Ferulic acid in the treatment of post‐diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF‐<i>β</i>1, IL‐1<i>β</i> and Akt signalling

Roy, Subhas Chandra; Metya, Satyajit Kumar; Rahaman, Noorjaman; Sannigrahi, Santanu; Ahmed, Faiqa

doi:10.1002/cbf.2983

Cited by 50 publications

(33 citation statements)

References 44 publications

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“…31 TGF-β1 is observed in the round spermatids and Leydig cells of matured mouse testes over 50 days of age. 33 In the current study, HS significantly increased the gene expression of TGF-β1 in the testes, but curcumin significantly reduced the mRNA level of TGF-β1 overexpressed by HS. 33 In the current study, HS significantly increased the gene expression of TGF-β1 in the testes, but curcumin significantly reduced the mRNA level of TGF-β1 overexpressed by HS.…”

Section: Discussionmentioning

confidence: 40%

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

et al. 2015

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Approximately 20% of couples worldwide are infertile and about half of these couples have male infertility. Therefore, it is important to develop effective strategies for preventing male infertility. In this study, we examined the effects and regulatory mechanisms of curcumin, an active ingredient in the traditional herbal treatment derived from the dietary spice turmeric (Curcuma longa), on exogenous scrotal heat stress-induced testicular injuries in mice. Adult mice were orally administered three different doses of curcumin (20, 40, or 80 mg per kg per day) for 14 consecutive days and then subjected to transient scrotal heat stress at 43 °C for 20 min on day 7. The testes and blood of the mice were collected on day 14. Mice exposed to heat stress showed low testicular weight, severe vacuolization of seminiferous tubules followed by loss of spermatogenic cells, and the appearance of multinucleated giant cells and degenerative Leydig cells. In addition, great changes in oxidative stress (lipid peroxidation, superoxide dismutase (SOD) activity, cytoplasmic SOD, mitochondrial SOD, and phospholipid hydroperoxide glutathione peroxidase mRNAs), apoptosis (B-cell lymphoma-extra large and caspase 3 mRNAs), heat shock reaction (heat shock transcription factor-1 and transforming growth factor-β1 mRNAs) and androgen biosynthesis (testosterone concentration and 3β-hydroxysteroid dehydrogenase mRNA) were observed. However, all these testicular injuries induced by the scrotal hyperthermia were significantly improved by curcumin treatment (20, 40 and 80 mg kg(-1)) in a dose-dependent manner via its antioxidative, anti-apoptotic and androgen synthesis effects, indicating that it has the potential to prevent male infertility.

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Section: Discussionmentioning

confidence: 40%

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

et al. 2015

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“…Blood metabolite concentrations were within reference ranges (Kaneko et al, 2008), suggesting that ewes used had an adequate health status. In fact, in diabetic rats with high oxidative stress, Yoo et al (2012) and Roy et al (2014) reported that FA supplementation improved oxidative status while blood glucose and insulin concentrations returned to normal levels. This situation can lead to health problems in sheep and also provoke metabolic changes that reflect in imbalances of blood metabolite levels (Drackley, 1999).…”

Section: Discussionmentioning

confidence: 99%

“…Naturally, the FA is covalently linked to lignin and polysaccharides by ester and ether bonds, and thereby provides rigidity, strength, and protection from attack of microorganisms to plants (Kroon and Williamson, 1999). Furthermore, in its free form, FA is characterized as a bioactive compound that provides antioxidant properties for animals (Gladine et al, 2007;Roy et al, 2014) and humans (Manach et al, 2004;Ou and Kwok, 2004), and recent studies reported that also acts as a growth promoter in beef cattle (González-Ríos et al, 2013) and pigs (Herrera et al, 2011). In fact, compared with other natural antioxidant, this metabolite has proved be more effective to prevent lipid and protein oxidation (Rose et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Effects of free ferulic acid on productive performance, blood metabolites, and carcass characteristics of feedlot finishing ewe lambs

Macías‐Cruz

Perard

Vicente

et al. 2014

Journal of Animal Science

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The aim of this study was to evaluate effects of free ferulic acid (FA) supplementation on productive performance, some blood metabolite concentrations, and carcass characteristics of ewe lambs finished in a feedlot. Dorper×Pelibuey ewe lambs (n=20; BW=28.5±0.5 kg; age=5 mo) were individually housed in pens and assigned under a randomized complete block design to the following dietary treatments (n=10): daily feeding without (control) or with 300 mg of FA/animal. The feedlot feeding period lasted 34 d and then all ewe lambs were slaughtered. Free FA did not affect (P≥0.16) BW gain, ADG, DMI, and G:F during the first 17 d, but BW gain (P=0.10) and ADG (P=0.10) tended to decrease for FA from d 17 to 34 and from d 1 to 34 without affecting (P≥0.16) DMI and G:F in ewe lambs. Serum concentrations of glucose, cholesterol, triglyceride, total protein, and urea were not affected (P>0.05) by FA at d 1, 17, and 34 of the feeding period. Carcass characteristics were not affected (P>0.05) by FA. Stomach percentage tended (P=0.08) to decrease and leg yields increased (P=0.02) for FA. Other noncarcass components and wholesale cut yields were not affected (P>0.10) by FA. In conclusion, FA supplementation did not improve productive performance, metabolic status, and carcass characteristics of ewe lambs receiving a feedlot finishing diet.

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“…The most frequent effects of DM on the male reproductive system include decreased levels of testosterone, lower testicular weight, abnormal spermatogenesis, alterations in sperm count and motility, and histopathological changes in testis tissue components [2][3][4][5] . Abnormalities in spermatogenesis due to increased apoptosis have been demonstrated in certain studies 2,3,[6][7][8][9][10] . Testicular apoptosis may be the major component of the infertility.…”

Section: Introductionmentioning

confidence: 99%

MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

2014

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PURPOSE:To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes. METHODS:Twenty males Sprague-Dawley rats were randomly divided into a control group (n=8) and a diabetes group (administration of 40 mg/kg/day streptozotocin (STZ) for five sequential days, n=12). After six weeks, testicular biopsy samples were obtained for light microscopy and immunohistochemical methods. RESULTS:The PCNA (proliferating cell nuclear antigen) index was significantly decreased in the diabetes group (p=0.004) when compared to the control group. Both total (t)-ERK and phosphor (p)-ERK immunoreactivities were significantly decreased in the diabetes group (p=0.004, p<0.001, respectively). The t-JNK immunoreactivity was unchanged in both groups (p=0.125), while p-JNK immunoreactivity was significantly increased in the diabetic group (p=0.002). CONCLUSIONS:The decrease of androgen levels in the course of diabetes may contribute to the decrease of the immunoreactivities of t-ERK and p-ERK. JNK may be activated due to the changes in various cytokines and chemochines that participate in the oxidative stress process of diabetes. Therefore, testicular apoptosis may occur and lead to infertility associated with diabetes.

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Ferulic acid in the treatment of post‐diabetes testicular damage: relevance to the down regulation of apoptosis correlates with antioxidant status via modulation of TGF‐β1, IL‐1β and Akt signalling

Cited by 50 publications

References 44 publications

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice

Effects of free ferulic acid on productive performance, blood metabolites, and carcass characteristics of feedlot finishing ewe lambs

MAPK immunoreactivity in streptozotocin-induced diabetic rat testis

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