Fertility responses of melatonin-treated gilts before and during the follicular and early luteal phases when there are different temperatures and lighting conditions in the housing area

Arend, Lídia S; Knox, Robert V.

doi:10.1016/j.anireprosci.2021.106769

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Seasonal effects are more evident with extensively or semi-extensively reared animals, tropical climates, farms with limited control of the environment, or local breeds with low genetic selection [ 35 ]. Other environmental effects such as the photoperiod or an effect on semen quality could be highly relevant, at least in some cases [ 19 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Season and Parity on Reproduction Performance of Iberian Sows Bred with Duroc Semen

Piñán

Alegre

Kirkwood

et al. 2021

Animals

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The Iberian pig is an autochthonous breed from the Iberian Peninsula highly valued for its meat. The sows are often bred as Iberian × Duroc crossings for increased efficiency. Since sow parity and season affect the reproductive performance, we evaluated two-year records from a commercial farrow-to-finish farm (live, stillborn, and mummified piglets after artificial insemination, AI). A total of 1293 Iberian sows were inseminated with semen from 57 boars (3024 AI). The effects of parity (gilts, 1, 2–4, 5–10, and >10 farrowings) and season were analyzed by linear mixed-effects models (LME). The data were fitted to cosinor models to investigate seasonal effects within parity groups. The effects of maximum daily temperature (MDT) and day length change (DLC) during spermatogenesis, pre-AI, and post-AI periods were analyzed with LME. The 2–4 group was the optimal one for parity. A seasonal effect was evident between spring–summer (lower fertility/prolificacy) and autumn–winter (higher). Cosinor showed that the seasonal drop in reproductive performance occurs earlier in Iberian sows than in other breeds, more evident in gilts. MDT negatively affected performance in all periods and DLC in spermatogenesis and pre-AI. These results are relevant for the improvement of Iberian sows’ intensive farming.

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Section: Discussionmentioning

confidence: 99%

Effect of Season and Parity on Reproduction Performance of Iberian Sows Bred with Duroc Semen

Piñán

Alegre

Kirkwood

et al. 2021

Animals

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“…МТ представляет собой плейотропную молекулу, которая регулирует различные процессы, включая беременность. Применение МТ в условиях теплового стресса у свиней улучшает качество и скорость созревания ооцитов (частично за счёт восстановления распределения F-актина) [17], оказывает положительное влияние на продолжительность эстрального периода и выживаемость эмбрионов [18]. Использование МТ снижает выработку АФК в созревающих ооцитах крупного рогатого скота и повышает способность к развитию эмбрионов из ооцитов, подвергшихся тепловому шоку [17].…”

Section: Microphotographs Of Rat Ovarian Corpus Luteum On Day 14 Afte...unclassified

The effect of melatonin on the Bcl-2 and Bad proteins expression in ovarian corpus luteum cells after exposure to experimental hyperthermia

Michurina,

Kolesnikov,

Ishchenko

et al. 2024

Acta biomedica scientifica

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Background. There is growing interest in determining the role of melatonin in the regulation of proliferation and apoptosis of ovarian cells at various diseases and destabilizing influences. It is believed that the choice between the implementation of a cell death or survival program determines the ratio of anti-apoptotic and pro-apoptotic proteins.The aim. To identify the effect ofmelatonin onthe expression ofanti-apoptotic Bcl-2 and pro-apoptotic Bad and the Bcl-2/Bad ratio in the ovarian luteocytes of Wistar rats in the acute (day 3) and recovery (days 7 and 14) periods after a single exposure to experimental hyperthermia.Methods. Warming up took no more than 17 minutes. Melatonin was injected subcutaneously (0.1 mg in 0.2 ml of physiological solution) for 3 days after experimental hyperthermia. Comparison groups included rats with physiological solution injection (control) and animals after experimental hyperthermia + physiological solution injection. The Bad and Bcl-2 expression was determined immunohistochemically on days 3, 7 and 14 after experimental hyperthermia + physiological solution or melatonin injection.Results. On the day 3 after experimental hyperthermia, the effect of the hormone was not detected. A week after experimental hyperthermia + melatonin injection, the Bad expression area decreased more significantly than in rats after experimental hyperthermia + physiological solution injection, which led to an increase in Bcl-2/ Bad ratio. This indicated an increase in anti-apoptotic protection, blocking the development of the internal apoptosis pathway at this time. 2 weeks after experimental hyperthermia + physiological solution injection, the Bcl-2 area decreased more significantly than the Bad area. As a result, the Bcl-2/Bad ratio decreased almost 2-fold compared to the control group. This indicated the activation of the “mitochondrial branch” of luteocyte apoptosis. 2 weeks after experimental hyperthermia + melatonin injection, the Bad and Bcl-2 areas decreased synchronously, which restored Bcl-2/ Bad to control values.Conclusion. The melatonin injection after experimental hyperthermia shifts the ratio of Bcl-2/Bad expression areas towards an increase in anti-apoptotic Bcl2 already a week after the recovery period and promotes earlier normalization of Bcl-2/Bad to physiological levels (as early as 2 weeks after experimental hyperthermia + melatonin injection).

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“…At the same time, a positive correlation was observed between serum melatonin concentration and fertility (32)(33)(34)(35)(36). Administration of exogenous melatonin is associated with a higher percentage of maintained pregnancies (37). Melatonin also participates in the activity changes of the female immune system during pregnancy in sheep, influencing the immune activity of the thymus, lymph nodes and spleen, which are involved in the process of fetal immune tolerance.…”

Section: In Vivo Animal Studiesmentioning

confidence: 99%

Endocrine disorders and fertility and pregnancy: An update

et al. 2023

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It is estimated that more and more couples suffer from fertility and pregnancy maintenance disorders. It is associated with impaired androgen secretion, which is influenced by many factors, ranging from genetic to environmental. It is also important to remember that fertility disorders can also result from abnormal anatomy of the reproductive male and female organ (congenital uterine anomalies – septate, unicornuate, bicornuate uterus; acquired defects of the uterus structure – fibroids, polyps, hypertrophy), disturbed hormonal cycle and obstruction of the fallopian tubes resulting from the presence of adhesions due to inflammation, endometriosis, and surgery, abnormal rhythm of menstrual bleeding, the abnormal concentration of hormones. There are many relationships between the endocrine organs, leading to a chain reaction when one of them fails to function properly. Conditions in which the immune system is involved, including infections and autoimmune diseases, also affect fertility. The form of treatment depends on infertility duration and the patient’s age. It includes ovulation stimulation with clomiphene citrate or gonadotropins, metformin use, and weight loss interventions. Since so many different factors affect fertility, it is important to correctly diagnose what is causing the problem and to modify the treatment regimen if necessary. This review describes disturbances in the hormone secretion of individual endocrine organs in the context of fertility and the maintenance of pregnancy.

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Fertility responses of melatonin-treated gilts before and during the follicular and early luteal phases when there are different temperatures and lighting conditions in the housing area

Cited by 4 publications

References 31 publications

Effect of Season and Parity on Reproduction Performance of Iberian Sows Bred with Duroc Semen

Effect of Season and Parity on Reproduction Performance of Iberian Sows Bred with Duroc Semen

The effect of melatonin on the Bcl-2 and Bad proteins expression in ovarian corpus luteum cells after exposure to experimental hyperthermia

Endocrine disorders and fertility and pregnancy: An update

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