Ferulic acid alleviates lipid peroxidation in diabetic rats

Abstract

Diabetes mellitus is a metabolic disorder associated with increased formation of free radicals. The objective of our study was to determine whether ferulic acid (FA), a phenolic acid, has any role to play in diabetes induced free radical formation. Diabetes was induced with streptozotocin. The levels of blood glucose, thiobarbituric acid reactive substances (TBARS), hydroperoxides and free fatty acids (FFA) increased in the liver of diabetic animals. The activities of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) decreased in the liver. Histopathology of pancreas also shows shrunken islets. Supplementation of FA to the diabetic rats resulted in a decrease in the levels of glucose, TBARS, hydroperoxides, FFA and an increase in reduced glutathione (GSH). FA also resulted in increased activities of SOD, CAT, GPx and expansion of pancreatic islets. The effect was much pronounced with lower dose treatment. Thus our study shows that administration of ferulic acid helps in enhancing the antioxidant capacity of these diabetic animals by neutralizing the free radicals formed thereby reducing the intensity of diabetes.

In Vivo Anti-diabetic Effects of Aqueous Leaf Extracts of Rhoicissus tridentata in Alloxan Induced Diabetic Mice

“…Flavonoid and terpenes isolated from the other antidiabetic medicinal plants has been found to stimulate secretion or possess an insulin like-effect [27]. Effect of the flavonoids quercetin and ferulic acid on pancreatic β-cells leading to their proliferation and secretion of more insulin have been proposed by [28,29] as the mechanism by which they reduced hyperglycaemia caused by streptozocin in diabetic rats. The flavonoids present in c may also be acting similarly.…”

Effects of NaCl and Lime water on the Hypoglycemic and Antioxidant activities of Ocimum gratissimum in Alloxan-induced Diabetic rats.

“…Several studies have shown that antioxidants ameliorate a number of altered physiological and metaboli c parameters that occur as a result of type-2-diabetes [21,22]. Also in clinical, experimental in vivo and in vitro models of diabetes, antioxidant potential correlates with the degree of glycemic control and it decreases with pro longed diabetes [23].…”

Identification and Characterization of Feruloyl Esterases Produced by Probiotic Bacteria

“…The sugar beet pulp is an important source of ferulic acid, a phytophenol with antioxidative and anti-inflammatory effects (Couteau et al, 1998). It has been demonstrated that low dosage of cinnamic acids (especially ferulic acid) has been related with the stimulation of insulin secretion (Balasubashini et al, 2003, Adisakwattana et al, 2008, prevention of oxidative stress and lipid peroxidation (Balasubashini et al, 2004, Srinivasan et al, 2007, and inhibition of diabetic nephropathy progression (Fujita et al, 2008). The interaction of select bacteria in the host intestines with dietary fiber, and the possible release of phenolic acids, is an interesting process to be analyzed in order to generate a rationale understanding of the problem.…”