Fetal growth trajectory and risk for eczema in a Saudi population

AlMakoshi, Amel; Ellahi, Awaiss; Sallout, Bala; Devereux, Graham; Turner, Steve

doi:10.1111/pai.12380

Cited by 9 publications

(14 citation statements)

References 19 publications

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“…Accelerated growth and a relative increase in abdominal circumference between the first and second trimesters of pregnancy were associated with a higher risk for AD . Conversely, a Saudi Arabian birth cohort study found that decreased fetal abdominal circumference was linked to AD in the first 2 years . These contrasting findings suggest a potential link between fetal growth trajectory during the second half of pregnancy and the development of allergy.…”

Section: Prenatal Risk Factorsmentioning

confidence: 95%

“…18 Conversely, a Saudi Arabian birth cohort study found that decreased fetal abdominal circumference was linked to AD in the first 2 years. 19 These contrasting findings suggest a potential link between fetal growth trajectory during the second half of pregnancy and the development of allergy. A likely reason may be the maternal obesity that represents a key factor for the modulation of neonatal immune system development.…”

Section: Prenatal Risk Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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The rising burden of allergic diseases in childhood requires a compelling need to identify individuals at risk for atopy very early in life or even predict the onset of food allergy and atopic dermatitis since pregnancy. The development and clinical phenotypes of atopic diseases in childhood depend on a complex interaction between genetic and environmental factors, such as allergen exposure, air pollution, and infections. Preventive strategies may include avoidance measures, diet supplements, and early complementary food introduction. Overall, the management of allergic diseases has been improving to date toward a patient's tailored approach. This review will cover the current understanding of risk factors, prediction, and management of food allergy and atopic dermatitis in childhood and discuss how these may contribute to the modification of the natural history of food allergy and atopic dermatitis.

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Section: Prenatal Risk Factorsmentioning

confidence: 95%

Section: Prenatal Risk Factorsmentioning

confidence: 99%

Food allergy and atopic dermatitis: Prediction, progression, and prevention

Mastrorilli

Caffarelli

Hoffmann‐Sommergruber

2017

Pediatric Allergy Immunology

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“…Maternal, fetal, or neonatal deaths were examined in 12 cohort studies [25,26,62,63,68,82,85,87,90,93,112]. Eczema in children at 2 years of age was assessed in only one cohort in Saudi Arabia that linked to the sub-optimal growth indexed by fetal abdominal circumference [69] (see Additional file 3: Table S2).…”

Section: Other Exposuresmentioning

confidence: 99%

Maternal and birth cohort studies in the Gulf Cooperation Council countries: a systematic review and meta-analysis

et al. 2020

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Background: We systematically reviewed and chronicled exposures and outcomes measured in the maternal and birth cohort studies in the Gulf Cooperation Council (GCC) countries and quantitatively summarized the weighted effect estimates between maternal obesity and (1) cesarean section (CS) and (2) fetal macrosomia. Methods: We searched MEDLINE-PubMed, Embase, Cochrane Library, Scopus, and Web of Science electronic databases up to 30 June 2019. We considered all maternal and birth cohort studies conducted in the six GCC countries (Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE)). We categorized cohort studies on the basis of the exposure(s) (anthropometric, environmental, medical, maternal/reproductive, perinatal, or socioeconomic) and outcome(s) (maternal or birth) being measured. Adjusted weighted effect estimates, in the form of relative risks, between maternal obesity and CS and fetal macrosomia were generated using a randomeffects model. Results: Of 3502 citations, 81 published cohort studies were included. One cohort study was in Bahrain, eight in Kuwait, seven in Qatar, six in Oman, 52 in Saudi Arabia, and seven in the UAE. Majority of the exposures studied were maternal/reproductive (65.2%) or medical (39.5%). Birth and maternal outcomes were reported in 82.7% and in 74.1% of the cohort studies, respectively. In Saudi Arabia, babies born to obese women were at a higher risk of macrosomia (adjusted relative risk (aRR), 1.15; 95% confidence interval (CI), 1.10-1.20; I 2 = 50%) or cesarean section (aRR, 1.21; 95% CI, 1.15-1.26; I 2 = 62.0%). Several cohort studies were only descriptive without reporting the magnitude of the effect estimate between the assessed exposures and outcomes. Conclusions: Cohort studies in the GCC have predominantly focused on reproductive and medical exposures. Obese pregnant women are at an increased risk of undergoing CS delivery or macrosomic births. Longer-term studies that explore a wider range of environmental and biological exposures and outcomes relevant to the GCC region are needed. Systematic review registration: PROSPERO CRD42017068910

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“…In relation to atopy and allergy, although less investigated than the effect of fetal programming in development of childhood asthma, increased 'stress' in-utero has been associated with elevated levels of cord blood IgE [19] and a fall off in fetal growth trajectory has been linked to later development of childhood eczema [20]. Asthma and atopy share a common pathophysiology and the common theme of a multifactorial origin of disease may offer some explanation for our study findings.…”

Section: Resultsmentioning

confidence: 66%

“…Interestingly, we noted a trend toward higher leptin and CRP levels in the elevated UAD PI group, which was not significant following adjusted analysis. Leptin and C-reactive protein are adipocytokines; a peptide hormone produced by the adipocytes [20].…”

Section: Resultsmentioning

confidence: 99%