Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Xu, Rui; Yang, Jie; Qian, Yun; Deng, Huizi; Wang, Zhihua; Ma, Siyu; Wei, Yi; Yang, Nanying; Shen, Qi

doi:10.1039/d0nh00674b

Cited by 93 publications

(59 citation statements)

References 25 publications

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“…The typical pyroptotic pathway is sparked by the activation of nucleotide-binding domain leucine-rich repeats family protein 3 (NLRP3) inflammasomes as well as the associated inflammatory response [13,14]. Several reports have verified that pyroptosis plays a critical role in tumorigenesis and cancer treatment [15][16][17][18][19]. Notably, various cancers, including colon cancer [20,21], gastric cancer [22], hepatocellular carcinoma [23,24], breast cancer [25,26] and lung cancer [27,28], are sensitive to pyroptosis.…”

Section: Introductionmentioning

confidence: 99%

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

et al. 2021

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Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in recent years and has a poor prognosis. Pyroptosis is regulated via the activation of inflammasomes and participates in tumorigenesis. However, the effects of pyroptosis-related lncRNAs (PRlncRNAs) on LUAD have not yet been completely elucidated. Therefore, we attempted to systematically explore patterns of cell pyroptosis to establish a novel signature for predicting LUAD survival. Based on TCGA database, we set up a prognostic model by incorporating PRlncRNAs with differential expression using Cox regression and LASSO regression. Kaplan-Meier analysis was conducted to compare the survival of LUAD patients. We further simplified the risk model and created a nomogram to enhance the prediction of LUAD prognosis. Altogether, 84 PRlncRNAs with differential expression were discovered. Subsequently, a new risk model was constructed based on five PRlncRNAs, GSEC, FAM83A-AS1, AL606489.1, AL034397.3 and AC010980.2. The proposed signature exhibited good performance in prognostic prediction and was related to immunocyte infiltration. The nomogram exactly forecasted the overall survival of patients and had excellent clinical utility. In the present study, the five-lncRNA prognostic risk signature and nomogram are trustworthy and effective indicators for predicting the prognosis of LUAD.

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Section: Introductionmentioning

confidence: 99%

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

et al. 2021

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“…Furthermore, the concomitant methylene blue release induced fluorescence recovery, endowing the nanomaterials with multimodal imaging-guided PDT/FBT. In another example, Fe 3+ -containing MOFs loaded with piperlongumine (a FIN) were coated with a transferrin-decorated pH sensitive lipid layer to form the nanodrug ( Xu, R. et al, 2021 ). Crucially, after treatment with this nanoagent, the cellular iron concentration increased dramatically due to the iron-containing MOF, and piperlongumine strengthened the ferroptosis via providing H 2 O 2 for the dual induction system.…”

Section: Nanomaterials As Finsmentioning

confidence: 99%

Multifunctional Nanomaterials for Ferroptotic Cancer Therapy

et al. 2022

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Patient outcomes from the current clinical cancer therapy remain still far from satisfactory. However, in recent years, several biomedical discoveries and nanotechnological innovations have been made, so there is an impetus to combine these with conventional treatments to improve patient experience and disease prognosis. Ferroptosis, a term first coined in 2012, is an iron-dependent regulated cell death (RCD) based on the production of reactive oxygen species (ROS) and the consequent oxidization of polyunsaturated fatty acids (PUFAs). Many nanomaterials that can induce ferroptosis have been explored for applications in cancer therapy. In this review, we summarize the recent developments in ferroptosis-based nanomaterials for cancer therapy and discuss the future of ferroptosis, nanomedicine, and cancer therapy.

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“…Xu et al recently reported NPs inducing FERR decorated with TS (Table 2) [45]. The NPs were loaded with piperlongumine (FERR inducer, Figure 3) and covered with pH sensitive lipid membranes embedding TS (Tf-LipoMof@PL).…”

Section: Nanoparticles For Tumor Targetingmentioning

confidence: 99%

Nanoparticles for Ferroptosis Therapy in Cancer

Zaffaroni

Beretta

2021

Pharmaceutics

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Ferroptosis is a regulated cell death mechanism holding promise for anticancer therapy. Numerous small molecules inducing ferroptosis have been reported thus far. However, these compounds suffer from important drawbacks including poor solubility, systemic toxicity, and scarce tumor targeting ability that have limited their clinical success. The notion that nanoparticles inducing ferroptosis show better preclinical profiles compared to small molecules and overcome resistance to apoptosis has opened a new scenario for cancer treatment. Due to peculiar chemical-physical properties, nanoparticles can be loaded with anticancer drugs or decorated with tumor-selecting molecules. These features allow for drug combination treatment as well as tumor targeting. In the review, we summarize and discuss the available information concerning nanoparticles inducing ferroptosis endowed with different peculiarities and suitable for therapeutic purposes including nanoparticles for (i) antitumor drug delivery, (ii) tumor targeting, (iii) immunomodulation, and (iv) radiofrequency ablation, hyperthermia, and photodynamic therapy.

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Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Abstract: Non-apoptotic cell death such as ferroptosis and pyroptosis has shed new light on cancer treatment, while whose combinational therapy has not been fully explored yet. Herein, a dual-inductive nano-system to...

Cited by 93 publications

References 25 publications

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma

Multifunctional Nanomaterials for Ferroptotic Cancer Therapy

Nanoparticles for Ferroptosis Therapy in Cancer

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