Ferroptosis participates in dibutyl phthalate-aggravated allergic asthma in ovalbumin-sensitized mice

Li, Yan; Yan, Biao; Wu, Yang Chang; Peng, Qi; Wei, Yaolu; Chen, Yenan; Zhang, Yuping; Ma, Ning; Xu, Yang; Ma, Ping

doi:10.1016/j.ecoenv.2023.114848

Cited by 22 publications

(2 citation statements)

References 57 publications

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“…It is reported that HMGB1 levels in sputum of asthmatic patients are significantly increased and positively correlated with asthma severity, obesity, and neutrophil percentage and significantly increased in lung tissue and bronchoalveolar lavage fluid (BALF) of asthmatic rats induced by ovalbumin (OVA) and positively correlated with obesity 79–81 . HMGB1 levels were negatively correlated with lung function in asthmatic patients 82–84 . This means that HMGB1 may be a potential biomarker of asthma severity 85 .…”

Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%

High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang,

Li,

Hou

et al. 2023

Immunity Inflam & Disease

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High‐mobility group box 1 (HMGB1) is a highly conserved nonhistone nuclear protein found in the calf thymus and participates in a variety of intracellular processes such as DNA transcription, replication and repair. In the cytoplasm, HMGB1 promotes mitochondrial autophagy and is involved in in cellular stress response. Once released into the extracellular, HMGB1 becomes an inflammatory factor that triggers inflammatory responses and a variety of immune responses. In addition, HMGB1 binding with the corresponding receptor can activate the downstream substrate to carry out several biological effects. Meanwhile, HMGB1 is involved in various signaling pathways, such as the HMGB1/RAGE pathway, HMGB1/NF‐κB pathway, and HMGB1/JAK/STAT pathway, which ultimately promote inflammation. Moreover, HMGB1 may be involved in the pathogenesis of asthma by regulating downstream signaling pathways through corresponding receptors and mediates a number of signaling pathways in asthma, such as HMGB1/TLR4/NF‐κB, HMGB1/RAGE, HMGB1/TGF‐β, and so forth. Accordingly, HMGB1 emerges as a therapeutic target for asthma.

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Section: The Role and Related Pathways Of Hmgb1 In Asthmamentioning

confidence: 99%

High‐mobility group box 1 emerges as a therapeutic target for asthma

Yang,

Li,

Hou

et al. 2023

Immunity Inflam & Disease

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“…Ferroptosis is an iron-dependent mode of cell death that plays a key role in the pathogenesis of lung disease ; therefore, targeting the associated pathways could be a novel strategy for the treatment of lung diseases, including idiopathic pulmonary fibrosis (IPF) (Guo et al, 2023a), ALI , lung cancer (Zhao et al, 2023), COPD (Yoshida et al, 2019), and asthma (Li et al, 2023). Irisin appears to be an important regulator of ferroptosis.…”

Section: Irisin and Cellular Pathwaysmentioning

confidence: 99%

Potential role of irisin in lung diseases and advances in research

Dong,

Lv,

Gao

et al. 2023

Front. Pharmacol.

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Irisin, a myokine, is secreted by the movement of skeletal muscles. It plays an important role in metabolic homeostasis, insulin resistance, anti-inflammation, oxidative stress, and bone metabolism. Several studies have reported that irisin-related signaling pathways play a critical role in the treatment of various diseases, including obesity, cardiovascular disease, diabetes, and neurodegenerative disorders. Recently, the potential role of irisin in lung diseases, including chronic obstructive pulmonary disease, acute lung injury, lung cancer, and their associated complications, has received increasing attention. This article aims to explore the role of irisin in lung diseases, primarily focusing on the underlying molecular mechanisms, which may serve as a marker for the diagnosis as well as a potential target for the treatment of lung diseases, thus providing new strategies for their treatment.

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