Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review

Singh, Surbhi; Arthur, Richmond; Upadhayay, Shubham; Kumar, Puneet

doi:10.1016/j.prmcm.2022.100190

Cited by 18 publications

(10 citation statements)

References 72 publications

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“…In Chinese medicinal science, ferulic is normally joined with polysaccharides by covalent bonds in various plant cell walls such as cereal bran and regarded as the main bioactive compound of Angelica sinensis , chuanxiong rhizoma, and ferula [ 307 ], and it has several biological activities such as anti-apoptosis, anticancer, antioxidant, and anti-inflammatory impacts [ 308 ]. Free ferulic acid is related to the natural content of ferulic acid in herbs, and total ferulic acid refers to the sum of free ferulic acid plus the amount of related hydrolyzed components [ 309 , 310 ]. Angelica sinensis is a perennial herbaceous species that creates the bioactive metabolite ferulic acid [ 311 , 312 ].…”

Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Section: Hydroxycinnamic Acids ( P -Coumaric Acid ...mentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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“…progeroid syndromes caused by gene mutations, including Werner syndrome, RothmundThomson syndrome, Cockayne syndrome, ataxiatelangiectasia, and Down syndrome. Progeria is an inherited form of premature aging that frequently mani fests as accelerated skin aging phenotypes, such as skin atrophy and sclerosis, poikiloderma, alopecia, thinning hair, and greying of the hair [29,30]. 5. role of MicrorNA (mirNA) Research showed that DNA meth yltransferase 1's (DNMT1) main function following DNA replica tion is to maintain the daughter strands' methylation status in order to ensure that the methylated strand was transmitted to the progeny cells.…”

Section: Genetic Mutation Researchers Have Given Information Onmentioning

confidence: 99%

“…Researchers have given information on progeroid syndromes caused by gene mutations, including Werner syndrome, Rothmund-Thomson syndrome, Cockayne syndrome, ataxia-telangiectasia, and Down syndrome. Progeria is an inherited form of premature aging that frequently manifests as accelerated skin aging phenotypes, such as skin atrophy and sclerosis, poikiloderma, alopecia, thinning hair, and greying of the hair 29 30 .…”

Section: Introductionmentioning

confidence: 99%

“…Sulphonyl glucuronide, the prima ry metabolite of FA in plasma, is produced by the liver enzymes sul fotransferase and uridine-5,1-diphthoglucuronocyltransferase (UDP glucuronosyltransferase). Moreover, as these metabolites are eliminated via the kidney, the kidney and intestinal mucosa play a significant role in FA metabolism [4][5][6][7]. [11].…”

Section: Introductionmentioning

confidence: 99%

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Ferulic Acid: Signaling Pathways in Aging

Neopane,

Ansari,

Singh

2023

Drug Res (Stuttg)

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The need for clinical remedies to the multiple age-related deficiencies in skin function brought on by extrinsic and intrinsic causes is increased by these demographic changes. Reactive oxygen species (ROS), mitochondrial deoxyribonucleic acid (mtDNA) mutations, telomere shortening, as well as other factors, contribute to the aging of the skin. In this overview, the issue of human skin aging is introduced, along with several pathways and the protective effects of ferulic acid in light of current patents. The complex antioxidant effect of ferulic acid depends on the “sweeping” away of free radicals as well as the suppression of the synthesis of ROS or nitrogen. Furthermore, Cu (II) or Fe protonated metal ions are chelated by this acid (II). Ferulic acid is a free radical scavenger as well as an enzyme inhibitor, increasing the activity of enzymes that scavenge free radicals while decreasing the activity of enzymes that speed up the creation of free radicals. AMPK signalling, which can regulate cellular homeostasis, stress tolerance, cell survival and proliferation, cell death, and autophagy, has recently been linked to aging and lifespan. Therefore, Caenorhabditis elegans (C. elegans) and rodents had longer life-spans due to specific AMPK activation. By inhibiting the TGF-β/Smad signalling pathway, UV irradiation can reduce the production of procollagen. Glycation changes the skin’s physical characteristics, making it less elastic and stiffer. . Excessive free radicals simultaneously trigger the nuclear factor kappa B (NF- κB) signalling pathway, increasing TNF levels and matrix metalloproteinase production (MMPs).

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“…Berberine reduced reactive oxygen species, malondialdehyde, and DNA damage and increased superoxide dismutase activity. Singh et al 9 showed that curcumin counteracts depolarization-induced glutamate release by reducing voltage-dependent Ca 2+ entry in rat nerve endings.…”

Section: Introductionmentioning

confidence: 99%

Walnut-Derived Peptides Ameliorate Scopolamine-Induced Memory Impairments in a Mouse Model via Activation of Peroxisome Proliferator-Activated Receptor γ-Mediated Excitotoxicity

Shen,

Dang,

Fang

et al. 2024

J. Agric. Food Chem.

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We investigated the protective effect of walnut peptides and YVPFPLP (YP-7) on scopolamine-induced memory impairment in mice and β-amyloid (Aβ)-induced excitotoxic injury in primary hippocampal neurons, respectively. Additionally, the protective mechanism of YP-7 on neuronal excitotoxicity was explored. Mouse behavioral and hippocampal slice morphology experiments indicate that YP-7 improves the learning and memory abilities of cognitively impaired mice and protects synaptic integrity. Immunofluorescence, western blotting, and electrophysiological experiments on primary hippocampal neurons indicate that YP-7 inhibits neuronal damage caused by excessive excitation of neurons induced by Aβ. HT-22 cell treatment with peroxisome proliferator-activated receptor γ (PPARγ) activators and inhibitors showed that YP-7 activates PPARγ expression and maintains normal neuronal function by forming stable complexes with PPARγ to inhibit the extracellular regulated protein kinase pathway. Therefore, YP-7 can ameliorate glutamate-induced excitotoxicity and maintain neuronal signaling. This provides a theoretical basis for active peptides to ameliorate excitotoxicity and the development of functional foods.

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Ferulic acid ameliorates neurodegeneration via the Nrf2/ARE signalling pathway: A Review

Cited by 18 publications

References 72 publications

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Ferulic Acid: Signaling Pathways in Aging

Walnut-Derived Peptides Ameliorate Scopolamine-Induced Memory Impairments in a Mouse Model via Activation of Peroxisome Proliferator-Activated Receptor γ-Mediated Excitotoxicity

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