2000
DOI: 10.1007/s11745-000-0602-2
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Fetal erythrocyte phospholipid polyunsaturated fatty acids are altered in pregnancy complicated with gestational diabetes mellitus

Abstract: Insulin resistance and altered maternal metabolism in gestational diabetes mellitus (GDM) may impair fetal arachidonic acid (AA) and docosahexaenoic acid (DHA) status. The objectives were to test the hypothesis that fetal polyunsaturated fatty acids would be altered with GDM and identify factors related to fetal phospholipid (PL) AA and DHA. Maternal and cord vein erythrocyte PL fatty acids were determined in GDM (n = 13) and healthy pregnant women (controls, n = 12). Cord vein erythrocyte PL AA and DHA concen… Show more

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Cited by 92 publications
(54 citation statements)
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“…This causes even more successful competition of de novo synthesized OA for delta-6 desaturase and the occurrence of a state of 'relative EFA/LCP deficiency', rather than an absolute deficiency [25]. Such conditions have been encountered in maternal diabetes mellitus type 2, gestational diabetes [25,26] and preeclampsia [27], which may carry a common denominator in maternal insulin resistance. The underlying mechanisms might be higher transplacental glucose flux with concomitantly increased fetal de novo fatty acid synthesis in (gestational) diabetes, and highly increased de novo fatty acid synthesis in the maternal liver [28] with subsequent presentation of these fatty acids for transplacental transfer in (gestational) diabetes and preeclampsia.…”
Section: Discussionmentioning
confidence: 99%
“…This causes even more successful competition of de novo synthesized OA for delta-6 desaturase and the occurrence of a state of 'relative EFA/LCP deficiency', rather than an absolute deficiency [25]. Such conditions have been encountered in maternal diabetes mellitus type 2, gestational diabetes [25,26] and preeclampsia [27], which may carry a common denominator in maternal insulin resistance. The underlying mechanisms might be higher transplacental glucose flux with concomitantly increased fetal de novo fatty acid synthesis in (gestational) diabetes, and highly increased de novo fatty acid synthesis in the maternal liver [28] with subsequent presentation of these fatty acids for transplacental transfer in (gestational) diabetes and preeclampsia.…”
Section: Discussionmentioning
confidence: 99%
“…It is known that children born to women with gestational diabetes mellitus (GDM) have a higher incidence of diabetes. Wijendran et al (2000) reported that umbilical cord vein erythrocyte phospholipid AA and DHA concentrations were significantly lower in women with GDM in comparison to healthy pregnant women. Maternal HbA 1c (glycosylated hemoglobin) was inversely correlated to fetal erythrocyte phospholipid DHA and AA in GDM.…”
Section: Conclusion and Therapeutic Implicationsmentioning
confidence: 98%
“…This is surprising since the disorder is characterised by insulin resistance, inability to increase output of insulin (Bowes et al, 1996), impaired glucose transport and insulin receptor autophosphorylation (Friedman et al, 1999;Yamashita et al, 2000) and vascular endothelial dysfunction (Knock et al, 1997). Abnormalities of plasma (Wijendran et al, 1999) and red cell (Wijendran et al, 2000) fatty acids have been reported in diettreated GDM women. Similarly, we have recently found lower levels of AA and DHA in red cell choline phosphoglycerides of newly diagnosed gestational diabetics (Min et al, 2004).…”
Section: Introductionmentioning
confidence: 99%