Fermenter Design

Karthikeyan, Akash; Joseph, Abey; Subramanian, Raghuraman; Nair, Baiju G.

doi:10.1007/978-981-16-5214-1_5

Cited by 3 publications

(2 citation statements)

References 84 publications

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“…For example, research about using its inhibitory ability against human papillomavirus in producing carrageenan-derived sexual lubricants and infant feeding formulas. [54] Among these properties, one noteworthy ability of carrageenan is its efficacy against cancer. Besides medical use, red seaweeds are viewed to enhance human resistance to tumor progression as a kind of food, which might be because of their antioxidant activity.…”

Section: 41carrageenan and Fucoidanmentioning

confidence: 99%

A review of several anticancer chemicals derived from natural medicinal plant

Dong

2024

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Humans have used natural plants and plant-derived medicines to cure various diseases for thousands of years. Of all the diseases that humans are facing, cancer is one of the most destructive ones. Scientists have studied anticancer chemicals from natural plants for decades, and some chemicals show significant effects against cancer and are applied widely in clinical use. Vinca alkaloids are a type of chemical derived from Catharanthus roseus. Members of the vinca alkaloids have been used in many chemotherapy regimens. Taxol is one of the most famous plant-derived medicines against cancer. Scientists have focused more than twenty years on improving its synthesis route. Solanine comes from plants in the genus Solanum. This kind of plant is used in TCM for cancer treatment. Apart from these land plants, marine plants and marine photosynthetic algae are also sources of antitumor agents. Carrageenan and Fucoidan are two examples of antitumor-active compounds derived from seagrass. They have both cytotoxicity and adjuvant ability. In the future, there will be more research on the improvement of the synthetic route of existing herbal compounds, the discovery of new herbal compounds, and the better utilization and combination of herbal compounds, and finally lead to better application of natural plant medicine against cancer.

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Section: 41carrageenan and Fucoidanmentioning

confidence: 99%

A review of several anticancer chemicals derived from natural medicinal plant

Dong

2024

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“…Marine microbes including bacteria, fungi, and unicellular algae, have attracted attention due to their huge diversity in form and generation of bioactive compounds bearing pharmacological significance [1]. Marine macrolides are unique in terms of their structural complexity, wide pharmacological characteristics by utilizing distinctive modes of actions [2,3].…”

Section: Introductionmentioning

confidence: 99%

Marine Macrolides: An Indepth Survey of Potential Therapeutic Activities

2024

JMSR

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Marine macrolides have a broad variety of biological activities, and this editorial explores those activities, as well as their potential effects on human health. There is an abundance of potential therapeutic agents to be discovered in the vast and enigmatic area of Earth's oceans. The extensive biodiversity and distinctive chemical compositions of marine animals have always captivated scientists, presenting a valuable reservoir of chemicals that hold promise for medicinal purposes. Within the broad category of chemicals, marine macrolides have attracted significant attention due to their wide range of biological activity and considerable potential for pharmacological use.

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Application of computational fluid dynamics for simulation of stirred bioreactors in Ansys Fluent

Bondarenko,

Guseva,

Safarov

2023

Vestn. Voronež. gos. univ. inž. tehnol.

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Stirred bioreactors are widely used in the pharmaceutical industry to produce various active substances for the treatment of cancer, heart and vascular diseases, viral and bacterial infections. Despite the widespread use of bioreactors with a stirrer, the optimization of mixing conditions remains an urgent task. In bioreactors of this type, continuous mixing of cells in a medium with a high rotation speed should be carried out. The manuscript considers an example of the use of computational fluid dynamics to study and model the process of cultivation Escherichia coli bacterial cells in a batch bioreactor (NLF, 30 l.). Computational fluid dynamics was used to analyze the hydrodynamic conditions in a bioreactor with a double Rushton turbine stirrer. To describe the movement of flows and evaluate turbulence in a batch bioreactor, the multiphase Euler model and the k-𝜀 turbulence model, respectively, were used, the built-in Ansys Fluent software package. A geometric model was built with the original dimensions of the bioreactor with an NLF 30 stirrer. Based on the geometric model, a computational grid was created for the working volume of the bioreactor and the optimal parameters for constructing the computational grid were selected. As a result of modeling the hydrodynamic regime, the distribution profiles of the turbulence kinetic energy over the volume of the bioreactor were obtained and the velocities of cell movement were found at different speeds of rotation of the stirrer. The obtained results show the possibility and applicability of the Ansys Fluent software package for calculating the hydrodynamic situation in a bioreactor with a stirrer at different stirring rates and at different cell volume fractions.

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Fermenter Design

Cited by 3 publications

References 84 publications

A review of several anticancer chemicals derived from natural medicinal plant

A review of several anticancer chemicals derived from natural medicinal plant

Marine Macrolides: An Indepth Survey of Potential Therapeutic Activities

Application of computational fluid dynamics for simulation of stirred bioreactors in Ansys Fluent

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