The impact of fetal umbilical artery Doppler pulsatility index on childhood respiratory function and atopy: a prospective case-control study

Mone, Fionnuala; Thompson, Andrew; Stewart, Moira; Segurado, Ricardo; Curry, Jennifer; Dornan, James; McAuliffe, Fionnuala M.; Shields, Michael

doi:10.1080/14767058.2018.1499720

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…A historical study of n = 2097 fetuses evaluated if there was any effect on serial UAD PI testing at 28, 32 and 34 weeks' gestation on perinatal outcome [13]. The index prospective nested case-control compared two groups of children 11-12 years later, where at 28-weeks gestation they had an elevated (> 90th centile) or normal (< 10th centile) UAD PI [13,15,16]. Based on this cohort, results relating to the impact of UAD PI on cardiovascular, respiratory and neurocognitive outcome have been published previously [14,15,16].…”

Section: Methodsmentioning

confidence: 99%

“…The index prospective nested case-control compared two groups of children 11-12 years later, where at 28-weeks gestation they had an elevated (> 90th centile) or normal (< 10th centile) UAD PI [13,15,16]. Based on this cohort, results relating to the impact of UAD PI on cardiovascular, respiratory and neurocognitive outcome have been published previously [14,15,16]. Of the original cohort, n = 252 (12%) underwent neurocognitive assessment and following exclusion of growth-restricted (birthweight < 10th centile), preterm (< 37weeks), congenitally or genetically abnormal babies, cases where retrospective maternal information had been gathered regarding breastfeeding status and duration were selected and a secondary analysis of the aforementioned objectives was performed.…”

Section: Methodsmentioning

confidence: 99%

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The Impact of Breastfeeding on Neurocognitive Outcome at Twelve Years – Secondary Analysis of a Prospective Cohort Study

Reilly

McConnell

Thompson

et al. 2021

Preprint

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BackgroundThe objectives of this secondary analysis were to compare the; (i) cognitive and (ii) behavioural outcomes in children born congenitally normal, non-preterm, and non-growth restricted that were breastfed beyond one month of age with those that were not breastfed or breastfed for <1-month. MethodsAn original prospective cohort study conducted on n=2097 fetuses compared children with normal fetal UAD PI (Umbilical Artery Doppler Pulsatility Index) against those with an elevated UAD PI and assessed neurocognitive development at twelve years of age using British Ability Scale Version II (BAS II) and the Achenbach Behavioural Checklist Parent Rated Version (CBCL). This secondary analysis included children where maternal breastfeeding status was known (n=252). Childhood cognitive and behavioural scores were analysed and compared for the breastfed versus the non-breastfed group. Linear regression analysis was performed, controlling for confounders including gender, age at assessment, Townsend Score, and UAD PI. Results Excluding congenitally abnormal, preterm and growth restricted babies, n=206 were included. The mean age at follow-up was 12.2 years (±0.6 SD) for both groups with 43.5% (n=20) and 50.3% (n=81) of male gender in both groups respectively. When comparing those children who were breastfed against those who were not or for <1-month, the breastfed group score higher in spelling (p<0.001) and reading (p<0.001) assessments. As was also the case in verbal (p<0.001), reasoning (p<0.001) and spatial ability scores (p<0.001). In relation to behavioural assessments, there was no difference between groups. Conclusion Term babies who are breastfed for >1-month have more optimal scores in neurocognition when analysed at 12-years with no differences in parent observed behaviour compared to non-breastfed/breastfed for <1-month counterparts. These findings must be interpreted with caution due to the presence of confounders with further research into the biological and physiological mechanisms by which breastfeeding may optimise brain development.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The Impact of Breastfeeding on Neurocognitive Outcome at Twelve Years – Secondary Analysis of a Prospective Cohort Study

Reilly

McConnell

Thompson

et al. 2021

Preprint

Self Cite

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Fetal pulmonary artery Doppler blood flow velocity measures and early infant lung function. A prospective cohort study

Hilde

Guðmundsdóttir

Bains

et al. 2023

The Journal of Maternal-Fetal & Neonatal Medicine

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Double umbilical artery converging into a single umbilical artery: A case report

Yang,

Qiu

et al. 2024

Medicine

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Rationale: The normal structure and Doppler parameters of the umbilical cord are closely related to many diseases, including fetal infection, chromosomal abnormalities, hypoxia, and growth and development restrictions. We report a case of bilateral umbilical artery confluence resulting in the formation of a single umbilical artery in the free segment of the fetal umbilical cord, diagnosed at 24 weeks and 4 days gestation. The fetus was born prematurely after premature membrane rupture at 31 weeks and 3 days gestation. The Toxoplasma, Others, Rubellavirus, Cytomegalovirus, Herpesvirus test showed positive results for Toxoplasma gondii, rubella virus, and herpes simplex virus IgG antibodies. Patient concerns: A 36-year-old woman had vaginal discharge for > 1 hour at 31 weeks + 3 days gestation and came to our obstetrics department for treatment. Diagnosis: The pregnant woman sought treatment due to premature membrane rupture and vaginal discharge for > 1 hour. The vaginal discharge was caused by Escherichia coli. After cesarean section, the Toxoplasma, Others, Rubellavirus, Cytomegalovirus, Herpesvirus test revealed positive results for the following: T gondii, rubella virus, and herpes simplex virus IgG antibodies. The patient underwent 2 ultrasound examinations and was diagnosed with umbilical artery malformation (the free segment of the umbilical cord on the fetal side converged into a single umbilical artery), which may have been related to fetal infection. Interventions: The patient received anti-inflammatory and fetal lung maturation treatment for 2 days before undergoing a cesarean section. Outcomes: The mother and newborn received anti-inflammatory, symptomatic, and supportive treatment and were discharged after 1 week of improvement. After 1 month, 6 months, and 1 year of follow-up after birth, the growth and development of the infant (height and weight) were significantly lower than those of her peers, and her responses to sound and light were slightly delayed. Lessons: Umbilical artery malformation is extremely rare and may be related to intrauterine parasitic and viral infections. Ultrasound has the advantages of being noninvasive and cost-effective and can be used to dynamically observe umbilical artery structure. An abnormal change in umbilical artery structure found during ultrasound examination can indicate intrauterine infection risk, which provides clinical guidance for further examination of pregnant women, early diagnosis, timely targeted treatment, and fetal prognosis improvement.

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The impact of fetal umbilical artery Doppler pulsatility index on childhood respiratory function and atopy: a prospective case-control study

Cited by 4 publications

References 21 publications

The Impact of Breastfeeding on Neurocognitive Outcome at Twelve Years – Secondary Analysis of a Prospective Cohort Study

The Impact of Breastfeeding on Neurocognitive Outcome at Twelve Years – Secondary Analysis of a Prospective Cohort Study

Fetal pulmonary artery Doppler blood flow velocity measures and early infant lung function. A prospective cohort study

Double umbilical artery converging into a single umbilical artery: A case report

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