Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

Li, Dan; Rui, Yixin; Guo, Shi-duo; Luan, Fei; Liu, Rong; Zeng, Nan

doi:10.1016/j.lfs.2021.119921

Cited by 283 publications

(170 citation statements)

References 118 publications

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“…Ferulic acid is extensively distributed throughout the plant world, particularly in the Ranunculaceae and Gramineae families [85]. Ferulic acid is frequently associated with lignin and polysaccharide to constitute plant cell walls, although it is seldom seen in its pure form.…”

Section: Discussionmentioning

confidence: 99%

“…It seems to protect against renal [87,88] and cardiovascular diseases [89]. Ferulic acid may also prevent thrombosis by inhibiting platelet aggregation and the production of thromboxane-like compounds [90], inhibiting hepatic cholesterol synthesis in lower blood lipid [91], and preventing coronary heart disease [92] and atherosclerosis [85], among other things. Phenolic compounds, especially flavonoids, appear to be the main substances responsible for bone marrow protection against the deleterious effects of phenylhydrazine [77].…”

Section: Discussionmentioning

confidence: 99%

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Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats

Ousaaid

Laaroussi

Bakour

et al. 2022

Life

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This study aims to examine the ability of apple vinegar on phenylhydrazine (PHZ)-induced hemolytic anemia in Wistar rats. In vitro, phenolic and flavonoid content and antioxidant activity were determined. In vivo, phenylhydrazine (10 mg/kg) was injected intravenously into rats for 4 days and then treated with apple vinegar daily by gavage (1 mL/kg) for five weeks. high level of polyphenols and flavonoids (90 ± 1.66 mg GAE/100 mL and 7.29 ± 0.23 mg QE/100 mL, respectively) were found in the apple vinegar which gives it a good ability to scavenge free radicals (TAC = 4.22 ± 0.18 mg AAE/100 mL and DPPH, IC50= 0.49 ± 0.004 µL/mL). The phytochemical composition of apple vinegar revealed the presence of numerous bioactive compounds including arbutin, apigenin, sinapic, ferulic and trans-ferulic acids. The major antioxidant components in apple vinegar were ferulic and trans-ferulic acids (40% and 43%, respectively). PHZ treatment induced changes in platelets, blood cell count, mean corpuscular volume, hemoglobin concentration and mean capsulated hemoglobin. However, the co-administration of apple vinegar revealed its capacity to ameliorate the changes induced by phenylhydrazine. Therefore, apple vinegar use could have a positive impact on the prevention of hemolytic anemia induced by phenylhydrazine due to the antioxidant properties of its major components.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats

Ousaaid

Laaroussi

Bakour

et al. 2022

Life

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show abstract

“…Ferulic acid (FA) is a naturally occurring phenolic phytocompound that is abundantly found in cereals, citrus fruits, and beverages. Extensive pre-clinical and clinical investigations on UA have suggested its wide range of therapeutic potentials such as antioxidant, antidiabetic, anticancer, and pulmonary protective activity [174][175][176][177]. Moreover, its low toxicity makes it a potential candidate in food as well as in the pharmaceutical field [178].…”

Section: Ferulic Acidmentioning

confidence: 99%

Recent Advancement in Chitosan-Based Nanoparticles for Improved Oral Bioavailability and Bioactivity of Phytochemicals: Challenges and Perspectives

et al. 2021

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The excellent therapeutic potential of a variety of phytochemicals in different diseases has been proven by extensive studies throughout history. However, most phytochemicals are characterized by a high molecular weight, poor aqueous solubility, limited gastrointestinal permeability, extensive pre-systemic metabolism, and poor stability in the harsh gastrointestinal milieu. Therefore, loading of these phytochemicals in biodegradable and biocompatible nanoparticles (NPs) might be an effective approach to improve their bioactivity. Different nanocarrier systems have been developed in recent decades to deliver phytochemicals. Among them, NPs based on chitosan (CS) (CS-NPs), a mucoadhesive, non-toxic, and biodegradable polysaccharide, are considered the best nanoplatform for the oral delivery of phytochemicals. This review highlights the oral delivery of natural products, i.e., phytochemicals, encapsulated in NPs prepared from a natural polymer, i.e., CS, for improved bioavailability and bioactivity. The unique properties of CS for oral delivery such as its mucoadhesiveness, non-toxicity, excellent stability in the harsh environment of the GIT, good solubility in slightly acidic and alkaline conditions, and ability to enhance intestinal permeability are discussed first, and then the outcomes of various phytochemical-loaded CS-NPs after oral administration are discussed in detail. Furthermore, different challenges associated with the oral delivery of phytochemicals with CS-NPs and future directions are also discussed.

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“…Wheat bran is composed primarily of arabinoxylan (38–55% of dry mass), cellulose (16–30%), and esterified ferulic acid ( ∼ 1%). Ferulic acid (FA) offers value as an antimicrobial compound with antioxidant properties, and it can additionally serve as a preservative for food products ( Li et al, 2021 ; Hu et al, 2022 ). Moreover, it can be converted into vanillin for use as a flavoring agent in the food and perfume industries ( Ferri et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Improved Release of Monosaccharides and Ferulic Acid Using Enzyme Blends From Aspergillus Niger and Eupenicillium Parvum

Liu

Shi

Feng

et al. 2022

Front. Bioeng. Biotechnol.

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Supplementing commercial xylanase and cellulase with selected debranching enzymes only resulted in slight enhancement of the enzymatic hydrolysis of wheat bran autohydrolysis residues (WBAR) which was obtained at 160°C over a 30-min period of autohdyrolysis, while a blend of enzymes from Aspergillus niger and Eupenicillium parvum achieved synergistic efficacy in this context. Using an equal mixture blend of these enzymes at a 0.5% (w/w) enzyme loading dosage with the addition of ferulic acid esterase (1 U/g substrate), the obtained hydrolysis yields were desirable, including 84.98% of glucose, 84.74% of xylose, 80.24% of arabinose, and 80.86% of ferulic acid. Following further separation using an HP-20 resin, the final ferulic acid recovery levels were as high as 62.5% of the esterified ferulic acid present within the initial WBAR input. Together, these data suggest that a combination of autohydrolysis and enzymatic hydrolysis using crude enzyme blends can efficiently achieve wheat bran enzymatic saccharification and associated ferulic acid release.

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Ferulic acid: A review of its pharmacology, pharmacokinetics and derivatives

Cited by 283 publications

References 118 publications

Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats

Anti-Anemic Effect of Antioxidant-Rich Apple Vinegar against Phenylhydrazine-Induced Hemolytic Anemia in Rats

Recent Advancement in Chitosan-Based Nanoparticles for Improved Oral Bioavailability and Bioactivity of Phytochemicals: Challenges and Perspectives

Improved Release of Monosaccharides and Ferulic Acid Using Enzyme Blends From Aspergillus Niger and Eupenicillium Parvum

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