FET-Based Integrated Charge Sensor for Organ-on-Chip Applications

Aydogmus, Hande; Dostanic, Milica; Jahangiri, Mojtaba; Sinha, Rajarshi; Quiros-Solano, William F.; Mastrangeli, Massimo; Sarro, P.M.

doi:10.1109/sensors47125.2020.9278692

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…In this regard, polyimide (PI) layers can be interposed, both to improve metal adhesion upon oxygen plasma surface activation on PDMS and as stress buffer to match the higher mechanical stiffness of metals. The latter can avoid deleterious consequences such as wrinkling and warpage [85][86]. PI can be formulated as adhesive in tape form (commercially known as Kapton), besides as photo-patternable photoresist.…”

Section: B Polymersmentioning

confidence: 99%

Technology Development for MEMS: A Tutorial

et al. 2022

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Silicon sensors date back to before 1960 with early Hall and piezoresistive devices. These used simple processing that was part of the early integrated circuit (IC) industry. As the IC industry developed, silicon sensors could benefit from the technological advances. As silicon sensors advanced, there came the need for new technologies specifically for microsystems. This led to a range of 3-D structures using micromachining and enabled the development of both sensors and actuators. The integration of sensors with electronics on a single chip also presented new challenges to ensure that both sensor and electronics would function correctly at the end of the processing. In recent years many new technologies and new materials were introduced to enhance the functionality of microsystems. Some sensors are still based on silicon, but others introduce new materials such as carbon nanotubes and graphene. Technologies that have been used in other applications for many years are now integral part of the microsystem technology portfolio. These include screen printing and inkjet printing. Moving more into the third dimension, 3-D printing presents many new opportunities to fabricate novel structures on a silicon substrate. This tutorial focuses on the additional technologies which have been developed to supplement standard IC processes to create MEMS structures.

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Section: B Polymersmentioning

confidence: 99%

Technology Development for MEMS: A Tutorial

et al. 2022

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“…For example, universal open-source potentiostats for assays have been reported, such as USB connected DStat [51] or Bluetooth operated Universal Wireless Electrochemical Detector (UWED) [52], which both have material cost below 100 EUR, and can support most common EC techniques, such as potentiometric measurements, CA, CV, SWV, and DPV. Further miniaturization is possible by direct CMOS integration of control electronics directly with organ chip devices [53].…”

Section: Integration Of Electrochemical Sensingmentioning

confidence: 99%

Electrochemical Sensing in 3D Cell Culture Models: New Tools for Developing Better Cancer Diagnostics and Treatments

Oliveira

Conceição

Kant

et al. 2021

Cancers

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Currently, conventional pre-clinical in vitro studies are primarily based on two-dimensional (2D) cell culture models, which are usually limited in mimicking the real three-dimensional (3D) physiological conditions, cell heterogeneity, cell to cell interaction, and extracellular matrix (ECM) present in living tissues. Traditionally, animal models are used to mimic the 3D environment of tissues and organs, but they suffer from high costs, are time consuming, bring up ethical concerns, and still present many differences when compared to the human body. The applications of microfluidic-based 3D cell culture models are advantageous and useful as they include 3D multicellular model systems (MCMS). These models have demonstrated potential to simulate the in vivo 3D microenvironment with relatively low cost and high throughput. The incorporation of monitoring capabilities in the MCMS has also been explored to evaluate in real time biophysical and chemical parameters of the system, for example temperature, oxygen, pH, and metabolites. Electrochemical sensing is considered as one of the most sensitive and commercially adapted technologies for bio-sensing applications. Amalgamation of electrochemical biosensing with cell culture in microfluidic devices with improved sensitivity and performance are the future of 3D systems. Particularly in cancer, such models with integrated sensing capabilities can be crucial to assess the multiple parameters involved in tumour formation, proliferation, and invasion. In this review, we are focusing on existing 3D cell culture systems with integrated electrochemical sensing for potential applications in cancer models to advance diagnosis and treatment. We discuss their design, sensing principle, and application in the biomedical area to understand the potential relevance of miniaturized electrochemical hybrid systems for the next generation of diagnostic platforms for precision medicine.

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“…In this regard, we have demonstrated the integration of electrochemical charge microsensors within a MEM OoC device [33]. The 1-by-1 cm 2 OoC device is composed by a rigid silicon frame supporting a soft and optically transparent polymer membrane, and is fabricated by a largely CMOS-compatible process flow (Fig.…”

Section: Sensing: Integrated Fet-based Charge Sensormentioning

confidence: 99%

Microelectromechanical Organs-on-Chip

Mastrangeli

Aydogmus

Dostanic

et al. 2021

2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)

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Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap in drug development, and possibly foster personalized medicine. Here we underline the biotechnological convergence at the root of OoC technology, and outline research tracks under development in our group at TU Delft along two main directions: fabrication of innovative microelectromechanical OoC devices, integrating stimulation and sensing of tissue activity, and their embedding within advanced platforms for pre-clinical research. We conclude with remarks on the role of open technology platforms for the broader establishment of OoC technology in pre-clinical research and drug development.

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FET-Based Integrated Charge Sensor for Organ-on-Chip Applications

Cited by 5 publications

References 20 publications

Technology Development for MEMS: A Tutorial

Technology Development for MEMS: A Tutorial

Electrochemical Sensing in 3D Cell Culture Models: New Tools for Developing Better Cancer Diagnostics and Treatments

Microelectromechanical Organs-on-Chip

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