Fetal growth retardation in rats may result from apoptosis: Role of peroxynitrite

Miller, Mark J.S.; Voelker, Cynthia A; Olister, Staci M; Thompson, Jane H.; Zhang, X.-J.; Rivera, Dana L; Eloby-Childress, Sandra; Liu, X.; Clark, David A.; Pierce, Maria R.

doi:10.1016/0891-5849(96)00171-2

Cited by 63 publications

(33 citation statements)

References 28 publications

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“…When we looked at previous studies that investigated the effects of various medications administered during the fetal period, we found that non-steroidal anti-inflammatory drugs at toxic doses caused intrauterine growth retardation (32,33) and nitric oxide synthase inhibitors resulted in fetal growth retardation by uteroplacental dysfunction (34,35). Further, Ishida et al (36) reported that DL-alpha-difluoromethyl orni- (9) f (10) m (2) f (5) m (20) f (13) m (9) f (10) m (2) f (5) m (20) f (13) m (9) f (10) m (2) f (5) m (20) f (13) Table 1c.…”

Section: Discussionmentioning

confidence: 99%

Effects Of Dimenhydrinate And Ondansetron Used In Pregnant Rats On Postnatal Morphometric Development

Desdicioğlu¹,

Cankara²,

Evcil³

et al. 2009

TUTFD

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Section: Discussionmentioning

confidence: 99%

Effects Of Dimenhydrinate And Ondansetron Used In Pregnant Rats On Postnatal Morphometric Development

Desdicioğlu¹,

Cankara²,

Evcil³

et al. 2009

TUTFD

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“…Â 4-þ ãðóïïó âîøëè aeèâîòíûå ñ ÍÌÏÊ, äîïîëíèòåëüíî ïî-ëó÷àâøèå ñ 1-ãî äíÿ áåðåìåííîñòè âìåñòî ïèòüåâîé âîäû äîíàòîð îêèñè àçîòà 0,2 % ðàñòâîð íèòðèòà íà-òðèÿ [15]. Êðûñû ñ ÍÌÏÊ è ââåäåíèåì íåñåëåêòèâíî-ãî èíãèáèòîðà ñèíòåçà îêèñè àçîòà ìåòèëîâîãî ýôèðà L-àðãèíèíà (L-NAME) (Sigma) âíóòðèìûøå÷íî â äîçå 10 ìã/êã [12] ñ 1 äíÿ áåðåìåííîñòè ñîñòàâèëè 5-þ ãðóïïó.…”

Section: ìåòîäû èññëåäîâàíèßunclassified

Влияние Оксида Азота И Альфа-Токоферола На Структурные Изменения В Плаценте При Нарушении Маточно-Плацентарного Кровообращения У Белых Крыс

Иванова¹,

Перетятко²,

Демидов³

et al. 2015

Эксп. и клин. фармакол.

