Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies

Kański, Jarosław; Aksenova, Marina; Stoyanova, A.; Butterfield, D. Allan

doi:10.1016/s0955-2863(01)00215-7

Cited by 442 publications

(282 citation statements)

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“…The b-amyloid-and scopolamine-treated mice showed increased reaction times in a spatial memory test (water maze test), but the application of the T. aestivum extract reversed this effect. The total dietary fibre from T. aestivum L. effectively inhibited an Ab [25][26][27][28][29][30][31][32][33][34][35] -induced decrease in the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide. The authors concluded that the attenuation of the cytotoxicity and the memory deficits caused by scopolamine could be attributed to the presence of phenolic acids in T. aestivum L.…”

Section: Resultsmentioning

confidence: 99%

“…Ferulic acid exhibited neuroprotection towards striatal neuronal cells subjected to oxidized low-density lipoproteins (26). Vanillic, coumaric, cinnamic and, especially, ferulic acid inhibited the toxicity of 2,2'-azobis-2-methyl-propanimidamide (peroxyl radical initiator), reduced OH Á -induced oxidation of proteins and moderately decreased OH Á -induced oxidation of membrane lipids in the synaptosomes of cultured hippocampal neuronal cells (27). Also, ferulic acid almost completely attenuated protein crosslinking, oxidation and formation of protein carbonyls and free radical-induced alterations in cells (vacuolated soma and fragmented neurites) (27).…”

Section: Introductionmentioning

confidence: 99%

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Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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Anticholinesterase activities of mashes produced using wheat ('Wheat Pale') or barley malts ('Pilsner', 'Pale Ale', 'Munich Light', 'Carahell' or 'Carared') were studied by spectrophotometric method. The highest inhibition of acetylcholinesterase and butyrylcholinesterase was observed at 52 C and/or 64 C, followed by a decrease or stabilization of the activity at 72 C. Changes in the total phenolics content in the test mashes were correlated with changes in the acetylcholinesterase and/or butyrylcholinesterase activities. Phenolic acids were singled out from phenolic compounds for more detailed studies owing to their simplicity and structural similarity to well-known cholinesterase inhibitors. The main phenolic acids in the test malts were ferulic, gallic, p-coumaric and vanillic acids followed by chlorogenic, caffeic, syringic, p-OH-benzoic, sinapic and protocatechuic acids. The anticholinesterase activities of the phenolic acids were studied using model standard solutions at concentrations similar to the maximal content of these compounds in the test mashes. Among the phenolic acids, p-coumaric acid had the largest share in the anticholinesterase activity, even though it was present in the test mashes at a significantly lower concentration (~0.38 mM L À1 ) than ferulic acid (~1.00 mM L À1 ). Sinapic acid and p-OH-benzoic acid (0.03 and 0.01 mM L À1 , respectively) were equally efficient inhibitors as ferulic acid at~1.00 mM L À1 . This preliminary study should be extended to other phenolic compounds from malt (wort) in the near future.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Szwajgier

Borowiec

2012

J. Inst. Brew.

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“…In another study performed by Kanski et al (2002), the presence of FA in neuronal cell systems exposed to peroxyl and hydroxyl radicals reduced damage in the cells without causing its death, proving to be more potent than vanillic acid, coumaric acid and cinnamic acid. Analysis using the electron paramagnetic resonance technique in synaptosomal membrane proteins indicated that the protection provided by FA against free radicals is mediated by conformational changes in these proteins.…”

Section: Neuroprotective Agentmentioning

confidence: 96%

“…Additionally, this carboxylic acid group also acts as an anchor of FA by which it binds to the lipid bilayer, protecting against lipid peroxidation. In other words, the stable resonance structure of the phenoxy radical is responsible to cease propagation of any chain reaction initiated by free radicals, making FA especially able to scavenge and stop free radical chain reactions (Kanski et al, 2002;Graf, 1992). FA also presents "indirect" free radical scavenging activity, namely the ability of this phenolic acid to up-regulate the heme oxygenase-biliverdin reductase system (Calabrese et al, 2008;Barone et al, 2009; Fetoni et al, 2010), which in turn generates bilirubin, an endogenous free radical scavenger (Mancuso et al, 2006;Mancuso, Barone, 2009b).…”

