Fetal Growth Retardation Produced by Experimental Placental Insufficiency in the Rhesus Monkey. I. Body Weight, Organ Size

Myers, Ronald E.; Hill, Donald E.; Holt, A B; Scott, Rachel; Mellits, E. David; Cheek, Donald B.

doi:10.1159/000240380

Cited by 65 publications

(30 citation statements)

References 8 publications

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“…This same pattern is also observed in animal stud ies in which either the uterine [13] or the umbilical [14] blood flows arc reduced. Thus, similar effects on organ weights can as well be produced by reducing blood flow through the placenta [ 15] as by rendering the mother her self hypoxic.…”

Section: Discussionsupporting

confidence: 75%

Fetal Growth Retardation in Rats from Different Levels of Hypoxia

Grauw

Myers

Scott³

1986

Neonatology

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Three groups of pregnant Wistar rats were subjected to 3 different levels of hypoxia: 11.6, 10.7 and 9.0%, respectively. Pair-fed and ad libitum fed control groups were included to control for the reduced food intake due to hypoxia. Within the range studied, fetal body weights decreased with decreased oxygen availability. Liver weights were more, brain weights less markedly reduced than body weights. Pair-fed but normally oxygenated animals showed slight reductions in body and organ weights compared to ad libitum fed controls. The fetuses subjected to hypoxia showed a placental hypertrophy relative to their body weights, while the least hypoxic fetuses showed an absolute placental hypertrophy. Placenta-fetal body ratios that were 150% greater than those observed in control animals were documented. In contrast, the fetuses of food-deprived animals were associated with abnormally small placentas.

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Section: Discussionsupporting

confidence: 75%

Fetal Growth Retardation in Rats from Different Levels of Hypoxia

Grauw

Myers

Scott³

1986

Neonatology

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“…The same results were seen in rabbits by Harding (10). From these results we can conclude that the brain is protected from gross damage due to intrauterine malnutrition (10,13,16,22,23). Wet weight and dry weight of the brain are significantly lower at birth in preterm rats.…”

Section: Discussionsupporting

confidence: 71%

The Postnatal Development of Rats Born Preterm and Postterm

Bührdel¹,

Keller²,

Willgerodt³

et al. 1978

Neonatology

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Groups of 3 preterm (duration of gestation 22 days), 3 term (23 days), and 3 postterm (24 days) rats have been fed together by 1 mother rat. The postnatal growth of liver, brain, heart and kidney has been studied up to the 30th day of life. The postnatal loss of water shows good correlation with the maturation of each organ. The postnatal loss of water is marked in brain and kidneys, but only slight in liver and heart. The pronounced growth spurt of the brain at the about 10th day of life is probably due to the opening of the eyes. The growth spurt of the liver at the 15th day may be due to the supplementary food at the time of weaning. The effect of intrauterine undernutrition in postterm rats is most strikingly demonstrated in the liver. Postnatal undernutrition in preterm rats causes a retardation of growth of the liver and kidneys.

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“…In that study the weight distribution of the fetuses in which uteroplacental blood flow was limited demonstrated a striking pattern of growth restriction when compared to controls. Other investigators such as Meyers et al [9] and Creasy et al [12] have demonstrated severe growth restriction by similar methods. However, in all these studies, oxygen and nutrient supply to the fetus is limited; whereas, in our study, only oxygen is limited and is the cause of growth restriction.…”

Section: Discussionmentioning

confidence: 74%

Brief, Intermittent Hypoxia Restricts Fetal Growth in Sprague-Dawley Rats

et al. 1998

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This study was conducted to determine whether brief, intermittent exposure to hypoxia with little change in nutrient intake would affect fetal growth. Pregnant rats were exposed to 1 or 2 h of hypoxia (FiO₂ = 0.09–0.095) from days 15 to 19 of gestation. Exposure to 1 h of hypoxia decreased fetal body weight and length, liver weight and increased the brain/liver weight ratio (p < 0.05) as compared to controls. Two hours of hypoxia decreased fetal body weight and length, and heart, lung, kidney, gut, brain and liver weights (p < 0.01), but did not affect the brain/liver weight ratio. Two hours of hypoxia decreased maternal food intake and weight gain (p < 0.05), but fetal growth was not significantly altered in pair-fed controls. These data demonstrate that brief, intermittent periods of intrauterine hypoxia have significant effects on fetal growth.

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Fetal Growth Retardation Produced by Experimental Placental Insufficiency in the Rhesus Monkey. I. Body Weight, Organ Size

Cited by 65 publications

References 8 publications

Fetal Growth Retardation in Rats from Different Levels of Hypoxia

Fetal Growth Retardation in Rats from Different Levels of Hypoxia

The Postnatal Development of Rats Born Preterm and Postterm

Brief, Intermittent Hypoxia Restricts Fetal Growth in Sprague-Dawley Rats

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