Ferroptosis-Inducing Nanomedicine for Cancer Therapy

Wang, Yang; Liu, Tian‐Fu; Li, Xiang; Sheng, Hui; Ma, Xiaowen; Liang, Hao

doi:10.3389/fphar.2021.735965

Cited by 26 publications

(15 citation statements)

References 92 publications

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“…To date, hematological malignancies and metastatic solid tumors have caused a prevalence of over 10 million mortalities annually [3][4][5][6]. Antitumor immunotherapy Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges DOI: http://dx.doi.org/10.5772/intechopen.105184 has served as a promising and alternative strategy for improving the outcomes of tumor patients as well as reducing the concomitant cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…To date, thousands upon thousands of people suffer and even die from various tumors with high morbidity and mortality including malignant hematologic tumors and metastatic solid tumors worldwide, which have cause tremendous physical and mental stress to the patients and their guardians [1][2][3][4][5][6]. Despite the encouraging progresses in cancer treatment, one of the core dilemmas is the current limitation in classical therapeutic modalities such as surgery, radiation and chemotherapy [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, current progress has also highlighted the feasibility of nanomaterials (e.g., organic nanomaterials, inorganic nanomaterials, organic-inorganic hybrid nanomaterials) as promising agents for cancer therapy based on the knowledge of nanobiotechnology and clinical biomedicine [18][19][20]. However, the significant disadvantages of the aforementioned strategies are apparent and should not be ignored including drug delivery barriers, graft-versushost disease, off-target effects and severe toxicity [5,21,22].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges

Zhang¹,

Cai²

2023

Cytotoxicity - Understanding Cellular Damage and Response

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Immunotherapies are revolutionizing strategies for cancer treatment and infectious disease administration, which thus occupy worldwide concerns and enthusiasms for conquering relapsing and refractory immunodysfuction-related diseases. Current preclinical and clinical studies have suggested the partial success and promising potential of cancer management by various immunotherapies such as cancer vaccine, lymphocyte-promoting cytokines, checkpoint inhibitors and the cellular immunotherapy. However, the precise controlled modulation of the recipient’s immune system as well as the concomitant cytotoxicity remains the core challenge in the broad implementation of cancer immunotherapies. In this Chapter, we mainly focus on the latest updates of the cytotoxicity of cancer immunocytotherapy, together with the remarkable opportunities and conspicuous challenges, which represent the paradigm for boosting the immune system to enhance antitumor responses and ultimately eliminate malignancies. Collectively, we summarize and highlight the auspicious improvement in the efficacy and cytotoxicity of cancer immunotherapy and will benefit the large-scale preclinical investigations and clinical practice in adoptive immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges

Zhang¹,

Cai²

2023

Cytotoxicity - Understanding Cellular Damage and Response

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“…In recent years, as nanotechnology has rapidly developed, many engineered nanomaterials that could induce ferroptosis have been developed for applications in cancer therapy. Although ferroptosis-inducing nanomedicines show some unique advantages such as increasing the active targeting to tumors, prolong the half-life in the blood, and improving antitumor ability with the synergy effect, most of the current research was only based on cell lines or animal models ( 57 ). And the biosecurity, specific mechanisms, and potential clinical application of these emerging treatments remain to be further investigated.…”

Section: Discussionmentioning

confidence: 99%

Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field

Cheng

Guo²,

Shen³

et al. 2022

Front. Oncol.

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In recent years, ferroptosis has become a research hotspot in programmed cell death. Since the concept of ferroptosis was proposed, a growing number of articles have been published on this topic. Nevertheless, to our knowledge, these ferroptosis-related publications that have received a great deal of attention have not been quantitatively evaluated. In this study, we analyzed the top 100 most influential articles over the past decade through a bibliometric method to characterize the research status and trends in this field. Web of Science Core Collection was searched to identify relevant studies. After being manually screened, the top 100 most cited studies with original data were identified and analyzed. Bibliometric software including VOSviewer and R-Bibliometrix were used to perform visualization analysis. The citation frequency for the top 100 selected articles ranged from 135 to 3603 (326.6 citations on average). These articles originated from 25 countries/regions, with more than half originating from the United States and China. The most frequently nominated author was Stockwell BR from the Columbia University, and of the top 100 articles, 19 listed his name. Three core journals were Nature, Cell and Proceedings of the National Academy of Sciences of the United States of America. In addition to term of ferroptosis, these terms or phrases including cell death, cancer cell, GPX4, pathway, inhibitor, mechanism, iron, lipid peroxidation, resistance, erastin, sorafenib, P53, reactive oxygen species, necroptosis, apoptosis, glutathione peroxidase, ACSL4, autophagy, and SLC7A11 appeared more frequently in the top 100 articles. Overall, although much progress has been made, the research on ferroptosis is still at an early stage. The current attention in this field mainly focuses on potential regulatory mechanism and pathways including key ferroptosis-related genes/molecules, oxidant and antioxidant system, ferroptosis-inducing agents or nanomedicine for cancer therapy, as well as the role of ferroptosis in non-neoplastic disorders. Meanwhile, combination therapeutic strategies targeting ferroptosis in radiotherapy or immunotherapy also deserve further attention.

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“…Likewise, the combination of ferroptosis agonists (erastin and RSL3) and STAT3 (signal transducer and activator of transcription 3) inhibitors synergistically impaired the cisplatin resistance in osteosarcoma MG63 and Saos-2 cells (Liu and Wang, 2019). Recently, nanomedicine-based therapeutic methods have been applied to overcome treatment resistance and efficiently inhibit tumor development by inducing ferroptosis of tumor cells (Wang et al, 2021b). Fu et al constructed a nano-carrier loaded with ferrate and doxorubicin that could initiate the Fenton reaction to promote ROS overproduction and iron-dependent ferroptotic cell death, thus overcoming chemotherapy resistance in osteosarcoma cells both in vitro and in vivo (Fu et al, 2021).…”

Section: Ferroptosis Reduces Chemotherapy Resistance In Osteosarcomamentioning

confidence: 99%

Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications

Zhang

Yan

Cai

et al. 2023

Front. Cell Dev. Biol.

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Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies.

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Ferroptosis-Inducing Nanomedicine for Cancer Therapy

Cited by 26 publications

References 92 publications

Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges

Cancer Immunotherapy and Cytotoxicity: Current Advances and Challenges

Frontiers of ferroptosis research: An analysis from the top 100 most influential articles in the field

Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications

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