Ferritin heavy chain participated in ameliorating 3-nitropropionic acid-induced oxidative stress and apoptosis of goose follicular granulosa cells

Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides)

“…FTH1 mRNA expression in the laying goose ovary was found 13 times greater than in the prelaying goose ovary and considered to mediate the reproductive processes of geese ( Kang, et al, 2015 ). Interference with the FTH1 would lead to the shrinkage of GCs in goose follicles, an increase in the apoptosis rate of GCs, a significant increase in the number of dead GCs, promotion of the accumulation of ROS, and harm to MMP ( Yuan, et al, 2008 ; Jiang, et al, 2023 ). In this study, the expression level of FTH1 was significantly decreased in ASYFs compared to HSYFs group.…”

The Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells

“…It has been shown that exposure to H 2 O 2 in bovine follicular GCs leads to excessive accumulation of ROS and promotes apoptosis of GCs ( Sohel et al, 2018 ). Exposure to H 2 O 2 can induce overproduction of ROS, oxidative stress, follicular atresia in goose GCs, and impaired reproductive function in poultry ( Jiang et al, 2023 ). Nuclear factor erythroid 2-related factor 2 ( Nrf2 ), a crucial factor in the regulation of anti-oxidative stress, plays an important role in antioxidant response in the body ( Huang et al, 2021 ).…”