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Öåëü ðàáîòû -èçó÷åíèå âëèÿíèÿ îêñèäà àçîòà è àëüôà-òîêîôåðîëà íà ìîðôîëîãè-÷åñêèå èçìåíåíèÿ â ïëàöåíòå áåëûõ êðûñ ïðè áåðåìåííîñòè, îñëîaeíåííîé íàðóøåíè-ÿìè ìàòî÷íîãî è ïëàöåíòàðíîãî êðîâîîáðàùåíèÿ. Íàðóøåíèå ìàòî÷íî-ïëàöåíòàðíîãî êðîâîîáðàùåíèÿ îñóùåñòâëÿëè ïî ìåòîäèêå [2]. Ïðè íàðóøåíèè ìàòî÷íî-ïëàöåíòàð-íîãî êðîâîñíàáaeåíèÿ ó áåëûõ êðûñ èñïîëüçîâàíèå ìåòèëîâîãî ýôèðà L-àðãèíèíà êîì-ïåíñèðóåò íàðóøåíèÿ ñî ñòîðîíû ôåòîïëàöåíòàðíîãî êðîâîòîêà. Óâåëè÷åíèå îêñèäà àçîòà è òîðìîaeåíèå ñâîáîäíîðàäèêàëüíûõ ïðîöåññîâ â ïëàöåíòå ýêñïåðèìåíòàëüíûõ aeèâîòíûõ â óñëîâèÿõ èñêóññòâåííî ñîçäàííîé ïàòîëîãèè áåðåìåííîñòè îòíîñÿòñÿ íå ê ñàíîãåíåòè÷åñêèì, à ê ïàòîãåíåòè÷åñêèì ôàêòîðàì.Êëþ÷åâûå ñëîâà: ôåòîïëàöåíòàðíàÿ íåäîñòàòî÷íîñòü; îêñèä àçîòà; àëüôà-òîêîôåðîë; ïëàöåíòà. ÂÂÅÄÅÍÈÅÏëàöåíòà ïðîäóöèðóåò áîëüøîå êîëè÷åñòâî áèîëî-ãè÷åñêè àêòèâíûõ âåùåñòâ, ðåãóëèðóþùèõ ãåìîöèðêó-ëÿöèþ â ôåòîïëàöåíòàðíîé îáëàñòè, äèôôåðåíöèðîâ-êó è ðàçâèòèå òðîôîáëàñòà, ïðîöåññû àïîïòîçà â êëåò-êàõ, à òàêaeå ìîäóëèðóþùèõ ñåêðåöèþ ãîðìîíîâ [9]. Îäíèì èç òàêèõ ñîåäèíåíèé ÿâëÿåòñÿ îêñèä àçîòà [16]. Àêòèâíîñòü NO-çàâèñèìûõ ïðîöåññîâ ÿâëÿåòñÿ âàae-íûì ïàòîãåíåòè÷åñêèì è ñàíîãåíåòè÷åñêèì ôàêòîðîì ïðè ðàçâèòèè ôåòîïëàöåíòàðíîé íåäîñòàòî÷íîñòè [3]. Âåùåñòâà, ÿâëÿþùèåñÿ äîíàòîðàìè èëè ïðåäøåñòâåí-íèêàìè îêñèäà àçîòà, ïî äàííûì íåêîòîðûõ èññëåäîâà-íèé [9], îêàçûâàþò ïîëîaeèòåëüíîå âëèÿíèå íà òå÷åíèå áåðåìåííîñòè è ðàçâèòèå ïëîäà. Ïîçèòèâíîå âëèÿíèå äîíàòîðîâ îêñèäà àçîòà íà ñèñòåìó "ìàòü -ïëàöåíòà -ïëîä" ÿâèëîñü ïîâîäîì äëÿ âêëþ÷åíèÿ ýòèõ âåùåñòâ â òåðàïèþ ïëàöåíòàðíîé íåäîñòàòî÷íîñòè [1]. Îäíàêî ïîëó÷åííûå ðåçóëüòàòû íîñÿò ïðîòèâîðå÷èâûé õàðàê-òåð è òðåáóþò äàëüíåéøåãî èçó÷åíèÿ ðîëè ïðåäøåñò-âåííèêîâ îêñèäà àçîòà â ôîðìèðîâàíèè êîìïåíñàòîð-íûõ ïðîöåññîâ â ïëàöåíòå ïðè íàðóøåíèÿõ ìàòî÷íîãî è ïëàöåíòàðíîãî êðîâîîáðàùåíèÿ.Èçâåñòíî, ÷òî ôåòîïëàöåíòàðíàÿ íåäîñòàòî÷íîñòü ñîïðîâîaeäàåòñÿ èçìåíåíèåì áàëàíñà ñâîáîäíûõ ðàäè-êàëîâ è àíòèîêñèäàíòîâ. Ïî äàííûì ëèòåðàòóðû [11], ñâîåâðåìåííàÿ êîððåêöèÿ äèñáàëàíñà îêàçûâàåò ïîëî-aeèòåëüíîå âëèÿíèå íà òå÷åíèå áåðåìåííîñòè, ðàçâè-òèå ïëîäà è íîâîðîaeäåííîãî.Öåëü ðàáîòû -èçó÷åíèå âëèÿíèÿ îêñèäà àçîòà è àëüôà-òîêîôåðîëà íà ìîðôîëîãè÷åñêèå èçìåíåíèÿ â ïëàöåíòå áåëûõ êðûñ ïðè áåðåìåííîñòè, îñëîaeíåííîé íàðóøåíèåì ìàòî÷íî-ïëàöåíòàðíîãî êðîâîîáðàùåíèÿ. ÌÅÒÎÄÛ ÈÑÑËÅÄÎÂÀÍÈßÈññëåäîâàíèå ïðîâîäèëè íà 60 ïëàöåíòàõ áåëûõ áåñïîðîäíûõ êðûñ-ñàìîê. Âûáîð êðûñ êàê îáúåêòà èñ-ñëåäîâàíèé îáóñëîâëåí òåì, ÷òî, ïîäîáíî ÷åëîâåêó, aeèâîòíûå èìåþò ãåìîõîðèàëüíûé òèï ïëàöåíòû, ÷òî èìååò îïðåäåëåííîå çíà÷åíèå äëÿ èíòåðïðåòàöèè ïî-ëó÷åííûõ äàííûõ è èõ ýêñòðàïîëÿöèè íà ÷åëîâåêà. Ïåðâûé äåíü áåðåìåííîñòè ðåãèñòðèðîâàëè ïî ïîÿâ-ëåíèþ ñïåðìàòîçîèäîâ âî âëàãàëèùíûõ ìàçêàõ. Ôåòî-ïëàöåíòàðíóþ íåäîñòàòî÷íîñòü ìîäåëèðîâàëè íàðó-øåíèåì ìàòî÷íî-ïëàöåíòàðíîãî êðîâîîáðàùåíèÿ [2] ïî ìåòîäèêå [2].Áåðåìåííûå êðûñû áûëè ðàçäåëåíû íà 6 ãðóïï ïî 10 îñîáåé â êàaeäîé: 1 -êðûñû ñ ôèçèîëîãè÷åñêèì òå÷åíèåì áåðåìåííîñòè (êîíòðîëü); 2 -aeèâîòíûå ñ ýêñïåðèìåíòàëüíûì íàðóøåíèåì ìàòî÷íî-ïëàöåíòàð-íîãî êðîâîîáðàùåíèÿ (ÍÌÏÊ); 3 -ëîaeíî îïåðèðî-âàííûå áåðåìåííûå êðûñû (ãðóïïà ñðàâíåíèÿ)....

