Fetal nutrition and cardiovascular disease in later life

Barker, Djp

doi:10.1093/oxfordjournals.bmb.a011609

Cited by 333 publications

(216 citation statements)

References 74 publications

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“…In the end, the Predictors of abdominal obesity J Laitinen et al importance of SGA tended to be associated with adult abdominal obesity only among subjects who were of normal weight at 14 y. Thus, our results do not provide much support for the programming hypothesis, which is used to describe the process whereby a stimulus or insult (eg undernutrition, hormones, antigens, drugs, etc) occurring during critical periods of development has life-long effects on the structure or function of organs, tissues or body systems (Barker, 1997). On the other hand, our findings do lend support to the alternative model which hypothesizes that the risk of chronic disease in adult life reflects cumulative differential lifetime exposure to damaging physical and social environments and forms of behavior (Blane, 1999;Holland et al, 2000).…”

Section: Discussioncontrasting

confidence: 69%

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Predictors of abdominal obesity among 31-y-old men and women born in Northern Finland in 1966

Laitinen¹,

et al. 2003

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Objective: To find predictors of abdominal obesity (defined by 490th percentile of waist/hip ratio (WHR)) and related factors among 31-y-old men and women. Design: Longitudinal study of the northern Finland birth cohort of 1966 with measurements obtained at birth, 14 and 31 y. Subjects: A total of 2841 men and 2930 women with data on WHR at 31 y. Results:The most important predictor of abdominal obesity among the 31-y-old men was a high body mass index (BMI), those with normal weight at 14 y who were obese at 31 y having an especially high risk of abdominal obesity at 31 y. Abdominal obesity was independently associated with current weight status, small size for gestational age, a high intake of alcohol at 31 y, physical inactivity at 31 y, unhealthy diet in the sense of infrequent consumption of fiber-rich foods and frequent consumption of sausages, and a low level of occupational training. Physical inactivity and minimal vocational training also tended to be associated with abdominal obesity among women. The analyses were controlled for maternal age and BMI, and also for hormonal contraception and parity among women. Conclusions: Some aspects of risk of adult abdominal obesity were evident during adolescence, and good advice is needed then, and in early adulthood, in order to reduce the risk of abdominal obesity in their thirties. Those who are small for gestational age are vulnerable to the development of abdominal obesity. Successful weight control from adolescence to adulthood, and healthy eating, alcohol drinking and exercise habits are important for avoiding abdominal accumulation of body fat.

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Section: Discussioncontrasting

confidence: 69%

“…The prevalence of abdominal obesity is increasing, and both waist circumference and WHR were found to have increased considerably among Finnish men and women over the 10-y period 1987-1997(Lahti-Koski et al, 2000a. Similar findings have also been observed among Swedish women (Lissner et al, 1998).…”

Section: Introductionsupporting

confidence: 70%

Predictors of abdominal obesity among 31-y-old men and women born in Northern Finland in 1966

Laitinen¹,

et al. 2003

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“…Such stresses have been related to elevated cortisol levels that in turn have been associated with central adiposity (Bjorntorp, 2001) and Brindley (Brindley & Rolland, 1989) set out plausible mechanistic pathways. Poorer maternal nutrition in the lower socioeconomic groups might also have compromised foetal nutrition and increased propensity to cardiovascular risk (Barker, 1997).…”

Section: Discussionmentioning

confidence: 99%

Childhood and adult dietary vitamin E intake and cardiovascular risk factors in mid-life in the 1946 British Birth Cohort

et al. 2003

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Objectives: To determine whether dietary vitamin E intake in childhood or mid-life was predictive of adult hypertension and high waist circumference, as two important risk factors for cardiovascular disease. Design: Longitudinal study of a social class stratified random sample of all the legitimate, singleton births in the week of 3-9 March 1946. Settings: England, Scotland and Wales. Subjects: The 2980 survey members who provided information on diet, health and sociodemographic information at two time points; age 4 y in 1950 (24-h dietary recall) and 43 y in 1989 (48-h dietary recall). Main outcome measures: Outcomes were adjusted odds ratios (ORs) for hypertension and high waist circumference at age 43 y by thirds of vitamin E intake, relative to the highest intake thirds at both ages. Results: The lowest consumers of vitamin E in both childhood and adulthood were more likely to be hypertensive (OR 1.8, 95% confidence interval (CI): 1.03-3.08) and have high waist circumference (OR 1.6, 95% CI: 1.02-2.43) than those consuming high levels at both ages. A low intake of vitamin E at just one time point was not associated with a statistically significant increased risk of hypertension or high waist circumference. Social class was also an independent and equally strong predictor of these coronary risk factors, indicating that the relation between social class and cardiovascular risks was not mediated solely by the current measures of diet and lifestyle. Conclusions: Unique data on vitamin E intake from foods in both childhood and adulthood have indicated that relatively low intake of vitamin E at both ages predicted hypertension and high waist circumference at age 43 y.

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“…2 Increasing evidence, however, suggests that environmental factors operating during early life may also in¯uence the development of obesity. 3,4 Longitudinal studies show that anthropometric measurements in infancy or early childhood tend to predict body size later in life. 5 ± 10 Moreover, excess body weight that accumulates during critical periods of development is more likely to persist.…”

Section: Introductionmentioning

confidence: 99%

Birth weight, climate at birth and the risk of obesity in adult life

2000

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OBJECTIVE: To determine whether obesity in adults is related to seasonal or climatic conditions around the time of birth. SUBJECTS: 1750 men and women born in Hertfordshire between 1920 and 1930. MEASUREMENTS: Height and weight measured in the home by trained ®eldworkers. RESULTS: Body mass index (BMI) rose with increasing birth weight in men and women. In men, BMI and the prevalence of obesity (BMI ! 30 kgam 2 ) varied as a function of month of birth and was greater among those born in January ± June than among those born in July ± December. The relationship between birth weight and adult obesity was also stronger in those born in the ®rst 6 months of the year or following cold winters than in those born in the last 6 months of the year or following mild winters. CONCLUSIONS: These ®ndings suggest that adult obesity is linked both to high birth weight and to early cold exposure. Consequently, exposures in early life may contribute to individual variation in susceptibility to obesity in adults.

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Fetal nutrition and cardiovascular disease in later life

Cited by 333 publications

References 74 publications

Predictors of abdominal obesity among 31-y-old men and women born in Northern Finland in 1966

Predictors of abdominal obesity among 31-y-old men and women born in Northern Finland in 1966

Childhood and adult dietary vitamin E intake and cardiovascular risk factors in mid-life in the 1946 British Birth Cohort

Birth weight, climate at birth and the risk of obesity in adult life

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