Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

Xiao, Ruoxi; Wang, Shasha; Guo, Jing; Liu, Shihai; An-wei, Ding; Wang, Gongjun; Li, Wenqian; Zhang, Yuqi; Bian, Xiaoqian; Zhao, Shufen; Qiu, Wensheng

doi:10.1111/jcmm.17171

Cited by 50 publications

(20 citation statements)

References 31 publications

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“…Moreover, the typical features of ferroptosis include the inactivation of defensive GPX4 and the enhanced expression of the key protein ACSL4 during the formation of polyunsaturated-fatty-acid-containing phospholipids (PUFA-PLs). 38,39 Similar protein expression trends are shown in Fig. 5E, especially in the Simva-HMPB-Mn@GOx group.…”

Section: Resultssupporting

confidence: 66%

Metal-rich cascade nanosystem for dual-pathway ferroptosis resistance regulation and photothermal effect for efficient tumor combination therapy

Liu

Guan

et al. 2023

Biomater. Sci.

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Section: Resultssupporting

confidence: 66%

Metal-rich cascade nanosystem for dual-pathway ferroptosis resistance regulation and photothermal effect for efficient tumor combination therapy

Liu

Guan

et al. 2023

Biomater. Sci.

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“…CHAC1, ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1, is a protein-coding gene. CHAC1 was reported to be a ferroptosis-related gene, and mainly explored in various cancers [ 40 – 42 ], while no related finding was reported in stroke disease. The research focus on miR-760-3p was rare, and only one study reported that it was related to inflammatory [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

Wang

Niu

et al. 2023

J Nanobiotechnol

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Ferroptosis plays a critical role in ischemic stroke, and anti-ferroptosis strategies were regarded as potentially effective measures. Based on ferroptosis-related mechanisms, this study aims to design and prepare anti-ferroptosis exosomes from adipose-derived mesenchymal stem cells (ADSC-Exo) for treating ischemic brain injury via intranasal (IN) administration. According to the bioinformatic analysis, CHAC1 was a key gene in the progress of ferroptosis in ischemic stroke. miR-760-3p can inhibit the expression of CHAC1 and may be abundant in ADSC-Exo. Therefore, ADSC-Exo were successfully isolated and the immunofluorescence showed that they can be efficiently delivered to the brain via IN administration. Additionally, IN administration of ADSC-Exo can effectively improve the neurobehavior function of mice after I/R, and improve the ferroptosis-related outcomes. As the immunofluorescence showed the co-localization of NeuN with CHAC1 obviously, we further evaluated the systematic effect of ADSC-Exo in an oxygen–glucose deprivation (OGD) mouse neuroblastoma cell line N2a model. The results showed that miR-760-3p in ADSC‐Exo contributed to their function in inhibiting ferroptosis by targeting CHAC1 in neurons. Collectively, the present study successfully designed and prepared anti-CHAC1 ADSC-Exo and suggested a promising exosome-based strategy for anti-ferroptosis therapy in cerebral ischemia/reperfusion injury. Graphical abstract

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“…[33] CHAC1 is a ferroptosis-related gene, and its increased expression indicates an increased risk of cancer recurrence in patients with breast and gastric cancer. [34,35] TRIB3 reduces CD8 T cell infiltration and induces immune escape by inhibiting the STAT1-CXCL10 axis in colorectal cancer. [36] TRIB3 promotes the development of MYC-associated lymphoma by inhibiting UBE3B-mediated degradation of MYC.…”

Section: Discussionmentioning

confidence: 99%

Identification and validation of a genetic risk signature associated with prognosis in clear-cell renal cell carcinoma patients

Lian

Feng

et al. 2023

Medicine

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Clear-cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), which exhibits great variability in the prognosis of patients. Endoplasmic reticulum stress (ERS) is a persistent state triggered by disruption of endoplasmic reticulum (ER) homeostasis, which has been shown to control multiple pro-tumor-associated pathways in malignant cells while dynamically reprogramming immune cell function. This study aimed to identify ERS-related genetic risk signatures (ERSGRS) to ameliorate survival prediction in ccRCC patients. In this study, we adopted differentially expressed genes (DEGs) from the Cancer Genome Atlas (TCGA) and constructed ERSGRS with independent prognostic significance by least absolute shrinkage and selection operator (LASSO) regression. After separation of patients based on risk score, survival analysis showed that low-risk patients had longer overall survival (OS) than high-risk patients, and receiver operating characteristic (ROC) curve analysis confirmed the strong predictive ability of ERSGRS. Meanwhile, the tumor microenvironment (TME) of the high-risk group demonstrated an immunosuppressive phenotype, with more infiltration of regulatory T cells (Tregs) and macrophages. The TME in the low-risk group had a stronger potential for anti-tumor immunity. Overall, the ERSGRS could be a valuable predictive tool for ccRCC prognosis.

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Ferroptosis‐related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 50 publications

References 31 publications

Metal-rich cascade nanosystem for dual-pathway ferroptosis resistance regulation and photothermal effect for efficient tumor combination therapy

Metal-rich cascade nanosystem for dual-pathway ferroptosis resistance regulation and photothermal effect for efficient tumor combination therapy

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis

Identification and validation of a genetic risk signature associated with prognosis in clear-cell renal cell carcinoma patients

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