2022
DOI: 10.3390/biology11070950
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Ferroptosis-Related Proteins Are Potential Diagnostic Molecular Markers for Patients with Preeclampsia

Abstract: Preeclampsia (PE) is the leading cause of maternal and fetal mortality and morbidity. Early and accurate diagnosis is critical to reduce mortality. Placental oxidative stress has been identified as a major pathway to the development of PE. Ferroptosis, a new form of regulated cell death, is associated with iron metabolism and oxidative stress, and has been suspected to play a role in the pathophysiology of PE, although the mechanism is yet to be elucidated. The identification of potential ferroptosis-related b… Show more

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Cited by 3 publications
(1 citation statement)
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“…Furthermore, we identified noteworthy overlap with PE dysregulated genes that are known to be increased in stage 2 of PE, such as SAT1. SAT1 has been bioinformatically associated with PE physiopathology multiple times throughout literature, although the underlying mechanism remains poorly explored 40,41 . Overall, our study strikingly implicates unwarranted IFN signaling as a maternal disturbance that could trigger PE.…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, we identified noteworthy overlap with PE dysregulated genes that are known to be increased in stage 2 of PE, such as SAT1. SAT1 has been bioinformatically associated with PE physiopathology multiple times throughout literature, although the underlying mechanism remains poorly explored 40,41 . Overall, our study strikingly implicates unwarranted IFN signaling as a maternal disturbance that could trigger PE.…”
Section: Discussionmentioning
confidence: 99%