Fertility Assessment in Sorraia Stallions by Sperm‐Fish and <i>Fkbp6</i> Genotyping

Kjöllerström, H.J.; Oom, María do Mar; Chowdhary, B.P.; Raudsepp, Terje

doi:10.1111/rda.12686

Cited by 3 publications

(2 citation statements)

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“…Owing to these limitations, sperm-FISH studies in stallions have been restricted to analyzing sex chromosome aneuploidies in reproductively normal [179][180][181] and subfertile stallions [182]. These studies indicate that sex chromosome aneuploidy rate in normal stallions is in the range of 0.32-1.14% [179][180][181] with the highest frequency for sex chromosome nullisomy (0.47-1.22%) and the lowest for trisomy XXX or XXY (0.008-0.02%) [180,181].…”

Section: Cytogenetic Evaluation Of Stallions By Sperm-fishmentioning

confidence: 99%

“…Correlation has also been found between stallion age and the total number of aberrations in sperm [180,181]. Compared to normal stallions, subfertile Sorraia stallions have over five times more (5.83%) sex chromosome aneuploidies [182], whereas stallions in general show the highest rate of X and Y aneuploidies among domestic species (reviewed by [14]). Based on these data, it is tempting to speculate that the relatively high frequency of X-monosomy found in horses (see Section 3.2.)…”

Section: Cytogenetic Evaluation Of Stallions By Sperm-fishmentioning

confidence: 99%

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Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Bugno‐Poniewierska

Raudsepp

2021

Animals

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Clinical cytogenetic studies in horses have been ongoing for over half a century and clearly demonstrate that chromosomal disorders are among the most common non-infectious causes of decreased fertility, infertility, and congenital defects. Large-scale cytogenetic surveys show that almost 30% of horses with reproductive or developmental problems have chromosome aberrations, whereas abnormal karyotypes are found in only 2–5% of the general population. Among the many chromosome abnormalities reported in the horse, most are unique or rare. However, all surveys agree that there are two recurrent conditions: X-monosomy and SRY-negative XY male-to-female sex reversal, making up approximately 35% and 11% of all chromosome abnormalities, respectively. The two are signature conditions for the horse and rare or absent in other domestic species. The progress in equine genomics and the development of molecular tools, have qualitatively improved clinical cytogenetics today, allowing for refined characterization of aberrations and understanding the underlying molecular mechanisms. While cutting-edge genomics tools promise further improvements in chromosome analysis, they will not entirely replace traditional cytogenetics, which still is the most straightforward, cost-effective, and fastest approach for the initial evaluation of potential breeding animals and horses with reproductive or developmental disorders.

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Section: Cytogenetic Evaluation Of Stallions By Sperm-fishmentioning

confidence: 99%

Section: Cytogenetic Evaluation Of Stallions By Sperm-fishmentioning

confidence: 99%

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Bugno‐Poniewierska

Raudsepp

2021

Animals

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Genetics of Equine Reproductive Diseases

Raudsepp

2020

Veterinary Clinics of North America: Equine Practice

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No general effects of advancing male age on ejaculates: a meta-analysis across the animal kingdom

Sanghvi

Vega‐Trejo

Nakagawa³

et al. 2023

Preprint

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Senescence, the deterioration of organismal function with advancing age, is a puzzling biological phenomenon. While actuarial senescence (i.e., age-dependent increases in mortality rates) is well described across some taxa, reproductive senescence (i.e.age- dependent declines in reproduction) is less understood, especially in males, with mixed patterns reported across studies. To examine the evidence for male reproductive senescence, we investigated how advancing male age affects ejaculate traits across non-human animals via a meta-analysis yielding 1814 effect sizes from 379 studies. We found no evidence for a general pattern of reproductive senescence. Instead, we found high heterogeneity for how reproduction changes with male age across animals. Some of this heterogeneity (>10%) was associated with biological factors. For example, there were taxonomical differences for some ejaculate traits — sperm motility declined with male age in lab rodents and fish, whereas ejaculate size improved with male age in bulls, fish, and insects. Some methodological factors were also important in explaining this heterogeneity: studies sampling a larger proportion of a species’ lifespan were more likely to detect senescence in ejaculate traits, emphasising the need to examine the full life cycle of species to document senescence. Contrary to predictions, we reveal that the evidence for senescence in ejaculate traits is sporadic. Our findings will help generate novel hypotheses and identify more effective methodological approaches for studying male reproductive senescence.

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Fertility Assessment in Sorraia Stallions by Sperm‐Fish and Fkbp6 Genotyping

Cited by 3 publications

References 51 publications

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Horse Clinical Cytogenetics: Recurrent Themes and Novel Findings

Genetics of Equine Reproductive Diseases

No general effects of advancing male age on ejaculates: a meta-analysis across the animal kingdom

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