Ferrimagnetic Large Single Domain Iron Oxide Nanoparticles for Hyperthermia Applications

Abstract

This paper describes the preparation and obtained magnetic properties of large single domain iron oxide nanoparticles. Such ferrimagnetic particles are particularly interesting for diagnostic and therapeutic applications in medicine or (bio)technology. The particles were prepared by a modified oxidation method of non-magnetic precursors following the green rust synthesis and characterized regarding their structural and magnetic properties. For increasing preparation temperatures (5 to 85 °C), an increasing particle size in the range of 30 to 60 nm is observed. Magnetic measurements confirm a single domain ferrimagnetic behavior with a mean saturation magnetization of ca. 90 Am2/kg and a size-dependent coercivity in the range of 6 to 15 kA/m. The samples show a specific absorption rate (SAR) of up to 600 W/g, which is promising for magnetic hyperthermia application. For particle preparation temperatures above 45 °C, a non-magnetic impurity phase occurs besides the magnetic iron oxides that results in a reduced net saturation magnetization.

Polyetherimide‐ and folic acid‐modifiedFe3O4nanospheres for enhanced magnetic hyperthermia performance

“…Mahdi et al reported that GO/SPION, GO/SPION@PEG and GO‐ SPION@CS with SAR values of 305, 283 and 199 W/g, show superb anticancer performance. In our work, the SAR values are in good agreement with the results presented in literature 66,67 . Therefore, these results provide magnetic hyperthermia an effective approach for the treatment of clinical gynecological cancer in the future.…”

“…In our work, the SAR values are in good agreement with the results presented in literature. 66,67 Therefore, these results provide magnetic hyperthermia an effective approach for the treatment of clinical gynecological cancer in the future. Moreover, it is significant to evaluate the cytotoxicity of Fe 3 O 4 nanospheres prior to evaluating their biocompatibility for clinical applications.…”

Nanomaterials in Bone Regeneration

“…The magnetic properties of these particles can be used for optimal drug delivery to the required site, which minimizes side effects and improves the treatment of cancer and bone diseases. Fe-NPs and scaffolds containing these magnetic particles are used successfully in regenerative medicine, especially in bone tissue engineering and bone regeneration, because the magnetic field and magnetic responsive scaffolds promote bone repair and regeneration [127].…”

Optimization of Magnetic Cobalt Ferrite Nanoparticles for Magnetic Heating Applications in Biomedical Technology

“…Commonly used iron oxide nanoparticles can be tuned towards a higher anisotropy by changing their shape from spherical to cubic, disc-like or elongated needles [ 12 , 13 , 14 , 15 ]. Increasing their size while remaining in a single domain state also increases their coercivity [ 16 , 17 , 18 ]. Another approach to the synthesis of particles with large coercivities is the introduction of metal atoms such as Zn, Mg, Ba or Co into the crystal lattice to synthesize ferrites.…”