mentioning

confidence: 99%

“…The production of free radicals and neuroinflammation contribute to the destruction of some brain regions such as the cortex (Mancuso et al, 2007). Thus, FA can have a favorable effect on AD due to its anti-inflammatory and antioxidant properties (Graf, 1992;Kanski et al, 2002). Ono et al (2005) evaluated the ability of FA to inhibit formation of β-amyloid fibrils (fAβ) and the destabilization of existing fibrils when compared with the results obtained in vitro in previous studies with curcumin, rifampicin and tetracycline.…”

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confidence: 99%

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Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Brenelli

Goldbeck

Santos

et al. 2013

Braz. J. Pharm. Sci.

162

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Ferulic acid is a phenolic acid widely distributed in the plant kingdom. It presents a wide range of potential therapeutic effects useful in the treatments of cancer, diabetes, lung and cardiovascular diseases, as well as hepatic, neuro and photoprotective effects and antimicrobial and anti-inflammatory activities. Overall, the pharmaceutical potential of ferulic acid can be attributed to its ability to scavenge free radicals. However, recent studies have revealed that ferulic acid presents pharmacological properties beyond those related to its antioxidant activity, such as the ability to competitively inhibit HMG-CoA reductase and activate glucokinase, contributing to reduce hypercholesterolemia and hyperglycemia, respectively. The present review addresses ferulic acid dietary sources, the pharmacokinetic profile, antioxidant action mechanisms and therapeutic effects in the treatment and prevention of various diseases, in order to provide a basis for understanding its mechanisms of action as well as its pharmaceutical potential.Uniterms: Ferulic acid/properties. Ferulic acid/antioxidant activity. Ferulic acid/dietary sources. Ferulic acid/therapeutic effects. Natural products. Pharmacognosy.O ácido ferúlico é um ácido fenólico amplamente distribuído no reino vegetal. Ele apresenta uma ampla gama de potenciais efeitos terapêuticos utéis no tratamento do câncer, diabetes, doenças pulmonares e cardiovasculares, bem como efeitos hepáticos, neuro e fotoprotetores, atividades antimicrobianas e antiinflamatórias. O potencial farmacêutico do ácido ferúlico pode ser atribuído à sua capacidade em sequestrar radicais livres. No entanto, estudos recentes revelaram que o ácido ferúlico apresenta propriedades farmacológicas, além da sua atividade antioxidante, como a capacidade de inibir competitivamente a HMG-CoA redutase e ativar a glucoquinase, contribuindo para reduzir a hipercolesterolemia e hiperglicemia, respectivamente. A presente revisão aborda as fontes dietéticas de ácido ferúlico, o perfil farmacocinético, os mecanismos de ação como antioxidante e efeitos terapêuticos no tratamento e prevenção de várias doenças, de modo a proporcionar uma base para a compreensão dos seus mecanismos de ação, bem como os seus potenciais farmacêuticos.Unitermos: Ácido ferúlico/propriedades. Ácido ferúlico/atividade antioxidante. Ácido ferúlico/fontes dietéticas. Ácido ferúlico/efeitos terapêuticos. Produtos naturais. Farmacognosia. INTRODUCTIONNatural antioxidants exhibit therapeutic potential for a variety of diseases such as cancer, diabetes, and cardiovascular and neurodegenerative diseases (Kayahara et al., 1999;Kim et al., 2003;Soobrattee et al., 2005) where free radicals play a key role in development (Prior et al., 1998). Recently there has been increased public and scientific interest in employing natural antioxidants instead of synthetic antioxidants, due to their potential adverse effects on health which may include carcinogenicity (Ito et al., 1983;Würtzen, 1990;Osawa et al., 1990).Antioxidants found in vegetables can ac...

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Whole Grain Phytochemicals and Antioxidant Activity

Liu¹,

Adom²

2007

Whole Grains and Health

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Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies

Cited by 442 publications

References 33 publications

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Phenolic acids from malt are efficient acetylcholinesterase and butyrylcholinesterase inhibitors

Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field

Whole Grain Phytochemicals and Antioxidant Activity

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