Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Zhang, Yongfa; Lü, Xin; Tai, Bai; Li, Weijia; Li, Tao

doi:10.3389/fncel.2021.615372

Cited by 73 publications

(56 citation statements)

References 124 publications

(155 reference statements)

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“…Stroke is mainly divided into ischemic stroke and intracerebral hemorrhage (ICH) stroke, the former accounting for a higher proportion [102]. Zhang et al [103] summarized the multiple roles of ferroptosis in stroke. Jin et al [104] reviewed some neuroprotectants that show protective effects in stroke models.…”

Section: Ferroptosis In Strokementioning

confidence: 99%

Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

Jia

Cheng

et al. 2022

Oxidative Medicine and Cellular Longevity

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With the acceleration of population aging, nervous system diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on families and society. The mechanism of neurological disorders is complex, which also lacks effective treatment, so relevant research is required to solve these problems urgently. Given that oxidative stress-induced lipid peroxidation eventually leads to ferroptosis, both oxidative stress and ferroptosis are important mechanisms causing neurological disorders, targeting mediators of oxidative stress and ferroptosis have become a hot research direction at present. Our review provides a current view of the mechanisms underlying ferroptosis and oxidative stress participate in neurological disorders, the potential application of molecular mediators targeting ferroptosis and oxidative stress in neurological disorders. The target of molecular mediators or agents of oxidative stress and ferroptosis associated with neurological disorders, such as reactive oxygen species (ROS), nuclear factor erythroid 2–related factor-antioxidant response element (Nrf2-ARE), n-acetylcysteine (NAC), Fe2+, NADPH, and its oxidases NOX, has been described in this article. Given that oxidative stress-induced ferroptosis plays a pivotal role in neurological disorders, further research on the mechanisms of ferroptosis caused by oxidative stress will help provide new targets for the treatment of neurological disorders.

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Section: Ferroptosis In Strokementioning

confidence: 99%

Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

Jia

Cheng

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…Ferroptosis is a recently described form of iron dependent cell death (Zhang et al, 2021c). Intracellular iron accumulation leads through the Fenton reaction to the formation of hydroxyl radicals that are ROS.…”

Section: Ferroptosismentioning

confidence: 99%

miRNA Involvement in Cerebral Ischemia-Reperfusion Injury

et al. 2022

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Cerebral ischemia reperfusion injury is a debilitating medical condition, currently with only a limited amount of therapies aimed at protecting the cerebral parenchyma. Micro RNAs (miRNAs) are small, non-coding RNA molecules that via the RNA-induced silencing complex either degrade or prevent target messenger RNAs from being translated and thus, can modulate the synthesis of target proteins. In the neurological field, miRNAs have been evaluated as potential regulators in brain development processes and pathological events. Following ischemic hypoxic stress, the cellular and molecular events initiated dysregulate different miRNAs, responsible for long-terming progression and extension of neuronal damage. Because of their ability to regulate the synthesis of target proteins, miRNAs emerge as a possible therapeutic strategy in limiting the neuronal damage following a cerebral ischemic event. This review aims to summarize the recent literature evidence of the miRNAs involved in signaling and modulating cerebral ischemia-reperfusion injuries, thus pointing their potential in limiting neuronal damage and repair mechanisms. An in-depth overview of the molecular pathways involved in ischemia reperfusion injury and the involvement of specific miRNAs, could provide future perspectives in the development of neuroprotective agents targeting these specific miRNAs.

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“…Previous studies show that ferroptosis is reversed by iron chelators (deferoxamine and ceruloplasmin), lipophilic antioxidants (ferrostatin-1, trolox, liproxstatin-1, and N -acetylcysteine (NAC)), and selenoprotein activator (selenium) ( Figure 7 ) ( Liu et al, 2021 ; Zhang et al, 2021 ). Then, significant progress has been made in preclinical studies targeting ferroptosis in the treatment of stroke.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric Analysis of Ferroptosis in Stroke From 2013 to 2021

Chen

Long

et al. 2022

Front. Pharmacol.

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Background: Stroke is a major cause of long-term disability and death, but the clinical therapeutic strategy for stroke is limited and more research must be conducted to explore the possible avenues for stroke treatment and recovery. Since ferroptosis is defined, its role in the body has become the focus of attention and discussion, including in stroke.Methods: In this work, we aim to systematically discuss the “ferroptosis in stroke” research by bibliometric analysis. Documents were retrieved from the Web of Science Core Collection database on October 30, 2021. Statistical analysis and visualization analysis were conducted by the VOSviewer 1.6.15.Results: Ninety-nine documents were identified for bibliometric analysis. Research on “ferroptosis in stroke” has been rapidly developing and has remained the focus of many scholars and organizations in the last few years, but the Chinese groups in this field still lacked collaboration with others. Documents and citation analysis suggested that Rajiv R. Ratan and Brent R. Stockwell are active researchers, and the research by Qingzhang Tuo, Ishraq Alim, and Qian Li are more important drivers in the development of the field. Keywords associated with lipid peroxidation, ferroptosis, iron, oxidative stress, and cell death had high frequency, but apoptosis, necroptosis, pyroptosis, and autophagy had scant research, and there may be more research ideas in the future by scholars.Conclusion: Further exploration of the mechanisms of crosstalk between ferroptosis and other programmed cell death may improve clinical applications and therapeutic effects against stroke. Scholars will also continue to pay attention to and be interested in the hot topic “ferroptosis in stroke”, to produce more exciting results and provide new insights into the bottleneck of stroke treatment.

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Ferroptosis and Its Multifaceted Roles in Cerebral Stroke

Cited by 73 publications

References 124 publications

Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

miRNA Involvement in Cerebral Ischemia-Reperfusion Injury

Bibliometric Analysis of Ferroptosis in Stroke From 2013 to 2021

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