Fetal anemia as a signal of congenital syphilis

Macé, G.; Castaigne, Vanina; Trabbia, Aurore; Guigue, Virginie; Cynober, Evelyne; Cortey, A.; Lalande, V.; Carbonne, Bruno

doi:10.3109/14767058.2013.853288

Cited by 11 publications

(18 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rarely, fetal anemia and hydrops can be caused by other congenital infections, including cytomegalovirus (CMV), syphilis and toxoplasmosis. Other ultrasonographic features of congenital infections may include ascites, placentomegaly, hepatosplenomegaly, echogenic bowel, liver or intracranial calcifications, ventriculomegaly and intrauterine growth restriction (IUGR).…”

Section: Introductionmentioning

confidence: 99%

Fetal anemia

Abbasi

Johnson

Ryan

2017

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Fetal anemia

Abbasi

Johnson

Ryan

2017

Ultrasound in Obstet & Gyne

View full text Add to dashboard Cite

“…Placental enlargement and pallor may indicate fetal anemia progressing to hydrops. One feature strongly associated with stillbirth in congenital syphilis is normoblastemia, consistent with fetal anemia ..…”

Section: Part II the Histopathology Of Placental Infectionmentioning

confidence: 90%

Defense and infection of the human placenta

Heerema-McKenney

2018

APMIS

View full text Add to dashboard Cite

The placenta functions as a shield against infection of the fetus. The innate and adaptive immune defenses of the developing fetus are poorly equipped to fight infections. Infection by bacteria, viruses, and protozoa may cause infertility, spontaneous abortion, stillbirth, growth retardation, anomalies of development, premature delivery, neonatal morbidity, and mortality. However, appreciation of the human microbiome and host cell-microbe interactions must be taken into consideration as we try to determine what interactions are pathologic. Infection is typically recognized histologically by the presence of inflammation. Yet, several factors make comparison of the placenta to other human organs difficult. The placenta comprises tissues from two persons, complicating the role of the immune system. The placenta is a temporary organ. It must be eventually expelled; the processes leading to partuition involve maternal inflammation. What is normal or pathologic may be a function of timing or extent of the process. We now must consider whether bacteria, and even some viruses, are useful commensals or pathogens. Still, recognizing infection of the placenta is one of the most important contributions placental pathologic examination can give to care of the mother and neonate. This review provides a brief overview of placental defense against infection, consideration of the placental microbiome, routes of infection, and the histopathology of amniotic fluid infection and TORCH infections.

show abstract

“…Only few case reports (n = 12) document fetal hydrops secondary to congenital syphilis [16,17,18,19,20,21,22], and fewer used intrauterine transfusion as a treatment [18,20,22]. The median age of those women was 21 years and 40% were nulliparous.…”

Section: Discussionmentioning

confidence: 99%

Syphilis Infection: An Uncommon Etiology of Infectious Nonimmune Fetal Hydrops with Anemia

Fuchs

Michaux²,

Rousseau

et al. 2014

Fetal Diagn Ther

View full text Add to dashboard Cite

An increased prevalence of syphilis has been observed in many developed countries over the last decade. During pregnancy, syphilis can affect the fetus through development of nonspecific symptoms such as microcephaly, ascites, hepatosplenomegaly, dilated and echogenic bowel, placentomegaly, and, uncommonly, fetal hydrops. Congenital syphilis also leads to hematologic abnormalities such as anemia, thrombocytopenia, leukopenia, and leukocytosis. We present a case of nonimmune fetal hydrops with anemia related to syphilis infection. Diagnosis was confirmed by a maternal serological test and microbiological testing on amniotic fluid, umbilical cord, and placental tissues. The patient was treated with penicillin and the fetus received an intrauterine red blood cell transfusion, but fetal death occurred shortly after. Such a presentation is mostly related to parvovirus B19, and syphilis etiology is poorly mentioned because physicians have rarely seen early congenital syphilis in the past. However, given the increasing prevalence of this disease in the adult population, clinicians should remain alert to the various presentations of congenital syphilis.

show abstract

Fetal anemia as a signal of congenital syphilis

Cited by 11 publications

References 8 publications

Fetal anemia

Fetal anemia

Defense and infection of the human placenta

Syphilis Infection: An Uncommon Etiology of Infectious Nonimmune Fetal Hydrops with Anemia

Contact Info

Product

Resources

About