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“…In the fetus exposed to an episode of ischemia, alteration of DNA can increase, in vivo, by a factor from 12 to 128 [25]. Despite active repair activities [19], some of the damaged DNA is subject to permanent alterations which can induce cellular apoptosis or tissue necrosis [26,27], fetal growth retardation [27], death of the embryo [28] or latent pathologies [29,30], some of which break out when the organism faces new disequilibria between ROS production and elimination, notably during postnatal life.…”

Section: Overview Of Radical Phenomenamentioning

confidence: 99%

“…ROS production in the pregnant woman or gestating laboratory animal A large set of factors can induce high steady rates of ROS (H 2 O 2 , O −• 2 and • NO) from the time of ovulation up to delivery: high rates of estrogens [14,31], cytokines, oncogenes and growth factor signaling [16], production by neutrophiles [8,32] or activation of membrane NADPH oxidases by contact between tissues from the embryo and mother [33]. High levels of • NO are also observed in the circulation of pregnant women [5,32] or gestating rats [27], notably produced by neutrophiles together with O −• 2 . ROS production by neutrophiles during gestation do not bear any relationship to their usual function, adherence, chemotaxis or phagocytosis [32].…”

Section: Ros Productionmentioning

confidence: 99%

“…ROS production by neutrophiles during gestation do not bear any relationship to their usual function, adherence, chemotaxis or phagocytosis [32]. The interaction of the two ROS is one of the sources of • OH and of peroxynitrite (ONOO − ) in the circulation of the gestating female [5,27]. In the rat, high rates of O −• 2 (decreasing steadily from gestational day 12 to reach a 60% lesser level on day 16), of H 2 O 2 (with an increase between days 12 and 14 and a 63% decrease between days 14 and 16) and of • OH (doubling between days 12 and 16) have also been recorded in ex vivo fetal homogenates [25].…”

Section: Ros Productionmentioning

confidence: 99%

See 1 more Smart Citation

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

2006

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-In mammals, radical oxygen species (ROS) are essential factors of cell replication, differentiation and growth (oxidative signal), notably during gestation, but are also potentially damaging agents. In Women, ROS play a role in remodeling of uterine tissues, implantation of the embryo, settlement of the villi and development of blood vessels characteristic of gestation. The body stores of vitamins and minerals of gestating females are used to keep ROS fluxes at a level corresponding to oxidative signals and to prevent an imbalance between their production and scavenging (oxidative stress), which would be detrimental to the mother and fetus. There is some evidence that, although based on different regulatory mechanisms, most of the effects of ROS reported in humans also occur in pregnant ruminant females, some of which have been actually reported. Many vitamins and trace elements have dual effects in the organism of mammals: (a) they are involved in the control of metabolic pathways or/and gene expression, (b) but most of the time they also display ROS trapping activity or their deficiencies induce high rates of ROS production. Deficiencies induce different disorders of gestation and can be induced by different kinds of stress. An example is given, corresponding to the decreased contents of cobalt of forages, when exposed to sustained heavy rains, so that the supply of vitamins B12 to the organism of the ruminant that grazes them is reduced and failure of gestation is induced. Outdoor exposure of ruminants to adverse climatic conditions by itself can increase the vitamin and trace element requirements. Adaptation of production systems taking into account these interactions between gestation and sources of stress or change of the quality of feeding stuffs as well as further developments of knowledge in that field is necessary to promote sustainable agricultural practices.gestation / ovine / bovine / vitamins / trace elements / antioxidant enzymes / radical oxygen species / radical phenomena

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Fetal growth retardation in rats may result from apoptosis: Role of peroxynitrite

Cited by 63 publications

References 28 publications

Effects Of Dimenhydrinate And Ondansetron Used In Pregnant Rats On Postnatal Morphometric Development

Effects Of Dimenhydrinate And Ondansetron Used In Pregnant Rats On Postnatal Morphometric Development

Влияние Оксида Азота И Альфа-Токоферола На Структурные Изменения В Плаценте При Нарушении Маточно-Плацентарного Кровообращения У Белых Крыс

Gestation linked radical oxygen species fluxes and vitamins and trace mineral deficiencies in the ruminant

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