Platelets are circulating cells known for their contribution to hemostasis, coagulation, protecting the blood vessels integrity, and wound healing. In the last decade, increasing evidence has linked platelets to activities beyond that. Platelets have been implicated in many physiological and pathological conditions involving immunity, inflammation, and even malignant tumors. Their role has been evaluated both as prognostic and diagnostic markers. Interestingly, platelets communicate with each other through a range of cytokines and interleukins secreted by their intracellular granules once activated or triggered. The understanding of this sophisticated mechanism of secretion and the genetic guidance of granule biosynthesis remained unclear. Complete blood count and its parameters are informative and affordable diagnostic tests as they highlighted platelet counts, plateletcrit, platelet indices; mean platelet volume, and platelet distribution width. Recently, increasing evidence suggests that implementing these parameters is a useful biomarker in the field of gynecology. Their role in obstetrics has been discussed in many studies, especially in hypertensive diseases, diabetes, abnormal fetal growth pattern, and early pregnancy loss. This review outlines the role of platelets and their indices in Gynecological disease.