Fetal ionized magnesium levels parallel maternal levels during magnesium sulfate therapy for preeclampsia

Mason, Brian A.; Standley, Cynthia A.; Whitty, Janice E.; Cotton, David B.

doi:10.1016/s0002-9378(96)70277-6

Cited by 25 publications

(16 citation statements)

References 13 publications

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“…The serum Mg concentrations were higher in preterm and asphyxiated infants [31] . After MgSO 4 therapy, the total Mg concentrations were significantly increased and the fetal levels paralleled maternal levels [32] .…”

Section: Discussionmentioning

confidence: 90%

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Toyoshima¹,

Momma²,

Nakanishi³

2009

Neonatology

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Background: Magnesium sulfate (MgSO₄) is used therapeutically for eclampsia and tocolysis. Some reports have suggested a relationship between therapeutic MgSO₄ and patent ductus arteriosus (DA) in preterm infants. Objectives: To clarify patent DA induction by MgSO₄ in preterm infants, we studied the increase in serum Mg concentrations and fetal dilatation and postnatal delayed closure of the ductus, using transplacental MgSO₄ in rats. Methods: Fetal and neonatal ductus diameters were measured with a microscope and a micrometer after rapid whole-body freezing. In the postnatal study, 21-day pregnant dams were administered a subcutaneous injection of MgSO₄ 1–3 h before delivery, and the ductus was studied 0, 15, 30, 60 and 120 min after birth. In the fetal study, MgSO₄ (1 g/kg) and indomethacin (10 mg/kg) were simultaneously administered to 21-day dams and the fetal ductus was studied 1, 2 and 4 h later. Serum Mg concentration was measured in the dams and newborns. Results: Neonatal Mg concentrations increased from 3.8 to 4.7 and 5.8 mg/dl at 1 and 3 h after maternal administration of MgSO₄. Following MgSO₄ administration 3 h before birth, closure of the neonatal DA was delayed. The ductus diameter was 0.88 mm (0.80 mm in control) at 0 min, and 0.26 mm (0.08 mm in the control) at 60 min after birth. In the fetal study, MgSO₄ initially reversed and later attenuated the ductus-constricting effect of indomethacin. Conclusions: Hypermagnesemia induced by transplacental MgSO₄ attenuates the fetal ductus-constricting effects of indomethacin, and delays postnatal ductal closure in rats.

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Section: Discussionmentioning

confidence: 90%

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Toyoshima¹,

Momma²,

Nakanishi³

2009

Neonatology

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“…In women recieving magnesium sulfate (MgSO 4 ) therapy for preeclampsia, ionized Mg 2þ levels in cord blood parallel maternal Mg 2þ concentrations [11]. To date, our understanding of Mg 2þ transport at the molecular level remains limited, however recently identified Mg 2þ channels and transporters include TRPM6, TRPM7, MagT1 and SLC41A1 [12e15].…”

Section: Introductionmentioning

confidence: 99%

Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality

et al. 2015

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“…We have previously shown that fetal levels of magnesium increase in parallel with maternal levels upon administration of magnesium sulfate 18 . The electrolyte results in this study are consistent with our previous observations.…”

Section: Discussionmentioning

confidence: 94%

Maternal–fetal effects of magnesium sulfate on serum osmolality in pre-eclampsia

Heyden

Standley

2002

The Journal of Maternal-Fetal & Neonatal Medicine

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Fetal ionized magnesium levels parallel maternal levels during magnesium sulfate therapy for preeclampsia

Cited by 25 publications

References 13 publications

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Fetal Reversed Constrictive Effect of Indomethacin and Postnatal Delayed Closure of the Ductus Arteriosus following Administration of Transplacental Magnesium Sulfate in Rats

Maternal hypomagnesemia causes placental abnormalities and fetal and postnatal mortality

Maternal–fetal effects of magnesium sulfate on serum osmolality in pre-eclampsia

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