYB, bHLH, mTERF, and AP2-EREBP. The expression levels of genes were verified by quantitative real-time PCR.Conclusions: Our reliable transcriptome data provide valuable information on the related biosynthesis pathway and may provide new insights into the molecular mechanisms of triterpenoid saponin biosynthesis in P. grandiflorus.

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“…29 Evidence showed that dietary GP possessed benecial effects on different diseases and symptoms, such as coronary heart disease, inammation and cancer, and apparently without serious side effects. 30 For GP, phosphatidic acid (PA, 19), PC (18), PE (18), phosphatidylinositol (PI, 9), LPE (7), LPC (6), phosphatidylmethanol (PMeOH, 6), lysophosphatidic acid (LPA, 5), phosphatidylglycerol (PG, 3), lysophosphatidylinositol (LPI, 2) and phosphatidylserine (PS, 2) were identied.…”

Section: Lipidome Proling Of Platycodonis Radixmentioning

confidence: 99%

“…4,5 Previous studies have shown that Platycodonis radix exhibits various pharmacological properties such as apophlegmatic, anti-inammatory, anti-cancer, anti-obesity, anti-diabetic, immunomodulatory, cardiovascular protective and hepatoprotective activities. [5][6][7][8] With its increasing consumption, cultivated Platycodonis radix has become an alternative to the wild variety over the years. At present, the output in a normal year in China is 1 million kg, of which export accounts for half.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive profiling of Platycodonis radix in different growing regions using liquid chromatography coupled with mass spectrometry: from metabolome and lipidome aspects

et al. 2022

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FermentedPlatycodon grandiflorumExtracts Relieve Airway Inflammation and Cough Reflex SensitivityIn Vivo

Cited by 38 publications

References 38 publications

Anti‐inflammation of bioactive compounds from ethanolic extracts of edible bamboo mushroom (Dictyophora indusiata) as functional health promoting food ingredients

Anti‐inflammation of bioactive compounds from ethanolic extracts of edible bamboo mushroom (Dictyophora indusiata) as functional health promoting food ingredients

SMRT- and Illumina‑based RNA‑seq Analyses Unveil Triterpenoid Saponin Biosynthesis and Related Key Genes in Platycodon Grandiflorus (Jacq.) A. DC.

Comprehensive profiling of Platycodonis radix in different growing regions using liquid chromatography coupled with mass spectrometry: from metabolome and lipidome aspects

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