Ferulic acid – A novel topical agent in reducing signs of photoaging

Abstract

Continuous production of reactive oxygen species, induced by UV radiation, is one of the main mechanisms contributing to skin photoaging. Therefore, the use of novel superior antioxidants, which ferulic acid belongs to, is an innovative treatment option. The aim of this study was to evaluate the effect of 14% ferulic acid peel on skin hydration, topography, the level of melanin, and the severity of erythema, in people with skin photoaging symptoms. Twenty women aged 45–60, received eight treatments of chemical peeling in 1‐week intervals. Efficacy was measured using The Multi Probe Adapter (MPA) Systems (Courage + Khazaka electronic GmbH, Köln, Germany). The measurements were taken before, 8, and 12 weeks after the first treatment. Additionally, the photo documentation was made with Fotomedicus (Elfo) and VISIA® Complexion Analysis System (Canfield Scientific, Inc.). The objective evaluation showed statistically significant improvement in all measured skin parameters p < 0.05). The best results of skin hydration and melanin level were observed right after the end of the series (p < 0.001). The best improvement in erythema reduction was noted a month after the last treatment (p < 0.0001). At the control, untreated point none of the probes showed statistically significant changes. In conclusion, a series of treatments with 14% ferulic acid peel has a significant bleaching, erythema‐reducing, and moisturizing activity. The results achieved by apparatus, are reflected by photo documentation. The effects achieved during a series persist over time.

Exploring the Potential of Supercritical Fluid Extraction of Matricaria chamomilla White Ray Florets as a Source of Bioactive (Cosmetic) Ingredients

“…It efficiently alleviates the negative effects of UVinduced oxidative stress [93,94]. In vivo studies have confirmed ferulic acid skin firming, moisturizing, and pigmentation regulating activity [95].…”

Metabolic shifts during coffee consumption refresh the immune response: insight from comprehensive multiomics analysis

“… 16 , 17 FA supplementation can effectively delay immunosenescence. Therefore, it is widely used as an antiphotoaging agent in skin, 18 , 19 but its molecular mechanism remains unclear. Abundances of PS, a lipid metabolite, increased significantly in habitual coffee consumers.…”

Interaction between the microbiota and the skin barrier in aging skin: a comprehensive review

“…While α-tocopherol (free vitamin E) is renowned for stabilizing the lamellar lipid layers in the SC (Thiele, 2001), other antioxidants like vitamin C have also demonstrated clinical improvements in aging skin when applied topically (Thiele and Ekanayake-Mudiyanselage, 2007). Moreover, the advancements in skin care have introduced a variety of other topical antioxidants, such as ferulic acid, resveratrol, and niacinamide (Baxter, 2008;Boo, 2021;Zduńska-Pęciak et al, 2022), which, when used individually or synergistically, offer a robust defense against oxidative stress and enhance the skin's resilience against environmental aggressors like UV radiation (Baxter, 2008;Farris et al, 2014;Hahn et al, 2016;Rattanawiwatpong et al, 2020;Boo, 2021;Zduńska-Pęciak et al, 2022).…”