Fermented Milk Consumption and Common Infections in Children Attending Day‐Care Centers

Продеус, А.П.; Niborski, Violeta; Schrezenmeir, J.; Gorelov, Alexander; Shcherbina, Anna; Rumyantsev, A.G.

doi:10.1097/mpg.0000000000001248

Cited by 18 publications

(35 citation statements)

References 56 publications

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“…Only Bacteroides, Roseburia, and Blautia oligotype patterns were significantly affected by treatment. After the initial round of oligotyping, high-entropy positions were chosen (-C option): 2, 27, 30, 31, 32, 94, 114, 120, and 291 (Bacteroides); 1,2,12,27,28,30,56,57,58,61,82,101,103,157,160,170,172,174,176,184,191,213,215,220,235,237,273,274,293,343,347,371, and 409 (Blautia); and 2, 28, 57, 215, 272, 369, 370, 409, and 410 (Roseburia). To minimize the impact of sequencing errors, we required an oligotype to be represented by at least 100 reads (-M option).…”

Section: Methodsmentioning

confidence: 99%

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Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74

Canani

Filippis

Nocerino

et al. 2017

Appl Environ Microbiol

108

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We recently demonstrated that cow's milk fermented with the probiotic CBA L74 (FM-CBAL74) reduces the incidence of respiratory and gastrointestinal tract infections in young children attending school. This effect apparently derives from a complex regulation of non-immune and immune protective mechanisms. We investigated whether FM-CBAL74 could regulate gut microbiota composition and butyrate production. We randomly selected 20 healthy children (12 to 48 months) from the previous randomized controlled trial, before (t0) and after 3 months (t3) of dietary treatment with FM-CBAL74 (FM) or placebo (PL). Fecal microbiota was profiled using 16S rRNA gene amplicon sequencing, and the fecal butyrate concentration was also measured. Microbial alpha and beta diversities were not significantly different between groups prior to treatment. FM-CBAL74 but not PL treatment increased the relative abundance of Individual ,, and oligotypes were associated with FM-CBAL74 treatment and demonstrated correlative associations with immune biomarkers. Accordingly, PICRUSt analysis predicted an increase in the proportion of genes involved in butyrate production pathways, consistent with an increase in fecal butyrate observed only in the FM group. Dietary supplementation with FM-CBAL74 induces specific signatures in gut microbiota composition and stimulates butyrate production. These effects are associated with changes in innate and acquired immunity. The use of a fermented milk product containing the heat-killed probiotic strain CBAL74 induces changes in the gut microbiota, promoting the development of butyrate producers. These changes in the gut microbiota composition correlate with increased levels of innate and acquired immunity biomarkers.

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Section: Methodsmentioning

confidence: 99%

“…the gut microbiota (2). Functional foods, based on the fermentation of cow's milk with probiotics, have been proposed as an effective strategy to reduce the incidence of infectious diseases in children, but the results are still conflicting (3)(4)(5)(6)(7)(8).…”

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confidence: 99%

Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74

Canani

Filippis

Nocerino

et al. 2017

Appl Environ Microbiol

108

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“…Moreover, L. paracasei CNCM I-1518, modulated the activity of Faecalibacterium prausnitzii in an in vitro gut model 20 . This strain was extensively studied in clinical trials, in the form of a fermented milk product that had beneficial effects on the incidence and duration of common respiratory and gastrointestinal infections, immunomodulation and antibiotic-associated-diarrhea, and this product was well-tolerated in various populations, including children, adults and the elderly [21][22][23][24][25][26][27] . The consumption of the product containing L. paracasei CNCM I-1518 and CNCM I-3689 and L. rhamnosus, CNCM I-3690 strains decreased Citrobacter rodentium-induced colonic crypt hyperplasia and prevented the loss of some bacterial genera in mice 28 .…”

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confidence: 99%

Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial

Alvarez¹,

Tap²,

Chambaud³

et al. 2020

Sci Rep

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Many clinical studies have evaluated the effect of probiotics, but only a few have assessed their dose effects on gut microbiota and host. We conducted a randomized, double-blind, controlled intervention clinical trial to assess the safety (primary endpoint) of and gut microbiota response (secondary endpoint) to the daily ingestion for 4 weeks of two doses (1 or 3 bottles/day) of a fermented milk product (Test) in 96 healthy adults. The Test product is a multi-strain fermented milk product, combining yogurt strains and probiotic candidate strains Lactobacillus paracasei subsp. paracasei CNCM I-1518 and CNCM I-3689 and Lactobacillus rhamnosus CNCM I-3690. We assessed the safety of the Test product on the following parameters: adverse events, vital signs, hematological and metabolic profile, hepatic, kidney or thyroid function, inflammatory markers, bowel habits and digestive symptoms. We explored the longitudinal gut microbiota response to product consumption and dose, by 16S rRNA gene sequencing and functional contribution by shotgun metagenomics. Safety results did not show any significant difference between the Test and Control products whatever the parameters assessed, at the two doses ingested daily over a 4-week-period. Probiotic candidate strains were detected only during consumption period, and at a significantly higher level for the three strains in subjects who consumed 3 products bottles/day. The global structure of the gut microbiota as assessed by alpha and beta-diversity, was not altered by consumption of the product for four weeks. A zero-inflated beta regression model with random effects (ZIBR) identified a few bacterial genera with differential responses to test product consumption dose compared to control. Shotgun metagenomics analysis revealed a functional contribution to the gut microbiome of probiotic candidates.

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“…The beneficial manipulation of the composition and metabolic footprint of the gut microbiota can be achieved by using probiotics. These can be defined as a preparation of, or a product containing, viable microorganisms in an adequate number to enable such dietary preparations to favourably modulate the gut microbiota . The ability to exert a beneficial modulation on the gut microbiota may be enhanced by combining probiotics with other ingredients (64), namely prebiotics, which are capable of favouring the growth and/or activity of microorganisms.…”

Section: Resultsmentioning

confidence: 99%

Paediatricians play a key role in preventing early harmful events that could permanently influence the development of the gut microbiota in childhood

et al. 2019

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Aim: The development of the gut microbiota occurs primarily during infancy, and growing evidence has emphasised its positive role and implications for human health. The aim of this review was to provide essential knowledge about the gut microbiota and to describe and highlight the importance of the factors that influence the gut microbiota in early life and their potential harmful effects later in life.

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Fermented Milk Consumption and Common Infections in Children Attending Day‐Care Centers

Abstract: Supplemental Digital Content is available in the text

Cited by 18 publications

References 56 publications

Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74

Specific Signatures of the Gut Microbiota and Increased Levels of Butyrate in Children Treated with Fermented Cow's Milk Containing Heat-Killed Lactobacillus paracasei CBA L74

Safety and functional enrichment of gut microbiome in healthy subjects consuming a multi-strain fermented milk product: a randomised controlled trial

Paediatricians play a key role in preventing early harmful events that could permanently influence the development of the gut microbiota in childhood

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