2015
DOI: 10.1002/jhet.2380
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Ferrocenyl, Alkyl, and Aryl‐Pyrido[2,3‐d]Pyrimidines as Vasorelaxant of Smooth Muscle of Rat Aorta via cAMP Conservation Through Phosphodiesterase Inhibition

Abstract: in Wiley Online Library (wileyonlinelibrary.com).New pyrido [2,3-d]pyrimidines 11, 12, 13, and 21 have been synthesized. The vasorelaxant effect on smooth muscle isolated from rat aorta, via PDEs inhibition, of these compounds along with other pyrido [2,3-d]pyrimidines 14-20 reported earlier by our group, has also been determined. These pyrido[2,3-d]pyrimidines 11-21 were synthesized by the reaction of ferrocenyl-ethynyl ketones (1-4) or α-alkynyl ketones (5-10) with 6-amino-1,3-dimethyluracil using [Ni(CN) 4 … Show more

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Cited by 6 publications
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